FASEB SRC on G protein-coupled receptor kinases: From molecules to diseases.

FASEB SRC 关于 G 蛋白偶联受体激酶：从分子到疾病。

基本信息

批准号：
8719359
负责人：
Eugenia V Gurevich
金额：
$ 2.5万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8719359
关键词：
Affect American Animals Arrestins Attention Biochemical Biological Models Biology Catecholamines Cells Collaborations Communication Communities Data Development Disease Drug Addiction Drug Targeting Drug abuse Drug usage Endocrine Erinaceidae Face G Protein-Coupled Receptor Signaling G protein coupled receptor kinase G-Protein-Coupled Receptors GRK Growth Factor Receptors Heart Heterotrimeric GTP-Binding Proteins Histocompatibility Testing Hormones Human In Vitro Individual International Knowledge Laboratories Learning Life Long-Term Effects Mediating Methods Molecular Molecular Biology Neurosciences Neurotransmitters Organism Outcome Participant Pathway interactions Pharmaceutical Preparations Pharmacology Phosphorylation Phosphotransferases Physiological Physiological Processes Postdoctoral Fellow Process Property Protein Isoforms Proteins Publications Regulation Request for Applications Request for Proposals Research Research Personnel Resource Sharing Resources Role Science Scientist Second Messenger Systems Seminal Series Signal Pathway Signal Transduction Signaling Protein Societies Specificity Structure Students Substance abuse problem System cell type desensitization experience genetic regulatory protein human disease meetings novel novel therapeutic intervention posters programs public health relevance receptor research study response second messenger small molecule symposium therapeutic target

项目摘要

DESCRIPTION (provided by applicant): The application requests partial support for the "G protein-coupled receptor kinases: From molecules to diseases" meeting organized as a part of the Science Research Conference (SRC) program sponsored by Federation by American Societies for Experimental Biology (FASEB). G protein-coupled receptor kinases (GRK) are the key regulatory proteins determining the rate and extent of desensitization of G protein-coupled receptors (GPCR) and, consequently, impacting the intensity and duration of the GPCR signaling. They are also critical regulators of signaling pathways mediated through arrestin proteins as well as traditional heterotrimeric G proteins. Considering that GPCR dysregulation is a main contributor to many diseases and that GPCRs are the prime targets of clinically used drugs, GRKs emerge as important regulators of multiple physiological processes and potentially critical, although currently underappreciated, drug targets. The filed of GRK research has undergone considerable expansion in the past 10 years fueled by seminal discoveries of phosphorylation-independent functions of GRKs, GRK action at non- GPCR targets, and GRK roles in normal physiological and disease processes as well as drug effects. However, GRK research faces considerable challenges due to the unusual biochemical properties of GRKs as kinases and the lack of small molecules selectively targeting GRK isoforms. So far, researchers studying GRK-dependent regulation of cell signaling have communicated via publications and presented their research at large multi-focused meetings such as Annual Meeting of Society for Neuroscience, Endocrine Society meeting, Heart Association meeting, etc. However, GRK-specific subjects such as receptor specificity of GRK isoforms, mechanisms of GRK activation by GPCRs, regulation of GRK expression, degradation, subcellular targeting, as well as specific functions of GRKs in human disorders and therapies, have not been not adequately represented at such meetings. This meeting will bring together researches studying GRK biology from molecular as well as physiological and disease standpoint. All speakers will be encouraged to present unpublished cutting edge data in their talk to stimulate discussion. The meeting will also allow for communication between world leaders in GRK research with new investigators. The meeting format includes plenary sessions with presentations from established and young investigators, poster sessions, and "Meet the expert" session. Facilities and the meeting arrangement will provide ample opportunities for informal discussions among participants of all levels of experience coming from diverse backgrounds. In summary, the meeting will offer a unique forum for the open exchange of ideas that will benefit the scientific community and provide a strong momentum to move the field forward.

描述（申请人提供）：申请要求对“ G蛋白偶联受体激酶：从分子到疾病”的“ G蛋白偶联受体激酶”，这是科学研究会议（SRC）计划（SRC）计划的一部分，由美国社会联合会为实验生物学（FaseB）发起。 G蛋白偶联受体激酶（GRK）是确定G蛋白偶联受体（GPCR）脱敏的速率和程度的关键调节蛋白，因此影响GPCR信号的强度和持续时间。它们也是通过阻止蛋白以及传统异三聚体G蛋白介导的信号通路的关键调节剂。考虑到GPCR失调是导致许多疾病的主要因素，并且GPCR是临床使用药物的主要靶标，因此GRK是多种生理过程的重要调节剂，并且可能至关重要，尽管目前不足为药物靶标。在过去的10年中，GRK研究的提交经历了大量扩展，这是由于GRK的磷酸化独立功能，非GPCR目标的GRK作用以及GRK在正常生理和疾病过程中的作用以及药物效应的作用。然而，由于GRK的异常生化特性，GRK研究面临着巨大的挑战，并且缺乏小分子选择性地靶向GRK同工型。 So far, researchers studying GRK-dependent regulation of cell signaling have communicated via publications and presented their research at large multi-focused meetings such as Annual Meeting of Society for Neuroscience, Endocrine Society meeting, Heart Association meeting, etc. However, GRK-specific subjects such as receptor specificity of GRK isoforms, mechanisms of GRK activation by GPCRs, regulation of GRK expression, degradation, subcellular targeting, as在此类会议上，GRK在人类疾病和疗法中的特定功能尚未得到充分代表。这次会议将从分子以及生理和疾病的角度进行研究，研究GRK生物学。鼓励所有演讲者在他们的谈话中介绍未出版的前沿数据以刺激讨论。这次会议还将允许世界领导人与新研究人员之间的GRK研究中的沟通。会议格式包括全体会议，包括既定和年轻调查员，海报会议的演讲以及“会见专家”会议。设施和会议安排将为参与者之间的非正式讨论提供充足的机会，以了解来自不同背景的各种经验。总而言之，会议将为开放的思想交流提供一个独特的论坛，这些论坛将使科学界受益，并提供强大的动力来推动该领域的前进。