Neuroeconomics of Framing Effects and Risk Attitudes in Early Dementia

早期痴呆症的框架效应和风险态度的神经经济学

• 批准号: 8581646
• 负责人: Winston Chiong
• 金额: $ 16.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8581646
• 关键词: Affect; Aging; Alzheimer' s Disease; Anterior; Attitude; Award; Behavior; Behavior Control; Behavioral; Biological Neural Networks; Brain; Brain imaging; California; Caregivers; Caring; Clinical; Cognitive; Data; Decision Making; Dementia; Development; Diagnostic; Disease; Early Diagnosis; Economic Models; Elderly; Emotional; Ethics; Family; Frontotemporal Dementia; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Health; Impairment; Insula of Reil; Intervention; Interview; Investigation; Judgment; Legal; Link; Measures; Mediating; Medical; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modeling; Neurologist; Neurology; Neurosciences; Outcome; Patients; Pattern; Policies; Predisposition; Prevention; Process; Public Health; Research; Rewards; Risk; Risk-Taking; Role; San Francisco; Source; Staging; Structure; Symptoms; Techniques; Training; Training Programs; Universities; Variant; Work; aging population; base; behavior measurement; career; cingulate cortex; executive function; experience; financial decision making; financial exploitation; improved; informant; insight; neuroeconomics; patient oriented research; prevent; programs; relating to nervous system; research study; response; tool; young adult

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Winston Chiong, a behavioral neurologist at the University of California, San Francisco. This K23 award will provide Dr. Chiong with the support necessary to accomplish the following goals: (1) to become expert at patient-oriented research in dementia; (2) to conduct behavioral and functional MRI investigations of decision-making in aging and in patients with Alzheimer's disease and frontotemporal dementia; (3) to characterize real-world decision-making errors in Alzheimer's disease and frontotemporal dementia using semi-structured informant interviews; (4) to apply tools and frameworks derived from neuroeconomics in interpreting patients' behaviors; (5) to apply new analytic techniques to functional MRI in dementia; and (6) to develop an independent research career. To achieve these goals, Dr. Chiong has assembled a mentoring team with two co-primary mentors. Dr. Howard Rosen is a behavioral neurologist who directs the UCSF State of California Alzheimer's Care Center and co-directs the UCSF Behavioral Neurology Training Program; and Dr. Mark D'Esposito is a behavioral neurologist and neuroscientist who directs the Henry H. Wheeler Jr. Brain Imaging Center at UC Berkeley. The mentoring team includes two collaborators: Dr. Joel Kramer, a neuropsychologist at UCSF with experience in measuring behavioral change in dementia; and Dr. Ming Hsu, a neuroeconomist at UC Berkeley with expertise in applying economic models to neural data. Finally, consultant Dr. John Neuhaus is a statistician who will assist in biostatistical analysis ad training. Financial decision-making errors can have disastrous consequences for patients and their families, and are among the earliest symptomatic indicators of dementia. Understanding the neural bases of these errors in dementia will therefore aid in early diagnosis, risk prediction harm prevention, and devising interventions to improve decision-making. Recent work in the neuroscience of decision-making provides a framework for understanding such errors in terms of decision-making biases, such as framing effects that distort financial judgment. Dr. Chiong's research will use a variety of techniques to study how decision-making biases and risk- taking are affected by aging and by Alzheimer's disease and frontotemporal dementia, two illnesses with very different effects on behavior and judgment. At a behavioral level, Dr. Chiong will use an established neuroeconomic task to assess framing effects and risk sensitivity in aging and in early disease. (Aim 1) At a neural level, he will use functional MRI to assess how large-scale neural network perturbations in these diseases affect financial decision-making. (Aim 2) And at a clinical level, he will use informant interviews within a neuroeconomic framework to characterize the financial decision-making errors that patients make in the real world. (Aim 3) These studies will advance our understanding of this important early symptom in dementia, setting the stage for future investigations of its significance in early diagnosis, and for behavioal and policy interventions to improve decision-making.

描述(申请人提供)：这是为加州大学旧金山分校的行为神经学家Winston Chiong博士申请K23奖项。这一K23奖项将为钟博士提供必要的支持，以实现以下目标：(1)成为以患者为中心的痴呆症研究专家；(2)对老年以及阿尔茨海默病和额颞痴呆患者的决策进行行为和功能磁共振调查；(3)通过半结构化信息者访谈来表征阿尔茨海默病和额颞痴呆症的真实世界决策错误；(4)应用神经经济学的工具和框架来解释患者的行为；(5)将新的分析技术应用于痴呆症的功能磁共振；(6)发展独立的研究事业。为了实现这些目标，琼博士组建了一个由两名共同小学导师组成的辅导团队。霍华德·罗森博士是行为神经学家，他是加州大学旧金山分校阿尔茨海默氏症护理中心的负责人，也是加州大学旧金山分校行为神经学培训项目的联合负责人；马克·德斯波西托博士是行为神经学家和神经学家，他是小亨利·H·惠勒项目的负责人。加州大学伯克利分校的脑成像中心。指导团队包括两名合作者：加州大学旧金山分校的神经心理学家乔尔·克莱默博士，他在测量痴呆症的行为变化方面有经验；以及加州大学伯克利分校的神经经济学家徐明博士，他擅长将经济模型应用于神经数据。最后，顾问John Neuhaus博士是一名统计学家，他将协助生物统计分析和培训。财务决策失误可能会给患者及其家人带来灾难性的后果，是痴呆症的最早症状指标之一。因此，了解痴呆症中这些错误的神经基础将有助于早期诊断、风险预测、伤害预防和设计干预措施以改善决策。最近在决策神经科学方面的研究为从决策偏差的角度理解此类错误提供了一个框架，例如扭曲财务判断的框定效应。琼博士的研究将使用多种技术来研究年龄、阿尔茨海默病和额颞痴呆对决策偏差和冒险行为的影响，这两种疾病对行为和判断力的影响截然不同。在行为层面上，琼博士将使用一项既定的神经经济学任务来评估在衰老和早期疾病中的框架效应和风险敏感性。(目标1)在神经层面，他将使用功能磁共振来评估这些疾病中的大规模神经网络扰动如何影响金融决策。(目标2)在临床层面，他将在神经经济学框架内使用线人访谈来描述患者在现实世界中犯下的财务决策错误。(目的3)这些研究将促进我们对痴呆症这一重要早期症状的了解，为今后研究其在早期诊断中的意义以及为改善决策的行为和政策干预奠定基础。