PATHOLOGY SUPPORT FOR THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

国家环境健康科学研究所的病理学支持

• 批准号: 8845123
• 负责人: JAMES MORRISON
• 金额: $ 382.5万
• 依托单位: CHARLES RIVER LABORATORIES INTNTL, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845123
• 关键词: American; Anatomy; Animal Model; Animals; Apoptosis; Biological Assay; CDKN2A gene; Cell Proliferation; Cells; Chemical Agents; Chemicals; Chronic; Clinical Pathology; Collaborations; Communities; Data; Diagnosis; Documentation; Dose; Electron Microscopy; Ensure; Environment; Evaluation; Evaluation Studies; Exposure to; Generations; Goals; Hazardous Chemicals; Health; Health protection; Housing; Human; Hybrids; Immunohistochemistry; Inbred F344 Rats; Knockout Mice; Lesion; Literature; Measurement; Medical; Molecular; Mouse Strains; Mus; Mutation; National Cancer Institute; National Institute for Occupational Safety and Health; National Institute of Environmental Health Sciences; National Toxicology Program; Nature; Organ; Pathologist; Pathology; Phase; Private Sector; Procedures; Protocols documentation; Publishing; Qualifying; Reporting; Research; Research Personnel; Rodent; Role; Science; Slide; System; Terminology; Testing; Tissues; Toxic effect; Toxicology; Transgenes; Transgenic Mice; United States Dept. of Health and Human Services; United States Public Health Service; Work; animal resource; base; carcinogenesis; carcinogenicity; diagnostic accuracy; high standard; improved; programs; sex; working group

The National Toxicology Program (NTP) was established as a cooperative effort within the Public Health Service (PHS) of the Department of Health and Human Services (DHHS) to coordinate and manage toxicological research and testing activities within the Department, to provide scientific information on potentially hazardous chemicals to regulatory and research agencies, scientific and medical communities, and the public, and to strengthen the science base in toxicology. This interagency program comprises one of the world's largest scientific data resources for animal toxicity/carcinogenicity studies. The NTP consists of the relevant toxicological activities of the National Institute of Environmental Health Sciences, the National Institute for Occupational Safety and Health, the National Cancer Institute, and the National Center for Toxicological Research. Through its activities, the NTP provides either directly or indirectly, a large component of the basic scientific data that other Federal and State scientific and regulatory agencies as well as private sector organizations utilize in responding to issues relevant to the effects of chemicals on human health and the environment. Thus, the ultimate role of the NTP in the research and testing of chemicals and agents is the protection of health of the American public from exposure to hazardous chemicals.

国家毒理学计划（NTP）是作为卫生和人类服务部（DHHS）公共卫生服务（PHS）内的合作努力而建立的，以协调和管理该部门内的毒理学研究和测试活动，向监管和研究机构，科学和医学界以及公众提供有关潜在危险化学品的科学信息，并加强毒理学的科学基础。该跨部门计划包括世界上最大的动物毒性/致癌性研究科学数据资源之一。NTP由国家环境健康科学研究所、国家职业安全与健康研究所、国家癌症研究所和国家毒理学研究中心的相关毒理学活动组成。通过其活动，国家结核控制方案直接或间接地提供了基础科学数据的很大一部分，供其他联邦和州科学和管理机构以及私营部门组织在应对化学品对人类健康和环境的影响问题时使用。因此，NTP在化学品和制剂研究和测试中的最终作用是保护美国公众的健康，使其免受危险化学品的危害。