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Investigating Molecular Reorganisation During Permeation Gating in K+ Channels

Investigating Molecular Reorganisation During Permeation Gating in K+ Channels
研究 K 通道渗透门控过程中的分子重组
批准号：
nhmrc : 1006624
负责人：
Dr Jacqueline Gulbis
金额：
$53.82万
依托单位：
The Walter and Eliza Hall Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2011
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2011-01-01 至 2013-12-31
来源：
https://researchdata.edu.au/investigating-molecular-reorganisation-k-channels/109201
关键词：
InvestigatingMolecularReorganisationDuringPermeation

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英文摘要
The capacity to control the passage of molecules across membranes underpins cellular function. Potassium channels are membrane-embedded pores essential in transmission of electrical signals. This proposal focuses on the means by which the flow of K+ charge through these channels is controlled and regulated. We are analysing the process by applying a combination of X-ray crystallography and electrophysiological methods to K+ channels in which specific functions have been perturbed by mutation.
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