Predoctoral Training in Exercise Physiology and Aging

运动生理学和衰老的博士前培训

• 批准号: 8448214
• 负责人: JAMES M HAGBERG
• 金额: $ 16.55万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448214
• 关键词: Aging; Exercise Physiology; Training; pre-doctoral

The University of Maryland College Park Department of Kinesiology exercise biology and aging program has a history of producing well-trained PhDs who complete postdoctoral training and become productive faculty members. We have supported 18 trainees over the first 9 yrs of this program with 12 completing their PhD degrees, 5 still in training, and 1 pursuing an MD/PhD degree in a different discipline (neuroscience). Eleven of the 12 who graduated (92%) have gone on to NIH postdoctoral research fellowships. Seven of these 12 graduates are now in tenure-track academic positions, 1 is in industry, 1 is part-time faculty, and 3 are still in postdoctoral positions. Furthermore, we have graduated 3 African-American women who have gone on to NIH postdoctoral research fellowships at UT-Southwestern, Wake Forest, and Temple. This program provides trainees with the skills necessary for them to complete high-quality dissertation research projects addressing: 1) age-related changes in body composition, metabolic, CV, and musculoskeletal function, and CV disease risk factors; 2) exercise training-induced changes in these same parameters; 3) the genetic architecture underlying the baseline measures of these parameters, their changes with aging, and their changes with exercise training interventions; and 4) the mechanisms responsible for these responses in animal and cell culture models using cell and molecular biology methodologies. A substantial enhancement of this renewal Training Program is this translational component, whereby trainees can extend their studies from human physiological studies to investigations in animal models and cell culture to delineate the underlying cell and molecular mechanisms. Trainees' research can be conducted with Primary, Secondary, and Associate Mentors at closely collaborating laboratories at the University of Maryland School of Medicine Division of Gerontology, Division of Endocrinology, Diabetes, and Nutrition, Department of Physiology, and School of Nursing and Childrens National Medical Center Research Center for Genetic Medicine. Trainees complete coursework in the basic biology of aging; specific knowledge in exercise, CV, musculoskeletal, metabolic, cell, and molecular biology and physiology; genetics; and biostatistics and research design. We propose to continue this program to fund each of 6 predoctoral trainees for 4 yrs to complete their PhD degrees with high-quality coursework and a dissertation research project that will prepare them for an NIH postdoctoral research fellowship and an eventual academic faculty position with a research program focusing on exercise biology and aging. RELEVANCE (Seeinstructions): This program will support 6 trainees/yr to complete their PhD degrees with a high-quality dissertation research project. The long-term goal is to prepare trainees to pursue high-level NIH postdoctoralresearch fellowships and, eventually, academic faculty positions that focus on research and teaching in the prevention of such major age-associated issues as sarcopenia, obesity, diabetes, hypertension, and CV disease.

马里兰大学帕克分校运动机能学系运动生物学和衰老项目 培养训练有素的博士的历史，这些博士完成了博士后培训并成为富有成效的教师 成员。在该计划的前 9 年里，我们为 18 名学员提供了支持，其中 12 人完成了博士学位 学位，5 名仍在接受培训，1 名正在攻读不同学科（神经科学）的医学博士/博士学位。十一 12 名毕业生中的 92%（92%）继续获得 NIH 博士后研究奖学金。这12个中的7个 毕业生目前担任终身教职，1 人在工业界，1 人为兼职教师，3 人仍在工业界 博士后职位。此外，我们还毕业了 3 名非裔美国女性，她们继续深造 美国国立卫生研究院 (NIH) 德克萨斯大学西南分校、维克森林大学和坦普尔大学的博士后研究奖学金。这个节目 为学员提供完成高质量论文研究项目所需的技能 解决：1) 与年龄相关的身体成分、代谢、心血管和肌肉骨骼功能的变化，以及 心血管疾病危险因素； 2) 运动训练引起的这些相同参数的变化； 3）遗传 这些参数的基线测量、它们随老化的变化及其变化的基础架构 运动训练干预措施的变化； 4) 负责这些响应的机制 使用细胞和分子生物学方法的动物和细胞培养模型。实质性增强 这个更新培训计划的一部分是转化部分，学员可以借此扩展他们的学习 从人类生理研究到动物模型和细胞培养的研究，以描绘 潜在的细胞和分子机制。学员的研究可以在小学、中学、 马里兰大学医学院密切合作实验室的副导师 老年学科、内分泌、糖尿病和营养学科、生理学系和 护理学院和儿童国家医学中心遗传医学研究中心。实习生 完成衰老基础生物学课程；运动、CV、肌肉骨骼方面的具体知识， 代谢、细胞和分子生物学和生理学；遗传学；以及生物统计学和研究设计。我们 建议继续该计划，资助 6 名博士前培训生每人 4 年完成博士学位 具有高质量课程和论文研究项目的学位，将为他们进入 NIH 做好准备 博士后研究奖学金和最终的学术教职职位以及研究项目 专注于运动生物学和衰老。 相关性（参见说明）： 该计划每年将支持 6 名学员完成博士学位并撰写高质量论文 研究项目。长期目标是培养学员从事高水平的 NIH 博士后研究 奖学金，并最终获得专注于预防研究和教学的学术教职职位 肌肉减少症、肥胖、糖尿病、高血压和心血管疾病等与年龄相关的主要问题。