Training Grant in Clinical Pharmacology

描述(由申请人提供)：本提案是对美国国立卫生研究院赞助的梅奥诊所-梅奥临床医学院-梅奥医学院临床药理学奖学金培训计划的持续资助的请求。该计划的基础是在应用于人与药物相互作用的最先进的生物医学技术方面进行强有力的研究培训。梅奥临床药理学培训经验包括一个课程，系统地让学员接触到作为临床药理学基础的科学的关键方面。培训的核心是在支持性的指导环境中获得出色的个人研究经验。临床药理学是一门致力于研究药物与生物系统相互作用的桥梁学科。然而，在生物医学科学正在发生的革命的背景下，这场革命有望改变医疗实践，临床药理学在于分子药理学、基因组学、蛋白质组学、生物信息学和合理疗法的融合--最终目标是真正的“个体化”药物治疗。具体地说，临床药理学致力于加强我们对药物反应的分子基础的了解，并在翻译界面上应用这些信息，使我们能够根据潜在的疾病过程和每个患者的独特特征量身定做药物治疗。我们有能力利用生物医学科学正在发生的巨大进步所代表的机会来实现这些目标，这将要求我们培训新一代临床药理学家，学习“系统临床药理学”。像梅奥诊所这样的大型、全面、综合的学术医疗中心是培养新一代临床药理学家的理想选择。梅奥之所以能够做到这一点，是因为它有着悠久的整合历史 梅奥临床药理学培训计划拥有数十年的成功招聘和培训经验，成功地招募和培训了临床药理学方面的内科科学家和实验室翻译科学家。在下一个资助周期中，梅奥临床药理学奖学金培训计划将继续强调在支持性的指导环境中进行强有力的基于实验室的研究培训，并系统地接触临床科学的发展，重点是生物医学科学的快速发展性质-所有这些都是为了使每个加入该计划的研究员准备成为未来临床药理学的领导者。

DESCRIPTION (provided by applicant): This proposal represents a request for continued funding of the NIH-sponsored Clinical Pharmacology Fellowship Training Program at the Mayo Clinic-Mayo Clinic College of Medicine-Mayo Medical School. The foundation for this program is strong research training in state-of-the-art biomedical techniques as applied to human-drug interactions. The Mayo Clinical Pharmacology training experience includes a curriculum that systematically exposes Trainees to critical aspects of the science that underlies Clinical Pharmacology. At the heart of the training is an outstanding individual research experience within a supportive mentoring environment. Clinical Pharmacology is a "bridge discipline" devoted to the study of the interaction between drugs and biological systems. However, within the context of the ongoing "revolution" that is occurring in biomedical science, a revolution that promises to transform medical practice, Clinical Pharmacology lies at the confluence of molecular pharmacology, genomics, proteomics, bioinformatics and rational therapeutics-with an ultimate goal of truly "individualized" drug therapy. Specifically, Clinical Pharmacology seeks to enhance our understanding of the molecular basis for drug response and the application of that information at the translational interface to make it possible to tailor drug therapy to both he underlying disease process and the unique characteristics of each individual patient. Our ability to take advantage of the opportunity represented by the dramatic advances that are occurring in biomedical science to achieve those goals will require that we train a new generation of Clinical Pharmacologists in "Systems Clinical Pharmacology". Large, comprehensive, integrated academic medical centers like the Mayo Clinic are ideally positioned to train this new generation of Clinical Pharmacologists. Mayo is able to do that because of its long history of the integration of basic and clinical medical research, because of a tradition of continuous contribution to the discipline of Clinical Pharmacology and because the Mayo Clinical Pharmacology Training Program has had decades of experience in successfully recruiting and training both physician scientists and laboratory-based translational scientists in Clinical Pharmacology. During the next funding cycle, the Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory-based research training in a supportive mentored environment joined with systematic exposure to developments in clinical science, with an emphasis on the rapidly evolving nature of biomedical science-all directed toward the goal of preparing each Fellow enrolled in the Program to become a future leader in Clinical Pharmacology.