Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria

用于治疗耐药革兰氏阳性菌的新型恶二唑类药物

基本信息

  • 批准号:
    8692635
  • 负责人:
  • 金额:
    $ 99.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-07-15 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Staphylococcus aureus is responsible for a number of human diseases, including skin and soft tissue infections. Annually, 292,000 hospitalizations in the US are due to S. aureus infections, of which 126,000 are related to methicillin-resistant Staphylococcus aureus (MRSA), resulting in 19,000 deaths. Enterococci are the leading cause of nosocomial bacteremia, surgical wound infections, and urinary tract infections. Vancomycin-resistant enterococci (VRE) accounts for >25% of the enterococci hospital-acquired infections in the US. A novel structural lead, the oxadiazol class of antibiotics, has emerged from our work. The oxadiazol antibiotics show high in vitro potency against Gram-positive bacteria comparable to those of linezolid and superior to vancomycin (both considered gold standards) and show in vivo activity. In addition, the oxadiazols have activity against vancomycin- resistant MRSA and VRE, two organisms for which treatment options are extremely limited. The compounds in hand at this point are not highly water soluble and their pharmacokinetic properties are not optimized. This project proposes to optimize the initial lead discovery to come up with lead candidates with the correct mix of pharmacological activity, PK attributes, and safety profile, such that an oxadiazol drug candidate will be selected and advanced to preclinical development. We also propose a novel method for the identification and validation of the target(s) for the oxadiazol antibiotics in the proteome of S. aureus and put forth a whole genome method for investigation of the mechanism of resistance to this class of antibiotics. Infections caused by drug-resistant bacteria are an increasing unmet medical need. The drug of last resort, linezolid, is reserved for use in hard-to-treat methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE). New treatments are urgently needed to combat the emergence of resistance to any antibiotic after introduction of the antibiotic to the clinic. Our group has developed a new oxadiazol class of antibiotics that shows activity against vancomycin-resistant MRSA and VRE comparable to linezolid. Our goal is to develop a new class of antibiotics to treat drug-resistant bacterial infections.
描述(由申请人提供):金黄色葡萄球菌是导致许多人类疾病的原因,包括皮肤和软组织感染。美国每年有292,000例住院治疗是由于S。金黄色葡萄球菌感染,其中126,000例与耐甲氧西林金黄色葡萄球菌(MRSA)有关,导致19,000例死亡。肠球菌是医院内菌血症、手术伤口感染和尿路感染的主要原因。在美国,耐万古霉素肠球菌(VRE)占肠球菌医院获得性感染的25%以上。一个新的结构铅,恶二唑类抗生素,已经出现在我们的工作。恶二唑类抗生素对革兰氏阳性菌的体外效价高,与利奈唑胺相当,上级万古霉素(均被视为金标准),并显示出体内活性。此外,恶二唑类对万古霉素抗性MRSA和VRE具有活性,这两种生物体的治疗选择极其有限。此时,手头的化合物不是高度水溶性的,并且它们的药代动力学性质没有优化。该项目旨在优化最初的先导药物发现,以获得具有正确药理活性、PK属性和安全性特征的先导候选药物,从而选择恶二唑候选药物并推进临床前开发。我们还提出了一种新的方法来鉴定和验证S蛋白质组中恶二唑类抗生素的靶点。并提出了一种研究该类抗生素耐药机制的全基因组方法。 由耐药细菌引起的感染是一个日益增长的未满足的医疗需求。利奈唑胺是最后的药物,用于难以治疗的耐甲氧西林的S。金黄色葡萄球菌(MRSA)和万古霉素耐药肠球菌(VRE)。迫切需要新的治疗方法来对抗在将抗生素引入临床后出现的对任何抗生素的耐药性。我们的团队已经开发出一种新的恶二唑类抗生素,其对万古霉素耐药MRSA和VRE的活性与利奈唑胺相当。我们的目标是开发一类新的抗生素来治疗耐药细菌感染。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
天然产物艾斯拉霉素及其三种异构体缺乏抗菌活性。
  • DOI:
    10.1021/acs.jnatprod.6b00057
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Wang,Huan;Hesek,Dusan;Lee,Mijoon;Lastochkin,Elena;Oliver,AllenG;Chang,Mayland;Mobashery,Shahriar
  • 通讯作者:
    Mobashery,Shahriar
Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.
  • DOI:
    10.1016/j.bmcl.2015.12.041
  • 发表时间:
    2016-02-01
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Leemans E;Mahasenan KV;Kumarasiri M;Spink E;Ding D;O'Daniel PI;Boudreau MA;Lastochkin E;Testero SA;Yamaguchi T;Lee M;Hesek D;Fisher JF;Chang M;Mobashery S
  • 通讯作者:
    Mobashery S
Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.
  • DOI:
    10.1016/j.bmcl.2015.06.044
  • 发表时间:
    2015-11-01
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Ding D;Boudreau MA;Leemans E;Spink E;Yamaguchi T;Testero SA;O'Daniel PI;Lastochkin E;Chang M;Mobashery S
  • 通讯作者:
    Mobashery S
Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus.
mmpL 和细胞壁应激刺激的突变导致耐甲氧西林金黄色葡萄球菌对恶二唑类抗生素产生耐药性。
  • DOI:
    10.1128/aac.03501-14
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Xiao,Qiaobin;Vakulenko,Sergei;Chang,Mayland;Mobashery,Shahriar
  • 通讯作者:
    Mobashery,Shahriar
Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.
发现具有革兰氏阳性抗菌活性的青霉素结合蛋白的新型非β-内酰胺抑制剂。
  • DOI:
    10.1021/ja500053x
  • 发表时间:
    2014-03-05
  • 期刊:
  • 影响因子:
    15
  • 作者:
    O'Daniel PI;Peng Z;Pi H;Testero SA;Ding D;Spink E;Leemans E;Boudreau MA;Yamaguchi T;Schroeder VA;Wolter WR;Llarrull LI;Song W;Lastochkin E;Kumarasiri M;Antunes NT;Espahbodi M;Lichtenwalter K;Suckow MA;Vakulenko S;Mobashery S;Chang M
  • 通讯作者:
    Chang M
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Mayland F Chang其他文献

Mayland F Chang的其他文献

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{{ truncateString('Mayland F Chang', 18)}}的其他基金

The quinazolinone class of antibacterial agents
喹唑啉酮类抗菌剂
  • 批准号:
    9222697
  • 财政年份:
    2015
  • 资助金额:
    $ 99.05万
  • 项目类别:
The quinazolinone class of antibacterial agents
喹唑啉酮类抗菌剂
  • 批准号:
    8856982
  • 财政年份:
    2015
  • 资助金额:
    $ 99.05万
  • 项目类别:
The quinazolinone class of antibacterial agents
喹唑啉酮类抗菌剂
  • 批准号:
    9037579
  • 财政年份:
    2015
  • 资助金额:
    $ 99.05万
  • 项目类别:
Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
用于治疗耐药革兰氏阳性菌的新型恶二唑类药物
  • 批准号:
    8485537
  • 财政年份:
    2010
  • 资助金额:
    $ 99.05万
  • 项目类别:
Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
用于治疗耐药革兰氏阳性菌的新型恶二唑类药物
  • 批准号:
    8288684
  • 财政年份:
    2010
  • 资助金额:
    $ 99.05万
  • 项目类别:
Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
用于治疗耐药革兰氏阳性菌的新型恶二唑类药物
  • 批准号:
    8105043
  • 财政年份:
    2010
  • 资助金额:
    $ 99.05万
  • 项目类别:
Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
用于治疗耐药革兰氏阳性菌的新型恶二唑类药物
  • 批准号:
    7988818
  • 财政年份:
    2010
  • 资助金额:
    $ 99.05万
  • 项目类别:
Chemistry-Biochemistry-Biology Training Program at Notre Dame
圣母大学化学-生物化学-生物学培训项目
  • 批准号:
    8689089
  • 财政年份:
    2007
  • 资助金额:
    $ 99.05万
  • 项目类别:
Intervention of Disease by Selective Gelatinase Inhibitors
选择性明胶酶抑制剂对疾病的干预
  • 批准号:
    7900621
  • 财政年份:
    2007
  • 资助金额:
    $ 99.05万
  • 项目类别:
Intervention of Disease by Selective Gelatinase Inhibitors
选择性明胶酶抑制剂对疾病的干预
  • 批准号:
    7665470
  • 财政年份:
    2007
  • 资助金额:
    $ 99.05万
  • 项目类别:

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New technologies for targeted delivery of anti-bacterial agents
抗菌药物靶向递送新技术
  • 批准号:
    1654774
  • 财政年份:
    2015
  • 资助金额:
    $ 99.05万
  • 项目类别:
    Studentship
Targeting bacterial phosphatases for novel anti-bacterial agents.
针对细菌磷酸酶的新型抗菌剂。
  • 批准号:
    8416313
  • 财政年份:
    2012
  • 资助金额:
    $ 99.05万
  • 项目类别:
Targeting bacterial phosphatases for novel anti-bacterial agents.
针对细菌磷酸酶的新型抗菌剂。
  • 批准号:
    8298885
  • 财政年份:
    2012
  • 资助金额:
    $ 99.05万
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