Einstein PETAL: Clinical Center for the PETAL Network

描述(由申请人提供)：这项建议的总体目标是在阿尔伯特·爱因斯坦医学院下建立爱因斯坦-PEATL，作为PEATL网络中的临床中心。爱因斯坦-PEATAL的具体目标是：1)通过建立危重护理和急救医学之间的专业知识和已建立的合作，优化在PEATL试验中识别和招募不同人群的患者。2)为了促进PEATAL网络的效率和运作，利用当地和国家的基础设施、资源和网站和PI的专业知识，包括美国危重疾病和伤害试验小组，CTSA支持爱因斯坦-蒙特菲奥尔临床和转化研究所(卢旺达问题国际法庭)及其多个核心，包括爱因斯坦-蒙特菲奥尔卢旺达问题国际法庭临床研究信息学核心(RIC)和每个网站的电子医疗记录。3)为PEATAL提出两项重要的临床试验(肺损伤预防检查表(CLIP)和肺损伤预防研究阿司匹林II(LIPS-A II))，旨在预防ARDS和ARDS高危患者的死亡率。为了实现这些目标，我们在纽约市组建了拥有出色的临床和学术危重护理以及紧急药物输送系统的机构。这些地点包括蒙特菲奥里医疗中心及其卫星网站西奈山医疗中心。曼哈顿和布朗克斯的这些地点加在一起，代表着126个成人内外科重症监护病房床位，2012年收治了6873名患者；一个忙碌的危重护理咨询/快速反应团队，每年接诊超过6619名患者；以及全国最繁忙的急诊室之一，每年接诊超过35万名成人。关键人物 护理和紧急医疗服务得到强大的机构研究基础设施和支持的补充。交付成果将包括：PI和共同PI凭借其在ARDS预防和紧急研究方面的专业知识参与PEAL指导委员会，承诺在登记的5年半内每年招募40名患者参加PEATE试验，并按照我们以上目标实施高质量和及时的研究程序以及数据和样本收集。

DESCRIPTION (provided by applicant): The overall aim of this proposal is to establish Einstein-PETAL under the Albert Einstein College of Medicine as a Clinical Center in the PETAL Network. The specific aims of Einstein-PETAL are: 1) To optimize the identification and recruitment of a diverse population of patients into PETAL trials by building upon the expertise and established collaboration between critical care and emergency medicine. 2) To facilitate the efficiency and operation of the PETAL Network by leveraging the local and national infrastructure, resources, and expertise of the sites and PIs, including the US Critical Illness an Injuries Trials Group, the CTSA supported Einstein- Montefiore Institute of Clinical and Translational Research (ICTR) with its multiple cores including the Einstein-Montefiore ICTR Clinical Research Informatics Core (RIC), and the electronic medical records at each site. 3) To propose for PETAL two significant clinical trials (Checklist for Lung Injury Prevention (CLIP) and Lung Injury Prevention Study Aspirin II (LIPS-A II)) aimed at the prevention of ARDS and mortality in patients at high risk for ARDS. To achieve these objectives, we have assembled institutions in New York City with outstanding clinical and academic critical care and emergency medicine delivery systems. These sites include the Montefiore Medical Center and its satellite site, the Mount Sinai Medical Center. Together these sites in Manhattan and the Bronx represent 126 adult medical and surgical intensive care unit beds that admitted 6,873 patients in 2012, a busy critical care consultative / rapid response team that sees over 6,619 patients a year, and one of the busiest EDs in the country with over 350,000 adult visits a year. The critical care and emergency medicine services are supplemented by strong institutional research infrastructure and support. The deliverables will include: participation of the PI and co-PI, with their expertise in ARDS prevention and emergency research, on the PETAL steering committees, a commitment to enroll 40 patients a year for the 5 1/2 years of enrollment into PETAL trials, and to implement high quality and timely study procedures and data and sample collection, as per our objectives above.