Investigating the role of novel heterochromatin and centromere proteins in chromosome segregation

研究新型异染色质和着丝粒蛋白在染色体分离中的作用

• 批准号: nhmrc : 1012470
• 负责人: Dr Danielle Irvine
• 金额: $ 34.87万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-novel-chromosome-segregation/109663
• 关键词: Investigating; role; novel; heterochromatin; centromere

The equal division of genetic material during cell division is essential so that genetic material is not lost or gained. This process is controlled by a complex array of proteins that replicate the genome, maintain its structural integrity, and equally distribute one copy to each daughter cell. This research aims to study the functions of newly identified proteins required for this process in a single cell yeast model-system and in human and mouse cells.

在细胞分裂过程中，遗传物质的平等分裂是必不可少的，这样遗传物质才不会丢失或获得。这一过程由一系列复杂的蛋白质控制，这些蛋白质复制基因组，保持其结构完整性，并平等地将一个副本分配给每个子细胞。这项研究的目的是在单细胞酵母模型系统中以及在人和小鼠细胞中研究新发现的蛋白质在这一过程中所需的功能。