Molecular Analysis, Modeling and Correction of Skin Diseases Core Center

皮肤病分子分析、建模与矫正核心中心

• 批准号: 8740874
• 负责人: DAVID A. NORRIS
• 金额: $ 62.02万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8740874
• 关键词: Address; Advisory Committees; Area; Autoimmune Process; Basic Science; Biochemistry; Biology; Biomedical Engineering; Cancer Grant Supplements (P30); Chairperson; Clinical; Clinical Research; Clinical Trials; Collaborations; Colorado; Cutaneous; Dermatology; Development; Developmental Biology; Disease; Environment; Epithelial; Faculty; Flow Cytometry; Foundations; Funding; Gene Targeting; Genetic; Genetic Programming; Genetic Skin Diseases; Genomics; Goals; Grant; Head; Human; Human Resources; Immune; Immunity; Inflammation; Inflammatory; International; Investments; Laboratories; Leadership; Medical; Medical Genetics; Medical center; Mentorship; Metabolic; Microbiology; Modeling; Molecular; Molecular Analysis; Molecular Genetics; Molecular and Cellular Biology; Morphology; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Immunity; Paper; Pharmacology; Phenotype; Process; Publishing; Regenerative Medicine; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Role; Science; Scientist; Series; Services; Site; Skin; Speed; Stem cells; Structure; Suggestion; Techniques; Time; Transgenic Organisms; Translational Research; Universities; adaptive immunity; animal model development; appendage; base; carcinogenesis; experience; genetic analysis; innovation; interest; keratinocyte differentiation; melanocyte; member; new technology; programs; public health relevance; research facility; skin disorder; stem cell biology; success; tissue repair; virology

DESCRIPTION (provided by applicant): This is competing renewal of the SDRC "Molecular Analysis, Modeling and Correction of Skin Diseases Core Center". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base; The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program "A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.

描述（由申请人提供）：这是SDRC“分子分析，模型和校正皮肤疾病核心中心”的竞争。这是科罗拉多大学安索兹大学医疗校园（UCAMC）的一项广泛计划，其中有56名成员在皮肤病学系内。它的目标是通过分子技术纠正人类皮肤疾病。该中心的前4年取得了非常成功的成功：协作项目或P＆F项目中的SDRC调查人员为机构研究基础增加了20,371,611美元的新研究资金；在最初的4年中，P＆F计划本身已显示出约35倍的投资回报。 SDRC内部的合作产生了71篇已发表的论文，这些论文得到了研究核心的大力支持。丰富计划和合作管理为皮肤病相关研究创建了强大的研究人员的协作网络。 在接下来的5年期间，我们将为大卫·诺里斯（David Norris），丹尼斯·鲁普（Dennis Roop）和理查德·斯普里茨（Richard Spritz）的领导团队添加小王王。我们将保留5个核心（行政核心，分子遗传分析核心，生物工程核心，形态和表型核心以及流式细胞仪核心），但是根据前4年的资助经验以及咨询委员会的建议，提供的服务将改变和增强。创建：全球皮肤疾病将大大扩展丰富计划，以促进国际研究协作，并加快新科学在激动人心的转化研究项目中的应用，以“一项新技术计划”计划“新技术计划”，在UCAMC-SDRC和全球联盟中促进研究中的研究。在全球全球的研究中，通过此SDRC开发的研究将通过新的研究成员来促进新的研究，这将是新的，这将是新的SDRC，这将是新的SDRC，这将是新的SDRC，将会促进新的SDRC，这将是新技术的研究。 AMC上SDRC成员实验室和临床设施的设施非常接近。