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Genetic Variants Associated with AD/ADRD

Genetic Variants Associated with AD/ADRD
与 AD/ADRD 相关的遗传变异
批准号：
10012630
负责人：
Mark Cookson
金额：
$12.98万
依托单位：
NATIONAL INSTITUTE ON AGING
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10012630
关键词：
AddressAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAutomationBiologyCell LineCellsClinicalDementiaDiseaseEventGenesGeneticGenetic DriftGenetic VariationGenomeHuman GeneticsInheritedLaboratoriesLinkage DisequilibriumMediatingMolecularMutationNeurodegenerative DisordersOncogenicOutputPopulation GeneticsRiskSamplingSourceSymptomsSystemTestingVariantgenetic risk factorgenetic variantgenome editinggenome wide association studyinduced pluripotent stem celllifetime risknon-genetictranscriptome sequencingtranscriptomicswhole genome

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中文摘要
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英文摘要
In this project, we plan to generate 200 new induced pluripotent stem cells (IPSCs) from donors whose whole genome sequence is already known. Due to the scale of this project, we have started to introduce laboratory automation in order to be able to handle and maintain a large number of cell lines. We have also identified donors from appropriate clinical sources and started to generate IPSC lines. We will test that the produced lines have the same genetic background as the original donors in the next few months to guard against sample mixups and genetic drift in the lines due to, for example, selection for cells that might have acquired oncogenic mutations.
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