Investigating the Interaction of Precursor Inner Membrane Proteins with Translocase Components
Investigating the Interaction of Precursor Inner Membrane Proteins with Translocase Components
批准号:
nhmrc : 1006628
负责人:
Dr Jacqueline Gulbis
金额:
$39.03万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Proteins are synthesised on ribosomes located in the cellular plasm, and then moved to their site of action by specialised transport systems. Import of proteins to the mitochondria involves translocase pores, which come equipped with receptors and chaperones. We are investigating the targeting and transfer of newly synthesised proteins of the MCF carrier family from the ribosomal machinery to the inner mitochondrial membrane, focusing on interaction with chaperones in the intermembrane space.
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