Co-construction of lexica in primary progressive aphasia
原发性进行性失语的词汇共构
基本信息
- 批准号:8764466
- 负责人:
- 金额:$ 23.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-01 至 2016-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAdvocateAffectAlgorithmsAlzheimer&aposs DiseaseAppleClinicalClinical ResearchCognitiveCommunicationCommunication Aids for DisabledCommunitiesComprehensionComputer softwareDataDatabasesDementiaDevelopmentDevicesDiagnosisElectronicsExperimental DesignsFamily memberFinancial compensationGoalsGuidelinesImageImpairmentIndividualInsuranceInterventionIntervention StudiesLanguageLanguage DisordersMeasuresMedicalMetadataMiningNamesNatural Language ProcessingOregonOutcomeParticipantPatientsPersonsPhasePilot ProjectsPopulationPrimary Progressive AphasiaProsthesisPublished CommentRecruitment ActivityResearchResearch Project GrantsSecondary toSelf-Help DevicesSemanticsSimulateSocial NetworkSodium ChlorideStagingStructureSyndromeTabletsTechniquesTechnologyTestingTranscriptVariantVisualVocabularyWithdrawalalternative communicationbaseclinical carecomputer sciencedesigndigitalexperiencehandheld mobile deviceimprovedinnovationinnovative technologiesintervention effectlexicalmobile applicationnovelpublic health relevanceresearch studyskillssocialtool
项目摘要
DESCRIPTION (provided by applicant): Individuals with primary progressive aphasia (PPA) present with an insidious onset and gradual loss of word finding, object naming, or word-comprehension skills which profoundly affect their verbal participation in daily activities. The overall goal of this innovative research is to take an initial step toward the creation of adaptive
language prostheses that augment lexical access and word use in PPA as skills are lost. The short term objective is to determine whether individuals with mild-to-moderate PPA improve or maintain word finding skills during conversation when provided with a novel intervention tool, namely a mobile technology application called CO-CHAT that automatically presents related vocabulary to them as needed. CO-CHAT is a simulated social media app for research which creates lexical displays synthesized from a user's self-generated photos, comments from social network contacts, the device's metadata, and a curated list of key words generated with Natural Language Processing (NLP) techniques. Aim 1 addresses development of the simulated social media app with NLP applications. Aim 2 proposes a research study to determine whether people with PPA can use the CO-CHAT lexical displays to improve or maintain word finding skills in conversation. Two hypotheses will be tested: (1) The number (and percentage) of target words spoken by participants during conversations will increase when the CO-CHAT lexical displays are available~ (2) The number (and percentage) of questions needed by conversation partners to obtain information from participants about daily activities will decrease when the CO-CHAT lexical displays are available. Participants are 10 individuals with mild-to-moderate PPA (agrammatic or semantic variants) recruited from the Oregon Alzheimer's Disease Center. A withdrawal ABAB design with intra-subject and inter-subject replication is proposed. Each participant engages in community- based activities, taking photos and sending them to a simulated social network for comment. By relying on the technology's automatic manipulation of language, photos comments then are analyzed. Related words that are mined from large lexical semantic databases are placed in the lexical displays with the original photo. Participants describe the community activities to familiar partners in 5-minute conversations without technology (baseline phase A) and with CO- CHAT (experimental phase B). Visual analysis of changes across conditions and repeated measures ANOVAs evaluate intervention effects. The proposed research addresses the need to identify effective language compensation strategies to treat individuals experiencing PPA, a relatively new diagnosis for which compensatory treatment paradigms are yet to be developed. Results will support a larger research agenda to further develop adaptive assistive technologies for intervention, and to implement outcomes-based clinical studies that determine the efficacy of a stage-based longitudinal AAC/NLP intervention for patients with PPA in order to maintain vocabulary access, communication functions and social networks with mobile technology over the course of language degeneration.
描述(由申请人提供):患有原发性进行性失语症(PPA)的个体表现为潜伏性发病和逐渐丧失单词发现,物体命名或单词理解技能,这深刻影响了他们在日常活动中的言语参与。这项创新研究的总体目标是朝着创建适应性的
在PPA中增加词汇访问和单词使用的语言假体作为技能丢失。短期目标是确定当提供一种新的干预工具时,轻度至中度PPA患者在对话期间是否改善或保持单词查找技能,即称为CO-CHAT的移动的技术应用程序,该应用程序根据需要自动向他们提供相关词汇。CO-CHAT是一款用于研究的模拟社交媒体应用程序,它创建了由用户自己生成的照片,社交网络联系人的评论,设备的元数据以及使用自然语言处理(NLP)技术生成的关键词的精选列表合成的词汇显示。目标1解决了使用NLP应用程序开发模拟社交媒体应用程序。目的2提出了一项研究,以确定是否与PPA的人可以使用CO-CHAT词汇显示,以提高或保持在对话中的单词查找技能。将检验两个假设:(1)当CO-CHAT词汇显示可用时,会话参与者在会话期间说出的目标词的数量(和百分比)将增加~(2)当CO-CHAT词汇显示可用时,会话伙伴从参与者获取关于日常活动的信息所需的问题的数量(和百分比)将减少。参与者是从俄勒冈州阿尔茨海默病中心招募的10名患有轻度至中度PPA(语法或语义变体)的个体。一个退出ABAB设计与受试者内和受试者间的复制。每个参与者都参与基于社区的活动,拍摄照片并将其发送到模拟社交网络进行评论。借助该技术对语言的自动处理,对照片评论进行分析。从大型词汇语义数据库中挖掘的相关词汇与原始照片一起放置在词汇显示中。参与者在5分钟的对话中向熟悉的合作伙伴描述社群活动,没有技术(基线阶段A)和CO-CHAT(实验阶段B)。对不同条件和重复测量的变化进行视觉分析,ANOVA评估干预效果。拟议的研究解决了需要确定有效的语言补偿策略来治疗个人经历PPA,一个相对较新的诊断,补偿治疗范式尚未开发。结果将支持更大的研究议程,以进一步开发用于干预的自适应辅助技术,并实施基于结果的临床研究,以确定PPA患者基于阶段的纵向AAC/NLP干预的有效性,以便在语言退化过程中使用移动的技术保持词汇访问,沟通功能和社交网络。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MELANIE FRIED-OKEN其他文献
MELANIE FRIED-OKEN的其他文献
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{{ truncateString('MELANIE FRIED-OKEN', 18)}}的其他基金
Translational refinement of adaptive communication system for locked-in patients
闭锁患者自适应通信系统的翻译细化
- 批准号:
8213637 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Translational refinement of adaptive communication system for locked-in patients
闭锁患者自适应通信系统的翻译细化
- 批准号:
7570367 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Clinic Interactions of a Brain-Computer Interface for Communication
用于通信的脑机接口的临床交互
- 批准号:
9233069 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
优化 BCI-FIT:脑机接口 - 功能实现工具包
- 批准号:
10678637 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Translational refinement of adaptive communication system for locked-in patients
闭锁患者自适应通信系统的翻译细化
- 批准号:
8413778 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Clinic Interactions of a Brain-Computer Interface for Communication
用于通信的脑机接口的临床交互
- 批准号:
9038348 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Translational refinement of adaptive communication system for locked-in patients
闭锁患者自适应通信系统的翻译细化
- 批准号:
7743573 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Translational refinement of adaptive communication system for locked-in patients
闭锁患者自适应通信系统的翻译细化
- 批准号:
8020057 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Ethical Considerations for Language Modeling within Brain-Computer Interfaces
脑机接口中语言建模的伦理考虑
- 批准号:
9929337 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
优化 BCI-FIT:脑机接口 - 功能实现工具包
- 批准号:
10442719 - 财政年份:2009
- 资助金额:
$ 23.48万 - 项目类别:
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