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Understanding the context-dependent roles of mutations in lymphoma.

Understanding the context-dependent roles of mutations in lymphoma.
了解突变在淋巴瘤中的背景依赖性作用。
批准号：
8761919
负责人：
Sandeep Dave
金额：
$28.32万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-02-18 至 2019-08-31
来源：
https://reporter.nih.gov/project-details/8761919
关键词：
AccountingB-LymphocytesBiological ProcessBiologyClinicalClustered Regularly Interspaced Short Palindromic RepeatsDataData QualityDiseaseEmployee StrikesEventExclusionGene ExpressionGene Expression ProfileGene Expression ProfilingGene MutationGenerationsGenesGeneticGenetic HeterogeneityGenomicsGoalsHeterogeneityHigh-Throughput Nucleotide SequencingHumanIn VitroIndividualInvestmentsKnockout MiceKnowledgeLinkLymphomaMalignant NeoplasmsMethodsModelingMolecular ProfilingMutateMutationOncogenicOutcomePathway interactionsPatientsPatternPhenotypeRNA SequencesResearchRoleStructure of germinal center of lymph nodeSubgroupSystemTumor BiologyWorkbaseclinical phenotypeexome sequencingimprovedin vivolarge cell Diffuse non-Hodgkin&aposs lymphomanext generation sequencingnovelnovel strategiesnovel therapeuticspublic health relevancescreeningtherapeutic targettumor

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DESCRIPTION (provided by applicant): Recent work from our group and others has provided a wealth of information regarding the genetic makeup of lymphomas and other tumors. However, it is unclear how these genetic mutations actually cause the disease and the degree to which they are associated with known biological processes and outcome. In this proposal, we seek to study how different genetic mutations are associated with known lymphoma phenotypes and the context-dependent roles of genetic mutations.
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