Einstein PETAL: Clinical Center for the PETAL Network

描述（由申请人提供）：本提案的总体目标是将爱因斯坦医学院下属的Einstein-PETAL建立为PETAL网络中的临床中心。Einstein-PETAL的具体目标是：1)通过建立重症监护和急诊医学之间的专业知识和已建立的合作，优化PETAL试验中不同患者群体的识别和招募。2)为了促进PETAL网络的效率和运作，利用当地和国家的基础设施、资源和站点和pi的专业知识，包括美国重大疾病和伤害试验小组，CTSA支持爱因斯坦-蒙蒂菲奥里临床和转化研究所（ICTR）的多个核心，包括爱因斯坦-蒙蒂菲奥里ICTR临床研究信息学核心（RIC），以及每个站点的电子医疗记录。3)为PETAL提出两项具有重要意义的临床试验（肺损伤预防检查表（CLIP）和肺损伤预防研究阿司匹林II (LIPS-A II)），旨在预防ARDS高危患者的ARDS和死亡率。为了实现这些目标，我们在纽约市集合了拥有优秀临床和学术重症监护和急诊医学交付系统的机构。这些地点包括蒙特菲奥里医疗中心及其卫星站点西奈山医疗中心。这些位于曼哈顿和布朗克斯的医院共有126张成人医疗和外科重症监护病房床位，2012年收治了6873名患者，是一个繁忙的重症监护咨询/快速反应团队，每年接待超过6619名患者，是全国最繁忙的急诊室之一，每年接待超过35万名成人就诊。的关键

DESCRIPTION (provided by applicant): The overall aim of this proposal is to establish Einstein-PETAL under the Albert Einstein College of Medicine as a Clinical Center in the PETAL Network. The specific aims of Einstein-PETAL are: 1) To optimize the identification and recruitment of a diverse population of patients into PETAL trials by building upon the expertise and established collaboration between critical care and emergency medicine. 2) To facilitate the efficiency and operation of the PETAL Network by leveraging the local and national infrastructure, resources, and expertise of the sites and PIs, including the US Critical Illness an Injuries Trials Group, the CTSA supported Einstein- Montefiore Institute of Clinical and Translational Research (ICTR) with its multiple cores including the Einstein-Montefiore ICTR Clinical Research Informatics Core (RIC), and the electronic medical records at each site. 3) To propose for PETAL two significant clinical trials (Checklist for Lung Injury Prevention (CLIP) and Lung Injury Prevention Study Aspirin II (LIPS-A II)) aimed at the prevention of ARDS and mortality in patients at high risk for ARDS. To achieve these objectives, we have assembled institutions in New York City with outstanding clinical and academic critical care and emergency medicine delivery systems. These sites include the Montefiore Medical Center and its satellite site, the Mount Sinai Medical Center. Together these sites in Manhattan and the Bronx represent 126 adult medical and surgical intensive care unit beds that admitted 6,873 patients in 2012, a busy critical care consultative / rapid response team that sees over 6,619 patients a year, and one of the busiest EDs in the country with over 350,000 adult visits a year. The critical care and emergency medicine services are supplemented by strong institutional research infrastructure and support. The deliverables will include: participation of the PI and co-PI, with their expertise in ARDS prevention and emergency research, on the PETAL steering committees, a commitment to enroll 40 patients a year for the 5 1/2 years of enrollment into PETAL trials, and to implement high quality and timely study procedures and data and sample collection, as per our objectives above.