Short Course on Integrative Modeling of the Cardiac Myocyte

心肌细胞综合建模短期课程

基本信息

批准号：
7391159
负责人：
RAIMOND Lester WINSLOW
金额：
$ 20.97万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7391159
关键词：
Action Potentials Address Adrenergic Agents Affect Agreement Air Algorithms Alternative Splicing Ambulatory Care Archives Area Arteries Attention Back Be++ element Behavior Beryllium Binding Biological Biological Models Biology Biomedical Engineering Bite Buffers Ca(2+)-Transporting ATPase Canis familiaris Carboxylic Acids Cardiac Cardiac Myocytes Cardiovascular Physiology Cardiovascular system Cavia Cell model Cells Citric Acid Cycle Class Communication Communities Computer Simulation Computer software Computers Condition Copyright Coupled Coupling Cyclic AMP-Dependent Protein Kinases Data Databases Depth Derivation procedure Development Diffusion Dimensions Documentation Drug Formulations Educational Curriculum Educational process of instructing Effectiveness Electron Transport Electronic library Electronics Elements Engineering Enrollment Environment Equation Equilibrium Evaluation Exercise Exposure to Extensible Markup Language Extracellular Fluid Faculty Feedback Fluorescence Resonance Energy Transfer Foundations Future G-Protein-Coupled Receptors Gene Proteins Generations Genetic Goals Graph Hand Heart Heart Atrium Heart failure Histology Hodgkin Disease Hour Human Individual Instruction Internet Investigation Ion Channel Ions Kidney Knowledge Laboratories Latex Learning Libraries Licensing Link Literature Location M cell Markov Chains Mathematics Medical Education Membrane Membrane Potentials Membrane Transport Proteins Metabolic Control Methodology Methods Mitochondria Modeling Modification Molecular Models Molecular Target Muscle Cells Mutation Myocardium Names Neurons Neurosciences Noma Numbers Online Systems Operative Surgical Procedures Oral Paper Participant Pathway interactions Performance Phase Phenotype Physiology Postdoctoral Fellow Potassium Channel Preparation Principal Investigator Problem Solving Procedures Process Production Program Reviews Property Proteins Protocols documentation Protons PubMed Publications Published Comment Publishing Pump Purpose Quantitative Evaluations Question Text Range Rate Reaction Reading Recombinants Regulation Relative (related person)Reporting Research Research Personnel Resources Role RyR2 Sampling Schedule Science Scientist Score Series Shapes Signal Transduction Simulate Site Slide Solid Solutions Son Source Staging Stimulus Structure Structure of beta Cell of islet Structure of purkinje fibers Students Suggestion Supervision System Systems Theory Techniques Technology Testing Text Thumb structure Time Time Study Training Universities Update Validation Variant Ventricular Voice Week Whole-Cell Recordings Work Writing adrenergic animation artist atrioventricular node base body system cell type channel blockers computer science concept cost day design experience feeding heart metabolism improved in vivo insight instructor interest journal article lecture notes lecturer lectures markov model medical schools member mitochondrial membrane models and simulation molecular imaging multi-scale modeling nanoscale patch clamp professor programs protein expression protein structure repository research study response simulation skills software development statistics success teacher theories tool transmission process vector virtual voltage voltage clamp

项目摘要

DESCRIPTION (provided by applicant): The short course "Integrative Models of the Cardiac Myocyte" will train biomedical researchers and clinician-scientists in how to develop and apply biophysically- and biochemically-detailed, experimentally-based computational models of the cardiac myocyte. Emphasis will be on modular development and testing of models using experimental data, numerical methods for solving model equations, mathematical techniques for developing and solving multi-scale models of the cell and methods for analyzing parameter sensitivity of models. The approach to this course is that developed by Dr. Harry Goldberg and which is being incorporated extensively into the JHU School of Medicine curriculum. In this approach, cd-rom and/or web-based learning modules are developed and provided to students prior to lecture. These learning modules present the core material for each lecture. Lectures are then used as an opportunity for direct interaction with students, to address questions on the core material and to apply or delve more deeply into the core material. These learning modules will be developed using Macromedia Breeze and will be available to everyone via the web. Instructional materials on how to create new learning modules will be created, thus enabling the cardiovascular research community to download existing learning modules, and generate new learning modules of their own design which may be added to their instantiation of the web course in order to meet local educational needs.

描述（由申请人提供）：简短的课程“心肌细胞的综合模型”将培训生物医学研究人员和临床医生，以如何开发和应用生物物理和生化详细的，实验性的心肌细胞计算模型。强调使用实验数据，用于求解模型方程的数值方法，用于开发和求解细胞的多规模模型的数学方法的模块开发和测试，以及分析模型参数敏感性的方法。该课程的方法是由哈里·戈德堡（Harry Goldberg）博士开发的，并将其广泛纳入JHU医学院课程。在这种方法中，在演讲前开发并提供了基于网络的学习模块和/或基于Web的学习模块。这些学习模块呈现每个讲座的核心材料。然后，讲座被用作与学生直接互动的机会，以解决有关核心材料的问题，并更深入地应用或深入研究核心材料。这些学习模块将使用Macromedia Breeze开发，并通过网络使用。将创建有关如何创建新学习模块的教学材料，从而使心血管研究社区能够下载现有的学习模块，并生成自己设计的新学习模块，这些模块可以添加到网络课程的实例化中，以满足当地的教育需求。