NIAMS Multidisciplinary Clinical Research Center

建议的加州大学旧金山分校多学科临床研究中心计划(UCSF MCRC)的广泛目标是通过发现影响这些结果的医疗、人口和背景因素来改善各种形式的风湿病患者的结果。这一总体目标是通过风湿病临床研究的全面计划来实现的，包括但不限于MCRC内的研究；作为整个加州大学旧金山分校此类临床研究的催化剂；以及对风湿病临床研究人员的系统培训。 MCRC包括一个行政股、方法核心、四个五年期项目和一项为期三年的发展和可行性研究。MCRC的参与者跨越加州大学旧金山分校的三所学校(医学、护理和牙科)和加州大学戴维斯分校，包括加州大学旧金山分校GCRC在内的九个独立学术单位的代表。该中心的主任和副主任分别是爱德华·叶林博士和林赛·克里斯韦尔博士。核心单位主任是Patricia Katz博士。多民族玻利维亚国的活动由一个执行委员会日常指导。该中心的战略监督由内部(加州大学旧金山分校)和外部咨询委员会提供。该中心还将有一名导师 我们最资深的前实习生委员会，现在都是加州大学旧金山分校和其他三所医学院的学术医学专业的学生，研究生理事会。 MCRC的研究是基于对系统性红斑狼疮(SLE)和类风湿关节炎(RA)这两种特定疾病的纵向原始数据的分析。主要数据，狼疮结果研究和类风湿性关节炎结果研究，在MCRC项目中共享。这两个数据集的设计和实施是在方法核心单位进行的。核心单位还负责提供生物统计学咨询，并在新兴分析方法方面指导教职员工。 具体的五年期项目是：项目1：遗传学、血统和系统性红斑狼疮结局(Lindsey Criswell，P.I.)；项目2：肥胖和体力活动对RA和SLE患者抑郁的影响(Patricia Katz，P.I.)；以及项目3：影响SLE弱势人群结局的卫生保健因素(Edward Yelin，P.I.)。D&F的研究是：开发一种定制的症状评估工具来加强RA以患者为中心的护理(Jennifer Barton，P.I.)。

The broad aim of the proposed UCSF Multidisciplinary Clinical Research Center Program (UCSF MCRC) is to improve outcomes for persons with various forms of rheumatic diseases by discovery of the medical, demographic, and contextual factors affecting those outcomes. This overarching aim is pursued by a comprehensive program of clinical research in the rheumatic diseases, including but not limited to that within the MCRC; by serving as a catalyst for such clinical research throughout UCSF; and by systematic training of clinical investigators in the rheumatic diseases. The MCRC consists of an Administrative Unit, Methodology Core, four five-year projects, and a three-year Development and Feasibility (D&F) Study. The participants in the MCRC span three UCSF schools (Medicine, Nursing, and Dentistry) and UC, Davis and include representatives of nine discrete academic units, including the UCSF GCRC. The Center's Director and Associate Director are Drs. Edward Yelin and Lindsey Criswell, respectively. The Director of the Core Unit is Dr. Patricia Katz. The activities of the MCRC are guided on a day-to-day basis by an Executive Committee. Strategic oversight of the Center is provided by Internal (UCSF) and External Advisory Committees. The Center will also have a mentorship committee of our most senior former trainees, now all in academic medicine at UCSF and three other medical schools, the Graduates' Council. The research of the MCRC is based on analysis of longitudinal primary data about two specific diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The primary data, the Lupus Outcomes Study, and the Rheumatoid Arthritis Outcomes Study, are shared across MCRC projects. Design and implementation of these two datasets occurs in the Methodology Core Unit. The Core Unit is also repsonsible for biostatistical consulting and mentorship of faculty and fellows in emerging methods of analysis. The specific five-year projects are: Project 1: Genetics, Ancestry, and SLE Outcomes (Lindsey Criswell, P.I); Project 2: The Impact of Obesity and Physical Activity on Depression in RA and SLE (Patricia Katz, P.I.); and Project 3: Health Care Factors Affecting Outcomes of Vulnerable Populations with SLE (Edward Yelin, P.I.). The D&F Study is: The Development of a Tailored Symptom Assessment Tool to Enhance Patient-Centered Care in RA (Jennifer Barton, P.I.).