SYNTHESIS OF PEPTIDE AND NONPEPTIDE OPIOID ANALOGS

肽和非肽阿片类似物的合成

• 批准号: 2561057
• 负责人: IRVING SUCHOLEIKI
• 金额: $ 9.5万
• 依托单位: SOLID PHASE SCIENCES CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2561057
• 关键词: analog; biomedical automation; biomedical equipment development; chemical synthesis; drug design /synthesis /production; endogenous opioid; peptide library

DESCRIPTION: (Adapted from the applicant's abstract) Solid Phase Sciences Corporation (SPSC) proposes to produce a library of heptapeptide analogs and a library of alkylether substituted pyrolidineanalide analogs targeting the delta and k (kappa) opioid receptors. Both compound libraries will consist of 2-5 milligrams each of a total of 192 compounds. SPSC will accomplish this by utilizing it's novel high-loading paramagnetic support and a commercially available solvent delivery robot. Specifically, libraries will be made off of this high-loading paramagnetic support, utilizing sonication to assist in the mixing and running of the reactions. A constant magnetic field will be used to separate the support from the soluble components of the reaction mixture. A liquid handling robot will be used to add reagents and solvents and to remove waste solvents through suction. The goal of the Phase I effort will be to integrate sonication, magnetic separation and automated liquid handling into one automated system to produce a library composed of peptide and non- peptide compounds for opioid receptor screening.

描述：（改编自申请人摘要）固体相

项目成果

The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries.

使用功率超声与磁力分离相结合进行化合物库的固相合成。

• DOI: 10.1016/s0960-894x(99)00651-4
• 发表时间: 2000
• 期刊: Bioorganic & medicinal chemistry letters
• 影响因子: 2.7
• 作者: Perez,JM;Wilhelm,EJ;Sucholeiki,I
• 通讯作者: Sucholeiki,I