Tools for Managing and Disseminating Cardiac Electrophysiology Data

管理和传播心脏电生理学数据的工具

• 批准号: 8676904
• 负责人: RAIMOND Lester WINSLOW
• 金额: $ 44.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-05 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676904
• 关键词: Accreditation; Address; American; Animal Disease Models; Animal Model; Archives; Arrhythmia; Beds; Behavior; Biological; Biological Markers; Biomedical Engineering; Biomedical Research; Cardiac; Cardiac Function Study; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Cells; Cessation of life; Clinical Data; Communities; Community Outreach; Complex; Computer Simulation; Data; Data Analyses; Data Set; Databases; Disease; Documentation; Electrodes; Electrophysiology (science); Epigenetic Process; Evaluation; Extensible Markup Language; Genetic; Goals; Health; Heart; Heart Diseases; Human; Image; Individual Differences; International; Journals; Lead; Life; Link; Malignant Neoplasms; Measurement; Metadata; Methods; Mission; Modeling; Molecular; Molecular Genetics; Muscle Cells; National Heart, Lung, and Blood Institute; Ontology; Ownership; Peer Review; Phenotype; Physiological; Physiology; Play; Preparation; Procedures; Proteomics; Protocols documentation; Publications; Publishing; Research; Research Infrastructure; Research Personnel; Resource Development; Resources; Retrieval; Risk; Role; Sampling; Security; Series; Services; Societies; Software Tools; Staging; System; Systems Biology; Techniques; Testing; Therapeutic; Time; Tissues; Western World; Work; base; data exchange; data mining; data modeling; data sharing; database of Genotypes and Phenotypes; design; fluorescence imaging; heart function; human data; human tissue; insight; instrument; instrumentation; mortality; peer; repository; research study; sudden cardiac death; tool; tool development; virtual; web interface

DESCRIPTION (provided by applicant): Electrophysiology is a branch of physiology that pertains to the electrical activity of cells and tissues, and the electrical recording techniques that enable measurement of this activity. Electrophysiological data are typically collected using single-electrodes, electrode arrays, and fluorescent imaging systems. They are the most common type of data collected in basic studies of cardiac cells and tissues, as well as many other types of excitable cells. The reason for this is that these data can be used to relate molecular function to the electrical activity of cardiac muscle cells in health and disease. Establishing this relationship is a critically important task, since sudden cardiac death (SCD) from electrical arrhythmia is now the leading cause of mortality in the Western world, exceeding cancer in deaths per year. The number of cardiac electrophysiological (CEP) studies supported by the NHLBI, and the quantity and variety of data collected in these studies of heart function, vastly exceeds that for genetic, transcriptional or proteomic studies. While there are resources (e.g., dbGaP, dbSNP, GEO, ArrayExpress, World-2DPAGE Repository, etc) for the documentation and dissemination of these latter data types, no infrastructure exists for managing and sharing celular, tissue, and whole-heart electrophysiological data. The lack of this infrastructure means that these data are being "lost" in the sense that they exist only in the labs of those who collect it. They are seldom, if ever, disseminated by any means other than publication in peer-reviewed journals. Published data sets are limited to a few ideal examples presented in a way (images) that does not support re-use and further quantitative analysis. To address this problem, our goal is to create software tools for annotating, storing, sharing, and querying CEP data, including both primary data from measurement instrumentation and metadata regarding experimental protocols and results of data analyses. The Cardiovascular Research Grid Project will host a national repository for these experimental data and metadata. The creation of this national repository will, for the first time, make it possible for researchers to organize, archive, and search their own data and share it with others. It will enable re-use of the data so that other groups can mine the data for new results, use the data to design new experiments, and to formulate computational models of cell, tissue and heart function in health and disease. The ability to annotate data according to species, disease, and animal models of disease (including de-identified data from human tissue), as well as other ways, will support deep analysis of the electrophysiological basis of heart disease. Each of these capabilities will help provide fundamentally important insights into the mechanisms of cardiac arrhythmias, and possible therapeutic approaches that can help reduce risk of SCD.

描述（由申请人提供）：电生理学是与细胞和组织的电活动有关的生理学分支，以及能够测量该活性的电气记录技术。通常使用单电极，电极阵列和荧光成像系统收集电生理数据。它们是心脏细胞和组织以及许多其他类型的激发细胞中收集的最常见数据类型。原因是这些数据可用于将分子功能与心脏肌肉细胞在健康和疾病中的电活动相关联。建立这种关系是一项至关重要的任务，因为电气心律不齐的突然心脏死亡（SCD）现在是西方世界死亡率的主要原因，每年死亡的癌症超过了癌症。 NHLBI支持的心脏电生理学（CEP）研究的数量以及这些心脏功能研究中收集的数据的数量和品种，大大超过了遗传，转录或蛋白质组学研究的数量。尽管有资源（例如DBGAP，DBSNP，GEO，ArrayExpress，World-2Dpage存储库等）用于文档和后来数据类型的文档和传播，但不存在用于管理和共享CELULAR，组织和全心脏病生理学数据的基础架构。缺乏这种基础架构意味着这些数据仅在收集它的人的实验室中存在“丢失”。除了同行评审期刊中的出版物以外，它们很少会被任何其他方式传播。已发布的数据集仅限于以不支持重复使用和进一步定量分析的方式（图像）提供的一些理想示例。为了解决这个问题，我们的目标是创建用于注释，存储，共享和查询CEP数据的软件工具，包括有关实验协议和数据分析结果的测量仪器和元数据的主要数据。心血管研究网格项目将拥有这些实验数据和元数据的国家存储库。这个国家存储库的创建将首次使研究人员可以组织，归档和搜索自己的数据并与他人共享。它将重新使用数据，以便其他组可以为新结果挖掘数据，使用数据设计新实验，并制定健康和疾病中细胞，组织和心脏功能的计算模型。根据疾病的物种，疾病和动物模型（包括从人体组织的鉴定数据）以及其他方式来注释数据的能力，将支持对心脏病电生理基础的深入分析。这些能力中的每一个都将有助于提供对心律不齐机制的根本重要见解，以及可能有助于降低SCD风险的可能的治疗方法。