Investigating Molecular Reorganisation During Permeation Gating in K+ Channels

控制分子穿过细胞膜的能力是细胞功能的基础。钾离子通道是在电信号传输中必不可少的膜包埋孔。本建议的重点是通过这些渠道的K+电荷的流动是控制和调节的手段。我们正在分析的过程中，应用X射线晶体学和电生理学方法相结合的K+通道，其中特定的功能已被突变扰动。

The capacity to control the passage of molecules across membranes underpins cellular function. Potassium channels are membrane-embedded pores essential in transmission of electrical signals. This proposal focuses on the means by which the flow of K+ charge through these channels is controlled and regulated. We are analysing the process by applying a combination of X-ray crystallography and electrophysiological methods to K+ channels in which specific functions have been perturbed by mutation.