Training Grant in Clinical Pharmacology

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ABSTRACT This proposal is a request for continued funding of the NIH-sponsored Clinical Pharmacology T32 Fellowship Training Program at the Mayo Clinic. The foundation for this long-running program is strong training in state-of-the-art biomedical research as applied to human-drug interactions, i.e., Clinical Pharmacology. The Mayo Clinical Pharmacology training experience includes a curriculum that exposes Trainees to the rapidly evolving science that underlies Clinical Pharmacology. However, beyond a strong curriculum that includes pharmacokinetics, drug metabolism and pharmacogenomics, at the heart of the Program are outstanding individual research experiences within a supportive mentoring environment. Clinical Pharmacology lies at the confluence of molecular pharmacology, multiple “omics” and, increasingly, exciting analytical techniques such as Artificial Intelligence and Machine Learning—techniques that this center has embraced and applied to studies of drug mechanisms and drug response. The union of these analytical techniques with the leadership that the Mayo Clinic Program has demonstrated over the years in the application of “multiple omics” to Clinical Pharmacology will help move us closer to the twin goals of truly “individualized” and “rational” drug therapy. We propose to take advantage of the opportunity represented by the dramatic advances occurring in biomedical and computational science to train the next generation of Clinical Pharmacologists by joining the latest laboratory-based pharmacologic science with modern computational techniques to enhance mechanistic understanding and the predictability of drug response. Comprehensive, highly integrated academic medical centers like the Mayo Clinic are ideally positioned to address this challenge. The Mayo Clinic has a history of performing and integrating outstanding basic and clinical medical research as well as a tradition of continuing contributions to the discipline of Clinical Pharmacology and decades of experience in recruiting and training both physician scientists and laboratory-based translational scientists in Clinical Pharmacology. During the next funding cycle, the Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory- based research training in a supportive mentored environment joined with a continually evolving curriculum and systematic exposure to advances in biomedical and computational science—all directed toward the goal of preparing each Fellow enrolled in the Program to become a future leader in Clinical Pharmacology in academia, in industry and in regulatory agencies.