The genetics of hepatosplenic T cell lymphoma

肝脾T细胞淋巴瘤的遗传学

• 批准号: 8880794
• 负责人: Sandeep Dave
• 金额: $ 21.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8880794
• 关键词: A Mouse; Age of Onset; Behavior; Burkitt Lymphoma; Clinical; DNA Sequence Alteration; Data; Disease; Event; Formalin; Genetic; Goals; Hematologic Neoplasms; Hereditary Disease; Human; Immunoblastic Lymphadenopathy; Incidence; Institution; Knock-out; Knockout Mice; Lesion; Liver; Lymphoma; Methods; Molecular; Mus; Mutation; Non-Hodgkin' s Lymphoma; Normal tissue morphology; Paraffin Embedding; Pathogenesis; Patients; Peripheral; RNA Sequences; Recurrence; Research; Role; Spleen; T-Cell Lymphoma; T-Lymphocyte; Tissues; Work; base; chemotherapy; exome sequencing; genetic profiling; large cell Diffuse non-Hodgkin' s lymphoma; mouse model; new therapeutic target; next generation sequencing; novel therapeutics; public health relevance; targeted treatment; therapeutic target; transcriptome sequencing; tumor

 DESCRIPTION (provided by applicant): Hepatosplenic T cell lymphoma is a rare, but lethal disease. The median age of onset is 35 and the expected median survival is less than two years. Very little is known about the genetic alterations underlying this disease. In this proposal we seek to define the genetics of the disease through exome and RNA sequencing of both primary human tumors and from the only known mouse model of the disease.

 描述（由申请人提供）：肝脾T细胞淋巴瘤是一种罕见但致命的疾病。发病的中位年龄为35岁，预期的中位生存期不到两年。关于这种疾病背后的遗传改变知之甚少。在这项提案中，我们试图通过原发性人类肿瘤和唯一已知的小鼠模型的外显子组和RNA测序来定义疾病的遗传学。