Laser-enhanced particle-free HIFU heating
激光增强无颗粒 HIFU 加热
基本信息
- 批准号:8509687
- 负责人:
- 金额:$ 6.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-15 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AblationAnimal ModelAreaBloodBlood CirculationBurn injuryContrast MediaDepositionDiagnosticEffectivenessFocused Ultrasound TherapyGoalsHead and Neck CancerHeatingHourImageImmune systemInjection of therapeutic agentLasersLeadLesionLifeMammary NeoplasmsMedicalMethodsMorbidity - disease rateNeedlesNeoplasm MetastasisOperative Surgical ProceduresOutcomeOutputPatientsPerioperativePostoperative PainProceduresProcessProstatic NeoplasmsRecoveryResearchResistanceRiskRodent ModelSkinSolid NeoplasmSonicationSurfaceSystemTechniquesTestingThermal Ablation TherapyTimeTissuesUltrasonicsUltrasonographyVascular blood supplyabsorptioncancer therapycostdesignimprovedmortalitynanoparticleparticlephotoacoustic imagingsuccesstumor
项目摘要
DESCRIPTION (provided by applicant): High intensity focused ultrasound (HIFU) therapy has emerged as a truly non-invasive medical procedure for solid tumor treatment. However, the volume of the lesion following a single HIFU sonication is small. As a result, it can take up to several hours to ablate a relatively small tumor. In addition, highly vascularized (perfused) tissues are more resistant to thermal ablation than poorly perfused areas owing to the cooling effect of blood circulation. Therefore, a prolonged heating duration will be required in highly vascularized tissues. Skin burns, which are usually limited to subcentimetre superficial burns, are also often observed after HIFU treatments because ultrasonic energy deposition reaches a local maximal at skin surface. To facilitate HIFU process and avoid or minimize skin burns, we need to enhance HIFU-induced heating in the targeted tissue at a relatively low ultrasound intensity level. The effectiveness of HIFU-induced heating is related to the local ultrasound absorption. The increase of ultrasound absorption in the targeted tissue can effectively improve the heating outcome of HIFU treatment. The injection of ultrasound contrast agents or nanoparticles into the targeted tissue has been studied as a method to increase the local ultrasound absorption and enhance HIFU heating. In the current project, we propose to evaluate a photo-enhanced particle-free technique to facilitate HIFU ablation. Our central hypothesis is that HIFU therapy can be improved by a diagnostic laser system without the injection of any micro-, or nano-particles into the body. We have two specific aims: 1) investigate and optimize photo- enhanced particle-free HIFU heating: ex vivo study; and 2) evaluate photo-enhanced particle-free HIFU heating in a rodent model. We believe that the success of the proposed research will lead to an enhanced HIFU therapy for solid tumor treatments, which include the treatment of breast tumors, prostate tumors, head and neck cancer.
描述(由申请人提供):高强度聚焦超声(HIFU)治疗已经成为一种真正的非侵入性治疗实体肿瘤的医疗程序。然而,单次HIFU超声检查后病变的体积很小。因此,切除一个相对较小的肿瘤可能需要几个小时。此外,由于血液循环的冷却作用,高度血管化(灌注)的组织比灌注不良的组织更能抵抗热消融。因此,在高度血管化的组织中需要延长加热时间。由于超声能量沉积在皮肤表面达到局部最大值,HIFU治疗后也经常观察到皮肤烧伤,通常仅限于亚厘米的浅表烧伤。为了促进HIFU过程,避免或尽量减少皮肤烧伤,我们需要在相对较低的超声强度水平下增强HIFU诱导的靶组织加热。hifu诱导加热的有效性与局部超声吸收有关。靶组织超声吸收的增加可以有效改善HIFU治疗的加热效果。研究了将超声造影剂或纳米颗粒注射到靶组织中,作为增加局部超声吸收和增强HIFU加热的方法。在目前的项目中,我们建议评估一种光增强无粒子技术,以促进HIFU消融。我们的中心假设是,在不向体内注射任何微或纳米颗粒的情况下,诊断激光系统可以改善HIFU治疗。我们有两个具体的目标:1)研究和优化光增强无粒子HIFU加热:离体研究;2)在啮齿动物模型中评估光增强无颗粒HIFU加热。我们相信,该研究的成功将导致HIFU治疗实体肿瘤的增强,包括乳腺肿瘤、前列腺肿瘤、头颈癌的治疗。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Enhanced cavitation by using two consecutive ultrasound waves at different frequencies.
通过使用不同频率的两个连续超声波来增强空化作用。
- DOI:10.1063/1.4902118
- 发表时间:2014
- 期刊:
- 影响因子:4
- 作者:Yang,Xinmai;Jo,Janggun
- 通讯作者:Jo,Janggun
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Xinmai Yang其他文献
Xinmai Yang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Xinmai Yang', 18)}}的其他基金
Precisely removing microvessels by photo-mediated ultrasound therapy
光介导超声治疗精准去除微血管
- 批准号:
10228017 - 财政年份:2018
- 资助金额:
$ 6.59万 - 项目类别:
Precisely removing microvessels by photo-mediated ultrasound therapy
光介导超声治疗精准去除微血管
- 批准号:
9769058 - 财政年份:2018
- 资助金额:
$ 6.59万 - 项目类别:
Photoacoustic imaging of functional domains on primary motor cortex of monkeys
猴子初级运动皮层功能域的光声成像
- 批准号:
8011214 - 财政年份:2010
- 资助金额:
$ 6.59万 - 项目类别:
Photoacoustic imaging of functional domains on primary motor cortex of monkeys
猴子初级运动皮层功能域的光声成像
- 批准号:
7774637 - 财政年份:2010
- 资助金额:
$ 6.59万 - 项目类别:
The assessment of brain functional alterations due to drug abuse/addiction with p
用 p 评估药物滥用/成瘾引起的脑功能改变
- 批准号:
7712732 - 财政年份:2009
- 资助金额:
$ 6.59万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Early-Career Scientists