Novel nano-mechanical platform to investigate therapeutic sub-cellular mechanical

研究治疗性亚细胞力学的新型纳米力学平台

• 批准号: 8518099
• 负责人: Rupak M Rajachar
• 金额: $ 6.99万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8518099
• 关键词: Address; Adhesions; Affect; Area; Behavior; Biocompatible Materials; Biological; Cell Adhesion; Cells; Chemicals; Coupled; Deterioration; Development; Devices; Environment; Exploratory/Developmental Grant; Fibroblasts; Film; Frequencies; Gene Expression; Goals; Immune response; Implant; In Situ; In Vitro; Investigation; Lead; Mechanics; Modeling; Monitor; Morphology; Myofibroblast; Play; Property; Real-Time Systems; Research Project Grants; Role; Site; Stimulus; Surface; Surface Properties; System; Systems Development; Technology; Testing; Therapeutic; Therapeutic Effect; Time; Tissues; Ultrasonography; United States National Institutes of Health; base; cell behavior; cell type; clinical application; implantable device; implantation; improved; in vivo; interest; macrophage; nano; neutrophil; novel; novel strategies; research study; response; seal; submicron; surface coating; tool; vibration

DESCRIPTION (provided by applicant): This project seeks support for the development of a novel mechanically responsive material system to study the relationship between local cell-level mechanical perturbation and cell response to chemical-physical biomaterial surface properties. The coating is based on a magnetoelastic material that can be remotely set to vibrate at a predetermined amplitude and profile. We hypothesize that local sub-cellular mechanical stimulus can be used to optimize substrate-cellular interactions to improve the long-term stability at the tissue-implant interface. Ultimately we hope to use these coatings as a real-time system for modulation and monitoring the surface of implantable biomaterials. Preliminary experiments have indicated that submicron localized vibrations, such as those generated by the proposed vibration coating, could potentially be coupled with tailored biomaterial surface properties to selectively control cellular adhesion and gene expression to promote and maintain proper integration at the implant-tissue interface. The specific goal of this proposal is to characterize the relationship between small local vibrations, substrate material surface character, and concomitant cellular response to applied vibrations.

描述（由申请人提供）：本项目寻求支持开发一种新型机械反应材料系统，以研究局部细胞水平的机械扰动与细胞对化学物理生物材料表面特性的反应之间的关系。该涂层基于磁弹性材料，可以远程设置为以预定的振幅和轮廓振动。我们假设局部亚细胞机械刺激可用于优化基质-细胞相互作用，以提高长期稳定性