Metalloproteinase Inhibitor For Pain and Morphine Tolerance Due To Thermal Injury

金属蛋白酶抑制剂，用于治疗热损伤引起的疼痛和吗啡耐受

• 批准号: 8639388
• 负责人: IRVING SUCHOLEIKI
• 金额: $ 26.2万
• 依托单位: AQUILUS PHARMACEUTICALS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2016-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639388
• 关键词: Address; Adverse effects; Anesthesia procedures; Animal Model; Behavioral; Biochemical; Biochemistry; Biological Availability; Biological Markers; Burn injury; Burning Pain; Cerebrospinal Fluid; Clinic; Dose; Drug Kinetics; Euphoria; Gelatin Zymography; Gelatinase A; Gelatinase B; Goals; Gold; Hospitalization; Hyperalgesia; Individual; Inflammatory; Injury; Interleukin-6; Matrix Metalloproteinase Inhibitor; Mechanics; Metalloproteases; Methods; Modeling; Morphine; National Institute of General Medical Sciences; Oral; Oral Administration; Pain; Pain management; Patients; Penetration; Perioperative; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Phase; Physiology; Plasma; Proteins; Rattus; Research; Rodent Model; Running; Small Business Innovation Research Grant; Spinal; Spinal Ganglia; Sprague-Dawley Rats; TNF gene; Testing; Tissues; Withdrawal; Work; addiction; allodynia; animal efficacy; animal pain; behavior change; cytokine; efficacy testing; follow-up; heat injury; inhibitor/antagonist; male; novel; painful neuropathy; public health relevance; response; scale up

DESCRIPTION (provided by applicant): Aquilus Pharmaceuticals, Inc. proposes to evaluate the effects of a proprietary matrix metalloproteinase (MMP) inhibitor, AQU-010, for blocking neuropathic pain and morphine tolerance in a thermal injury (TI) rat model. The goals for Phase I are to scale-up the synthesis of AQU-010, determine its oral pharmacokinetics (PK) and target tissue penetration and then determine its efficacy in the TI-rat model of mechanical and thermal allodynia. A follow-up biomarker and gelatin zymography analysis will be performed to determine if any behavior changes observed from the animal model correspond to changes in metalloproteinase and/or cytokine levels. The ultimate goal of the proposed work is to evaluate whether a matrix metalloproteinase inhibitor can be used to treat pain and/or morphine tolerance in patients suffering from burn injuries without producing euphoria and addiction.

描述（由申请人提供）：Aquilus Pharmaceuticals, Inc.提议评估专利基质金属蛋白酶（MMP）抑制剂aquo -010在热损伤（TI）大鼠模型中阻断神经性疼痛和吗啡耐受性的作用。第一阶段的目标是扩大aquo -010的合成规模，确定其口服药代动力学（PK）和靶组织穿透性，然后确定其在ti -大鼠机械和热异常性疼痛模型中的疗效。后续的生物标志物和明胶酶谱分析将进行，以确定从动物模型观察到的任何行为变化是否对应于金属蛋白酶和/或细胞因子水平的变化。这项工作的最终目的是评估基质金属蛋白酶抑制剂是否可以用于治疗烧伤患者的疼痛和/或吗啡耐受性，而不会产生欣快感和成瘾。