Water-Equivalent Plastic Scintillation Detectors for Small-Field Radiotherapy

用于小场放射治疗的水当量塑料闪烁探测器

• 批准号: 8708775
• 负责人: Sam Beddar
• 金额: $ 52.32万
• 依托单位: STANDARD IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-10 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708775
• 关键词: Algorithms; B Fibers; Benchmarking; Caliber; Calibration; Cations; Characteristics; Clinical; Color; Complex; Coupled; Data; Development; Devices; Dose; Effectiveness; Equipment; Evaluation; Fiber; Generations; Goals; Government; Image; Individual; Intensity-Modulated Radiotherapy; Length; Libraries; Marketing; Measurement; Measures; Medical; Methods; Modality; Noise; Optics; Organ; Output; Patient Care; Patients; Performance; Persons; Phase; Physics; Planet Mars; Plastics; Radiation; Radiation therapy; Radiosurgery; Reporting; Risk; Scanning; Signal Transduction; System; Techniques; Technology; Testing; Therapeutic; Time; Tissues; Treatment Protocols; Water; analog; clinical application; commercialization; design; detector; dosimetry; improved; ionization; lens; miniaturize; optical fiber; patient safety; phase 2 study; public health relevance; radiation detector; treatment planning; tumor; user-friendly

DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry. These small detectors are needed in clinical applications such as stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT), intensity modulated radiation therapy (IMRT), dynamic arc therapy, and tomotherapy treatments. The enabling technology is the point scintillation detector that employs a miniature plastic scintillator coupled to a color PIN diode detector via an optical fiber. Small field radiotherapy techniques such as stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT) enable delivery of high radiation doses to tumors while sparing healthy tissue and organs at risk. These special and complex treatment modalities significantly benefit patients and offer substantial advantages over traditional radiotherapy techniques. Because SRS and SBRT treatments often deliver the entire therapeutic dose in a single or hypofractionated treatment regimen, the treatments must be delivered accurately. Phase I generated a robust, single-point water-equivalent scintillation dosimeter to accurately characterize and measure the dosimetry of small fields and to verify these special treatments before delivery. The compact, fully operational Plastic Scintillation Detector (PSD) is further enhanced when paired with Standard Imaging's dual-channel SuperMAX electrometer. However, the PSD/SuperMAX electrometer system cannot yet be used with water scanning systems because it lacks a compatible analog signal output. Coordinated use of a water scanning system with SRS-appropriate detectors is crucial to characterize these precise radiation fields accurately and efficiently before patient treatment. The overall goal of this Phase II project is to transition th Phase I small-field detector from a bench-top system requiring a specialized 2-channel electrometer to a versatile fully commercialized medical radiation detector. Achieving this goal will advance the successful Phase I project by (1) greatly expanding the effectiveness and market potential of PSD devices by developing a universally compatible detector system that could be fully used in place of an ionization chamber or diode with existing medical radiation measurement equipment, especially water scanning systems, (2) thoroughly optimizing the detector, and (3) fully characterizing the detector for easy application in typical clinical settins. At the successful completion of this Phase II study, Standard Imaging will be poised to deliver to the market a well-characterized PSD suitable for precise dosimetry and QA of small fields used in SRS and SBRT, and that is fully compatible with existing measurement systems. Further development of this single-point system subsequently could include generating multi-point systems such as 2D arrays for patient dosimetry or fixed linear arrays for water scanning.

描述（由申请人提供）：标准成像公司正在开发新一代辐射剂量计，用于小范围剂量测定。这些小型探测器用于临床应用，如立体定向放射外科/立体定向放疗（SRS/SRT）、调强放射治疗（IMRT）、动态电弧治疗和断层治疗。使能技术是点闪烁探测器，该探测器采用微型塑料闪烁体，通过光纤与彩色PIN二极管探测器耦合。立体定向放射外科（SRS）或立体定向全身放射治疗（SBRT）等小场放射治疗技术能够向肿瘤提供高剂量的辐射，同时使健康组织和器官处于危险之中。这些特殊和复杂的治疗方式使患者显著受益，并提供了比传统放射治疗技术更大的优势。由于SRS和SBRT治疗通常在单一或低分割治疗方案中提供整个治疗剂量，因此必须准确地提供治疗。第一阶段生产了一个强大的单点水等效闪烁剂量计，以准确表征和测量小油田的剂量，并在交付前验证这些特殊处理。当与Standard Imaging的双通道SuperMAX静电计配对时，结构紧凑，功能齐全的塑料闪烁检测器（PSD）进一步增强。然而，PSD/SuperMAX静电计系统还不能与水扫描系统一起使用，因为它缺乏兼容的模拟信号输出。在患者治疗前，协调使用水扫描系统与合适的srs探测器对于准确有效地表征这些精确的辐射场至关重要。第二阶段项目的总体目标是将第一阶段的小场探测器从需要专门的2通道静电计的台式系统转变为多功能的完全商业化的医疗辐射探测器。实现这一目标将通过以下方式推进第一阶段项目的成功：(1)通过开发一种普遍兼容的探测器系统，大大扩展PSD设备的有效性和市场潜力，该系统可以完全取代电离室或二极管与现有的医疗辐射测量设备，特别是水扫描系统，(2)彻底优化探测器，(3)充分表征探测器，以便于在典型的临床环境中应用。在二期研究成功完成后，Standard Imaging将准备向市场提供一种特性良好的PSD，适用于SRS和SBRT中使用的小领域的精确剂量测定和质量保证，并且与现有的测量系统完全兼容。这种单点系统的进一步发展随后可能包括产生多点系统，例如用于患者剂量测定的二维阵列或用于水扫描的固定线性阵列。