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SOLID PHASE SYNTHESIS OF A COMBINATORIAL LIBRARY

SOLID PHASE SYNTHESIS OF A COMBINATORIAL LIBRARY
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批准号：
2010482
负责人：
IRVING SUCHOLEIKI
金额：
$9.96万
依托单位：
SOLID PHASE SCIENCES CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 1997-10-31
来源：
https://reporter.nih.gov/project-details/2010482
关键词：
acridines analytical chemistry chemical registry /resource chemical synthesis heterocyclic compounds high performance liquid chromatography mass spectrometry nuclear magnetic resonance spectroscopy pyridine reagent /indicator robotics solvents

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中文摘要
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英文摘要
Solid Phase Sciences Corporation (SPSC) proposes to produce a library of substituted acridine and pyridine based heterocycles. The library will consist of 5-10 milligrams each of a total of 384 compounds. SPSC will accomplish this by utilizing it's novel high-loading support and commercially available solvent delivery robot. Specifically, libraries will be made off of this high-loading support to separate the desired products from undesired starting material. A liquid handling robot will be used to add reagents and solvents. The goal of the Phase I effort will be to integrate the use of this high-loading support in solid phase synthesis with automated liquid handling into one automated system to produce a library composed of a series of acridine and pyridine based heterocyclic compounds for general screening.
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