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Alpha Synuclein, cellular dysfunction and Parkinson disease

Alpha Synuclein, cellular dysfunction and Parkinson disease
α 突触核蛋白、细胞功能障碍和帕金森病
批准号：
8736655
负责人：
Mark Cookson
金额：
$42.24万
依托单位：
NATIONAL INSTITUTE ON AGING
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8736655
关键词：
AcuteAddressBiological ModelsBrainCell LineCellsDementiaDepositionDiseaseFunctional disorderGenesGoalsIncidenceLaboratoriesLengthLewy BodiesMeasuresModelingMutationNeuronsPaperParkinson DiseaseProteinsPublicationsReportingStructureSystemTestingTimeToxic effectalpha synucleinprotein aggregationtau Proteins

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英文摘要
Several laboratories using different model systems have approached understanding why alpha-synuclein is toxic to cells. Our approach has been to develop a mammalian system where we can induce alpha-synuclein protein over several days with the long term goal of then finding genes that can block the effect. In parallel, we made cell lines expressing tau. Despite several previous publications supporting an acute toxic effect, we have fairly modest toxicity in our model. We are therefore addressing different strategies to recover modifiers. These include testing genes that are reported to worsen alpha-synuclein toxicity from previous papers, trying different measures of toxicity, and increasing the length of time for which toxic proteins are expressed.
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Alpha Synuclein, cellular dysfunction and Parkinson disease
  • 批准号：
    8552517
  • 项目类别：
  • 资助金额：
    $17.49万
  • 财政年份：
    --
  • 负责人：
    Mark Cookson
  • 依托单位：
    NATIONAL INSTITUTE ON AGING
Gene expression in the human brain
  • 批准号：
    8736661
  • 项目类别：
  • 资助金额：
    $25.35万
  • 财政年份：
    --
  • 负责人：
    Mark Cookson
  • 依托单位：
    NATIONAL INSTITUTE ON AGING
DJ-1 function and oxidative stress
  • 批准号：
    8552528
  • 项目类别：
  • 资助金额：
    $34.98万
  • 财政年份：
    --
  • 负责人：
    Mark Cookson
  • 依托单位：
    NATIONAL INSTITUTE ON AGING
Leucine rich repeat kinase 2 and dominantly inherited Parkinson disease
  • 批准号：
    8552524
  • 项目类别：
  • 资助金额：
    $64.96万
  • 财政年份：
    --
  • 负责人：
    Mark Cookson
  • 依托单位：
    NATIONAL INSTITUTE ON AGING
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