Perceptual implications of cochlear implant electrode-neuron interfaces

人工耳蜗电极-神经元界面的感知影响

• 批准号: 8607527
• 负责人: JULIE G Arenberg
• 金额: $ 38.63万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8607527
• 关键词: Accounting; Acoustic Nerve; Affect; Auditory; Characteristics; Clinic; Cochlea; Cochlear Implants; Complex; Computer Simulation; Confusion; Cueing for speech; Development; Discrimination; Distant; Electrodes; Elements; Environment; Esthesia; Exhibits; Goals; Growth; Hearing; High Resolution Computed Tomography; Image; Implant; Implanted Electrodes; Individual; Knowledge; Lead; Location; Loudness; Maps; Masks; Measures; Medial; Music; Neurons; Outcome; Pathology; Patients; Pattern; Perception; Performance; Physiologic pulse; Population; Positioning Attribute; Procedures; Psychophysics; Radial; Relative (related person); Research; Resolution; Source; Speech; Speech Discrimination; Speech Perception; Stimulus; Techniques; Testing; Time; X-Ray Computed Tomography; base; clinical practice; hearing impairment; improved; neural prosthesis; novel; novel strategies; programs; relating to nervous system; sound; spiral ganglion; success; theories; tool

DESCRIPTION (provided by applicant): Cochlear implants are highly successful neural prostheses that enhance or restore hearing to the severely hearing impaired. However, performance varies considerably among cochlear implant listeners, particularly in noisy environments and for spectrally complex stimuli like music. Pathology and imaging studies suggest that two sources of performance variability are the distribution of surviving spiral ganglion neurons and their distance from individual CI electrodes. This proposal uses psychophysical measures, computed tomography imaging, and computer modeling to assess how such factors affect the function of individual cochlear implant channels. That information will be applied to reprogram the implant processor in order to minimize the influence of poorly functioning channels. Three aims are proposed: 1) To determine the degree to which thresholds obtained using a spatially focused electrode configuration correlate with single-channel measures of spectral resolution, loudness growth, and electrode position within the cochlea; 2) To quantify the contributions of channels with high thresholds on the discrimination of speech stimuli; and 3) To determine if listener-specific mapping tailored to the estimated electrode-neuron interface from Aim 1 can improve perception on complex listening tasks. The results of these studies are expected to advance the field's understanding of how cochlear implant channel position and neural survival affect single-channel and speech perception. The findings have the potential to shift clinical practice by providing a guide for patient-specific channel mapping and ultimately lead to improved speech perception abilities in cochlear implant listeners.

描述（由申请人提供）：耳蜗植入物是非常成功的神经假体，可增强或恢复严重听力受损者的听力。然而，人工耳蜗的性能在不同的听众之间有很大的差异，特别是在嘈杂的环境中，以及对于像音乐这样的频谱复杂的刺激。病理学和成像研究表明，两个来源的性能变异性的生存螺旋神经节神经元的分布和它们的距离个别CI电极。该建议使用心理物理测量、计算机断层扫描成像和计算机建模来评估这些因素如何影响单个耳蜗植入通道的功能。该信息将用于重新编程植入物处理器，以最大限度地减少功能不良通道的影响。提出了三个目标：1）确定使用空间聚焦电极配置获得的阈值与耳蜗内的频谱分辨率、响度增长和电极位置的单通道测量的相关程度; 2）量化具有高阈值的通道对语音刺激的辨别的贡献;以及3）确定针对来自目标1的估计的电极-神经元界面定制的特定于神经元的映射是否可以改善对复杂听力任务的感知。这些研究的结果有望促进该领域对耳蜗植入通道位置和神经存活如何影响单通道和语音感知的理解。这些发现有可能通过为患者特定的通道映射提供指导来改变临床实践，并最终改善人工耳蜗植入者的语音感知能力。