Einstein PETAL: Clinical Center for the PETAL Network

描述（由申请人提供）：本提案的总体目标是在阿尔伯特爱因斯坦医学院下建立Einstein-PETAL，作为PETAL网络中的临床中心。Einstein-PETAL的具体目标是：1）通过建立重症监护和急诊医学之间的专业知识和既定合作，优化PETAL试验中不同患者人群的识别和招募。2)为了通过利用当地和国家的基础设施、资源以及研究中心和PI的专业知识（包括美国危重疾病和伤害试验组）来促进PETAL网络的效率和运作，CTSA支持爱因斯坦-蒙蒂菲奥里临床和转化研究所（ICTR）的多个核心，包括爱因斯坦-蒙蒂菲奥里ICTR临床研究信息学核心（RIC），和电子医疗记录3)为PETAL提出两项重要的临床试验（肺损伤预防清单（CLIP）和肺损伤预防研究阿司匹林II（LIPS-A II）），旨在预防ARDS和ARDS高危患者的死亡率。为了实现这些目标，我们在纽约市聚集了具有出色的临床和学术重症监护和紧急医学输送系统的机构。这些地点包括蒙蒂菲奥里医疗中心及其卫星地点西奈山医疗中心。这些位于曼哈顿和布朗克斯的医疗中心共有126张成人内科和外科重症监护病房床位，2012年收治了6,873名患者，一个忙碌咨询/快速反应团队每年接诊超过6,619名患者，是全国最繁忙的急诊室之一，每年有超过35万名成人就诊。临界 护理和急救医疗服务得到了强有力的机构研究基础设施和支持的补充。交付成果将包括：主要研究者和共同主要研究者（具有ARDS预防和紧急研究方面的专业知识）参与PETAL指导委员会，承诺在PETAL试验入组的5年半内每年入组40例患者，并按照我们的上述目标实施高质量和及时的研究程序以及数据和样本采集。

DESCRIPTION (provided by applicant): The overall aim of this proposal is to establish Einstein-PETAL under the Albert Einstein College of Medicine as a Clinical Center in the PETAL Network. The specific aims of Einstein-PETAL are: 1) To optimize the identification and recruitment of a diverse population of patients into PETAL trials by building upon the expertise and established collaboration between critical care and emergency medicine. 2) To facilitate the efficiency and operation of the PETAL Network by leveraging the local and national infrastructure, resources, and expertise of the sites and PIs, including the US Critical Illness an Injuries Trials Group, the CTSA supported Einstein- Montefiore Institute of Clinical and Translational Research (ICTR) with its multiple cores including the Einstein-Montefiore ICTR Clinical Research Informatics Core (RIC), and the electronic medical records at each site. 3) To propose for PETAL two significant clinical trials (Checklist for Lung Injury Prevention (CLIP) and Lung Injury Prevention Study Aspirin II (LIPS-A II)) aimed at the prevention of ARDS and mortality in patients at high risk for ARDS. To achieve these objectives, we have assembled institutions in New York City with outstanding clinical and academic critical care and emergency medicine delivery systems. These sites include the Montefiore Medical Center and its satellite site, the Mount Sinai Medical Center. Together these sites in Manhattan and the Bronx represent 126 adult medical and surgical intensive care unit beds that admitted 6,873 patients in 2012, a busy critical care consultative / rapid response team that sees over 6,619 patients a year, and one of the busiest EDs in the country with over 350,000 adult visits a year. The critical care and emergency medicine services are supplemented by strong institutional research infrastructure and support. The deliverables will include: participation of the PI and co-PI, with their expertise in ARDS prevention and emergency research, on the PETAL steering committees, a commitment to enroll 40 patients a year for the 5 1/2 years of enrollment into PETAL trials, and to implement high quality and timely study procedures and data and sample collection, as per our objectives above.