Neurobehavioral assessments of RDoC domains to detect preschool mood disorders

RDoC 域的神经行为评估以检测学前情绪障碍

• 批准号: 8769323
• 负责人: Kate Dimond Fitzgerald
• 金额: $ 8.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8769323
• 关键词: 6 year old; Acute; Address; Adolescence; Adult; Affect; Age; Anxiety; Basic Science; Behavior; Behavior assessment; Behavioral; Biological Markers; Child; Child Behavior; Childhood; Chronic; Clinic; Clinical; Coin; Comorbidity; Complex; Data; Development; Diagnosis; Diagnostic; Dimensions; Disease; Early Intervention; Early identification; Ensure; Failure; Family; Feedback; Foundations; Fright; Funding; Future; Genes; Health; Health system; High Prevalence; Impairment; Infant; Intervention; Interview; Investigation; Life; Light; Link; Longevity; Maps; Measures; Mental Depression; Mental Health; Mental disorders; Michigan; Mood Disorders; Morbidity - disease rate; Morphologic artifacts; National Institute of Mental Health; Neurobiology; Nursery Schools; Onset of illness; Parents; Participant; Pathway interactions; Patients; Pattern; Pediatrics; Phenotype; Pilot Projects; Population; Preschool Child; Prevalence; Procedures; Process; Psychiatry; Psychopathology; Public Health; Recruitment Activity; Recurrence; Relative (related person); Reporting; Research; Research Domain Criteria; Research Personnel; Rewards; Risk; Sampling; Severities; Symptoms; Syndrome; Testing; Uncertainty; United States National Institutes of Health; Universities; Work; aged; base; child depression; childhood anxiety; childhood onset depression; clinical infrastructure; clinically significant; depressive symptoms; disease classification; early childhood; early onset; experience; functional disability; heuristics; improved; indexing; neural circuit; neurobehavioral; neurophysiology; relating to nervous system; treatment strategy

DESCRIPTION (provided by applicant): Childhood mood disorders represent a significant public health concern, with 6 to 11% of the population suffering from symptomology. Among those affected, 70% will have a recurrence during childhood and/or adolescence, and 50% will continue to experience symptoms in adulthood. These patterns of chronicity suggest that mental health problems observed later in life often have identifiable markers during early childhood. Therefore, early identification and intervention is critical. The NIH has put forth the Research Domain Criteria (RDoC), which acts as a heuristic to examine mechanisms of mental illness by suggesting the investigation of several behaviorally and biologically based processes. Although RDoC provides a valuable theoretical framework, the applicability of RDoC for developmental psychopathology research has been limited, primarily due to a lack of validated, feasible, standardized assessment batteries to examine RDoC domains in young children. Our aim is to create and validate behavioral and neurobiological assessments for young children in order to examine the relevance of RDoC domains, Positive and Negative Valence, for childhood depression and anxiety that often precedes or commingles with it. Specifically, we will study the constructs of reward valuation (Positive Valence) and acute threat (Negative Valence) using behavioral and neurophysiologic correlates of these constructs and test for associations with clinically assessed depression and anxiety in 4-6 year old children. Recruitment through the Infant and Early Childhood Clinic at the University of Michigan's Department of Psychiatry, as well as general pediatrics clinics in our health system, will ensure that a broad spectrum of anxiety and depressive symptoms, across the clinical to non-clinical range are represented in the children in our study. We seek NIH pilot funding to investigate the feasibility of behavioral and neurophysiology tasks that will long-term 1) inform assessment procedures, blending basic science advances with accessibility for patients and their families; 2) improve our characterization of underlying mechanisms of child anxiety and depression; and 3) inform subsequent interventions to address personalized child-level deficits. Findings will prove high impact as the NIMH considers the study and future application of RDoC criteria a high priority, and, yet, there are few empirical data exploring such application among young children. This proposal is responsive to the urgent need for validated, feasible, and standardized assessment batteries to examine RDoC domains in young children, and represents a critical step in a long-term plan to achieve effective and mechanism-based identification and treatment strategies for preschool-age children with depression and anxiety.

描述（由申请人提供）：儿童情绪障碍是一个重大的公共卫生问题，6%至11%的人口患有精神病。在受影响的人中，70%的人将在儿童和/或青春期复发，50%的人将在成年后继续出现症状。这些慢性模式表明，在生命后期观察到的心理健康问题往往在幼儿期有可识别的标记。因此，早期识别和干预至关重要。美国国立卫生研究院提出了研究领域标准（RDoC），它作为一个启发式的精神疾病的机制，建议调查的几个行为和生物学为基础的过程。虽然RDoC提供了一个有价值的理论框架，RDoC的发展精神病理学研究的适用性一直是有限的，主要是由于缺乏有效的，可行的，标准化的评估电池检查RDoC域在幼儿。我们的目标是为幼儿创建和验证行为和神经生物学评估，以检查RDoC域（正效价和负效价）与儿童抑郁和焦虑的相关性，这些抑郁和焦虑通常先于或混合在一起。具体而言，我们将研究奖励评估的结构，（正价）和急性威胁（负价）使用这些结构的行为和神经生理学相关性，并在4 - 6岁儿童中测试与临床评估的抑郁和焦虑的关联。通过密歇根大学精神病学系的婴儿和幼儿诊所以及我们卫生系统中的普通儿科诊所进行招募，将确保在我们研究的儿童中代表广泛的焦虑和抑郁症状，从临床到非临床范围。我们寻求NIH试点资金，以调查行为和神经生理学任务的可行性，这些任务将长期1）告知评估程序，将基础科学进步与患者及其家属的可访问性相结合; 2）改善我们对儿童焦虑和抑郁的潜在机制的表征; 3）告知后续干预措施，以解决个性化的儿童水平缺陷。研究结果将证明高影响，因为NIMH认为RDoC标准的研究和未来应用是一个高度优先事项，然而，很少有经验数据探索这种应用在幼儿中。这项建议是响应验证的，可行的，标准化的评估电池，以检查RDoC域在幼儿的迫切需要，并代表了一个长期计划，以实现有效的和基于机制的识别和治疗策略学龄前儿童抑郁症和焦虑症的关键一步。