Global cortical dynamics in sleep and general anesthesia

睡眠和全身麻醉中的整体皮质动态

• 批准号: 8849552
• 负责人: ERAN A MUKAMEL
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8849552
• 关键词: Action Potentials; Address; Affect; Anesthesia procedures; Animal Model; Auditory; Auditory Evoked Potentials; Base of the Brain; Biological Markers; Biophysics; Brain; Brain Part; Brain imaging; Brain region; Clinic; Clinical Treatment; Collaborations; Communication; Conflict (Psychology); Coupling; Data; Data Analyses; Diagnosis; Dimensions; Disease; Electrocorticogram; Electrodes; Electroencephalography; Epilepsy; Esthesia; Event; Event-Related Potentials; General Anesthesia; Head; Health; Hour; Human; Implant; Individual; Intractable Epilepsy; Knowledge; Lead; Magnetic Resonance Imaging; Magnetism; Magnetoencephalography; Maps; Measures; Medicine; Mentors; Methods; Microelectrodes; Microscopic; Mining; Modeling; Modern Medicine; Monitor; Nature; Neural Network Simulation; Neurobiology; Neurologist; Neurons; Neurosciences; Neurosurgeon; Patient Monitoring; Patients; Pattern; Phase; Physiological; Physiology; Propofol; Recovery; Research; Resolution; Sensory Process; Signal Transduction; Site; Sleep; Source; Stereotyping; Structure; Techniques; Testing; Thalamic structure; Time; Tissues; Unconscious State; Validation; Work; abstracting; auditory stimulus; base; biophysical model; computational neuroscience; density; design; human subject; imaging modality; insight; man; millisecond; neuroimaging; neuroregulation; reconstruction; relating to nervous system; response; signal processing; stimulus processing; tool

Project Summary/Abstract The proposed research combines biophysics, statistical signal processing, computational data analysis, and neurobiology, to address a fundamentally interdisciplinary problem: How are global brain states organized? The brain's ability to operate in distinct global states, including waking, sleep, and general anesthesia, is critical for human health and medicine. This project aims to understand how cortical networks, interacting via millisec- ond-scale electrical signals, self-organize over macroscopic spatial dimensions to sustain global states for minutes to hours. In humans, electro- and magnetoencephalography (EEG, MEG) and intracranial electrocorti- cography (ECoG) probe neural dynamics with ms-scale resolution, but interpretation is challenging due to the ambiguity of their microscopic current sources. This project will use new, computationally sophisticated analy- ses and realistic biophysical modeling, combined with large-scale physiological recordings, to provide insight into the nature of cortical neural activity, in particular the global organization of sleep and general anesthesia. The mentored postdoctoral phase will build on preliminary results from electrophysiological studies of hu- man cortical dynamics during induction of general anesthesia. By using advanced statistical signal processing of high-density EEG recordings, this research showed that the unconscious brain during general anesthesia generates two categorically distinct types of rhythmic activity. These patterns are indistinguishable by classical power spectral methods and hence were not observed previously. These results indicate propofol general an- esthesia is not a unitary state, but comprises multiple global mode. The implications of these findings will be pursued by analyzing how auditory stimulus processing is altered during each state of unconsciousness evoked by propofol general anesthesia. Through computational and statistical analysis of cortical event-related potentials this project will probe the time course of neural activity following controlled auditory events to test whether the induction and emergence from anesthesia modulate sensory processing differentially. The preliminary results obtained in these studies will lead directly to the R00 independent research. Using intracranial recordings, obtained from patients implanted with arrays of electrodes in the course of treatment for epilepsy, this study will provide the first map in humans of the fine-scale spatial organization of specific activity patterns associated with general anesthesia. The propagation of currents and magnetic flux through the multi- ple layers of dielectric tissue in the head of a human subject will be measured empirically. Finally, the knowl- edge and tools resulting from these studies of general anesthesia will be leveraged to investigate the organiza- tion of rhythmic activity in physiological sleep, specifically aiming to test a new hypothesis for the circuit under- lying sleep spindles. Together, these studies will provide an empirically validated framework for understanding the global organization of neuronal activity throughout the brain within waking and unconscious states.

项目摘要/摘要 拟议的研究结合了生物物理学、统计信号处理、计算数据分析和 神经生物学，以解决一个根本的跨学科问题：全球大脑状态是如何组织的？ 大脑在不同的全局状态下工作的能力是至关重要的，包括清醒、睡眠和全身麻醉 为了人类的健康和医学。该项目旨在了解大脑皮层网络如何通过毫秒级交互- 超尺度电信号，在宏观空间维度上自组织，以维持全球状态 几分钟到几小时。在人类中，脑电和脑磁图(EEG，MEG)和颅内皮层脑电(EEG，MEG)和脑电地形图(EEG，MEG)和脑电地形图 脑电地形图(ECoG)探测具有毫秒级分辨率的神经动力学，但由于 其微观电流源的模糊性。该项目将使用新的、计算复杂的分析- SE和逼真的生物物理建模，结合大规模生理记录，提供洞察力 研究皮质神经活动的本质，特别是睡眠和全身麻醉的全球组织。 指导博士后阶段将建立在胡舒立电生理学研究的初步结果基础上。 全麻诱导过程中人的大脑皮质动力学。通过使用高级统计信号处理 在高密度脑电记录中，这项研究表明，全麻期间的无意识大脑 产生两种截然不同的节奏性活动。这些模式在古典音乐中是难以区分的 功率谱方法，因此以前没有观察到。这些结果表明异丙酚是一种全身麻醉方法。 知觉不是一种单一的状态，而是由多种整体模式构成的。这些发现的影响将是 通过分析在无意识的每一种状态下听觉刺激处理是如何改变的 由异丙酚全身麻醉引起。通过计算和统计分析大脑皮层相关事件 潜力这个项目将探索受控听觉事件后神经活动的时间进程以进行测试 麻醉诱导和苏醒是否以不同的方式调节感觉加工。 在这些研究中获得的初步结果将直接导致R00的独立研究。vbl.使用 在治疗过程中植入电极阵列的患者的颅内记录 癫痫，这项研究将首次提供人类精细空间组织的特定活动图 与全身麻醉相关的模式。电流和磁通量通过多个介质的传播 人体受试者头部的多层介电组织将被经验地测量。最后，知道-- 这些全身麻醉研究的优势和工具将被用来调查组织- 生理睡眠中的节律性活动，特别是旨在检验一种新的假说，即在... 躺在床上睡纺锤。总之，这些研究将提供一个经验性验证的理解框架 在清醒和无意识状态下，整个大脑的神经元活动的整体组织。