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Prompt Gamma Imaging for the in-vivo range verification during proton radiotherapy

用于质子放射治疗期间体内范围验证的即时伽玛成像

基本信息

批准号：
9750640
负责人：
Sam Beddar
金额：
$ 50.74万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-25 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9750640
关键词：
Anatomy Cancer Center Cell Nucleus Characteristics Clinical Collaborations Computer software Deposition Detection Development Diagnostic radiologic examination Dimensions Discrimination Dose Elements Ensure Evaluation Evaluation Studies Gamma Cameras Gamma Rays Goals Image Imaging technology Individual Location Measurement Measures Monitor Organ Patients Pilot Projects Proton Radiation Protons Quality of life Radiation Radiation therapy Real-Time Systems Research Roentgen Rays Safety Signal Transduction System Techniques Therapeutic Time Tissues Translating Translations Uncertainty Work X-Ray Computed Tomography base clinical application cone-beam computed tomography design detector image reconstruction image registration imaging modality imaging system improved in vivo in vivo imaging in vivo imaging system in vivo monitoring industry partner irradiation novel optimal treatments proton beam proton therapy prototype public health relevance radiation risk real-time images reconstruction response tumor

项目摘要

DESCRIPTION (provided by applicant): The full potential of proton therapy cannot be fully exploited due to uncertainties in the dose deposition characteristics of individual proton treatment beams caused by patient set-up errors, day- to-day changes in patient anatomy, and the overall response of irradiated tissues over the course of treatment. Therefore, current standard proton treatment techniques include the use of larger than desirable "treatment margins" and "safety margins" to ensure proper dose is delivered to the tumor in the presence of these uncertainties. The need for these large margins severely limits our ability to exploit the proton Bragg Peak's sharp dose gradients, thus reducing the full clinical potential of proton radiation therapy. Therefore, in order to fully exploit the advantages of the proton Bragg peak, there is a significant and critical need to reduce proton beam range uncertainties, allowing for the reduction of safety margins and the use of more optimal treatment beams, thus allowing the physical advantages of the proton Bragg peak to be exploited. Fortunately, inherent to proton therapy is the emission of elemental `prompt' gamma rays (PG) due to non-elastic proton-nucleus interactions in irradiated tissues. Each element in tissue emits a unique spectrum of PG energies along the path of the beam in the patient, making it a prime signal for beam range verification. We hypothesize that if PG emission during treatment delivery could be adequately measured and imaged, it would allow for the direct verification of the delivered beam range in-vivo. Our long-term goal is to improve the accuracy and precision of proton radiotherapy by monitoring the beam range and tissue response to irradiation in- vivo. To reach this goal, we have established a working academic-industrial partnership dedicated to the translation of our prototype prompt gamma imaging (PGI) system into a clinically viable system. The specific aims of this proposal are to: (1) build an efficient PG detection system, (2) develop a clinical platfor for PG image display and evaluation, and (3) characterize the functionality and perform initial pilot/evaluation studies our PGI system during patient treatment delivery. The proposed research will result in the development of a clinical PGI system for in-vivo imaging during proton radiotherapy treatment delivery. This will allow the measurement of the actual in-vivo dose delivery, thus reducing the inherent uncertainty in proton beam range. By measuring and verifying the beam range, we can reduce or even eliminate the need for large "treatment safety" margins to account for range uncertainty as a means of ensuring treatment safety and accuracy.

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Feasibility Studies of a New Event Selection Method to Improve Spatial Resolution of Compton Imaging for Medical Applications.

DOI：
10.1109/trpms.2017.2703095
发表时间：
2017-07
期刊：
IEEE transactions on radiation and plasma medical sciences
影响因子：
4.4
作者：
Draeger E;Peterson S;Mackin D;Chen H;Beddar S;Polf JC
通讯作者：
Polf JC

The effects of Compton camera data acquisition and readout timing on PG imaging for proton range verification.

DOI：
10.1109/trpms.2021.3057341
发表时间：
2022-03
期刊：
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
影响因子：
4.4
作者：
Polf, Jerimy C.;Maggi, Paul;Panthi, Rajesh;Peterson, Stephen;Mackin, Dennis;Beddar, Sam
通讯作者：
Beddar, Sam

3D prompt gamma imaging for proton beam range verification.