SOLID PHASE SYNTHESIS OF A COMBINATORIAL LIBRARY

组合文库的固相合成

• 批准号: 2010482
• 负责人: IRVING SUCHOLEIKI
• 金额: $ 9.96万
• 依托单位: SOLID PHASE SCIENCES CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1997-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2010482
• 关键词: acridines; analytical chemistry; chemical registry /resource; chemical synthesis; heterocyclic compounds; high performance liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; pyridine; reagent /indicator; robotics; solvents

Solid Phase Sciences Corporation (SPSC) proposes to produce a library of substituted acridine and pyridine based heterocycles. The library will consist of 5-10 milligrams each of a total of 384 compounds. SPSC will accomplish this by utilizing it's novel high-loading support and commercially available solvent delivery robot. Specifically, libraries will be made off of this high-loading support to separate the desired products from undesired starting material. A liquid handling robot will be used to add reagents and solvents. The goal of the Phase I effort will be to integrate the use of this high-loading support in solid phase synthesis with automated liquid handling into one automated system to produce a library composed of a series of acridine and pyridine based heterocyclic compounds for general screening.

固相科学公司（SPSC）提议建立一个图书馆