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The genetics of hepatosplenic T cell lymphoma

The genetics of hepatosplenic T cell lymphoma
肝脾T细胞淋巴瘤的遗传学
批准号：
8880794
负责人：
Sandeep Dave
金额：
$21.71万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-04-01 至 2017-03-31
来源：
https://reporter.nih.gov/project-details/8880794
关键词：
A MouseAge of OnsetBehaviorBurkitt LymphomaClinicalDNA Sequence AlterationDataDiseaseEventFormalinGeneticGoalsHematologic NeoplasmsHereditary DiseaseHumanImmunoblastic LymphadenopathyIncidenceInstitutionKnock-outKnockout MiceLesionLiverLymphomaMethodsMolecularMusMutationNon-Hodgkin&aposs LymphomaNormal tissue morphologyParaffin EmbeddingPathogenesisPatientsPeripheralRNA SequencesRecurrenceResearchRoleSpleenT-Cell LymphomaT-LymphocyteTissuesWorkbasechemotherapyexome sequencinggenetic profilinglarge cell Diffuse non-Hodgkin&aposs lymphomamouse modelnew therapeutic targetnext generation sequencingnovel therapeuticspublic health relevancetargeted treatmenttherapeutic targettranscriptome sequencingtumor

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英文摘要
 DESCRIPTION (provided by applicant): Hepatosplenic T cell lymphoma is a rare, but lethal disease. The median age of onset is 35 and the expected median survival is less than two years. Very little is known about the genetic alterations underlying this disease. In this proposal we seek to define the genetics of the disease through exome and RNA sequencing of both primary human tumors and from the only known mouse model of the disease.
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