UMASS Small Animal Imaging Core Renovation

项目摘要/摘要-美国马萨诸塞州小动物成像核心改造 马萨诸塞大学医学院(UMMS)正在申请资金进行搬迁和翻新 为其目前的小动物成像核心(SAIC)提供空间。目前的上汽集团是 学校的研究努力，但它位于一个普通流通走廊上的一个313英尺2的房间里，在 动物设施。目前SAIC的大小和位置阻碍了纵向(重复)成像研究 并阻止了UMMS为重要的传染病研究进行ABSL-2成像。这个 上汽拥有一台SPECT/CT、PET、Maestro EX和一台Li-Cor近红外成像仪。后者被放在手推车上 并在需要时与上海汽车工业集团公司一起转移到一个可行的地点。由于上汽集团内部空间不足， IVIS 100光学成像仪与Maestro ex光学成像仪放在动物设施内的一个小房间里 成像仪。此外，目前的国家工商总局没有单独的放射性核素制备和储存空间；有 动物准备空间不足，没有扩张的空间。拥有迅速增长的教职员工和国家 对优秀研究的表彰扩展分子成像计划是必要的，以支持 学校正在进行的和未来的研究计划。 UMMS建议通过将上汽集团重新定位和改造为1553网ft2来弥补这些不足 在其A级动物设施内的区域。A-Level动物设施是学校唯一拥有ABSL的动物设施- 2和ABSL-3动物舍。尽管老鼠房的空间很贵，而且拟议的空间将 取代老鼠，阿尔伯特·谢尔曼中心，一座新开放的研究和教学楼，有足够的 为流离失所的动物提供动物住所的空间。 具体目标是，并将通过以下方式实现：1)将上汽集团从 A级动物设施内的一个地点的行人交通。2)提供足够的空间来容纳 所有现有的成像设备，并有毗连的空间，以供未来扩展。3)提供充足的 动物准备、放射性同位素准备和储存以及ABSL-1和ABSL-2动物收容所的空间。 这将允许在单项和纵向研究中进行ABSL-2成像。4)提供有限数量的 实施目标1-3所需的设备。 如果获得资金，上汽集团的搬迁和改造将支持正在进行的重要研究 UMMS，包括先进治疗集群、基因治疗中心、RNA治疗 布鲁尼克神经精神病学研究所，干细胞生物学和再生医学中心， 癌症中心、艾滋病研究中心、比较神经成像中心、传染病中心 疾病和疫苗研究、糖尿病和内分泌研究中心(DERC)，药物研究所 抗性，以及基因功能与表达程序。

Project Summary/Abstract - UMass Small Animal Imaging Core Renovation The University of Massachusetts Medical School (UMMS) is applying for funds to relocate and renovate space for its current Small Animal Imaging Core (SAIC). The current SAIC is an important component of the school's research efforts but it is located in a single 313 ft2 room on a general circulation corridor, outside of the animal facility. The size and location of the current SAIC hinders longitudinal (repeated) imaging studies and has prevented UMMS from performing ABSL-2 imaging for important infectious disease research. The SAIC houses a SPECT/CT, PET, Maestro EX and a Li-Cor near infrared imager. The latter is kept on a cart and moved to a workable location with the SAIC when needed. Because of a lack of space within the SAIC an IVIS 100 optical imager is kept in a small room within the animal facility along with the Maestro EX optical imager. Additionally, the current SAIC has no separate room for radionuclide preparation and storage; there is inadequate animal preparation space, and no space for expansion. With a rapidly growing faculty and national recognition for research excellence an expanded molecular imaging program is necessary to support the school's ongoing and future research programs. UMMS proposes to remedy these deficiencies by relocating and renovating the SAIC to a 1553 net ft2 area within its A-Level animal facility. The A-Level animal facility is the school's only animal facility with ABSL- 2 and ABSL-3 animal housing. Although mouse housing space is at a premium and the proposed space will displace mice, the Albert Sherman Center, a newly opened research and teaching building, has adequate animal housing space for the displaced animals. The Specific Aims are, and will be accomplished by: 1) Relocating the SAIC away from general pedestrian traffic to a location within the A-Level animal facility. 2) Providing sufficient space to accommodate all the current imaging equipment and having contiguous space for future expansion. 3) Providing adequate space for animal preparation, radioisotope preparation and storage and ABSL-1 and ABSL-2 animal housing. This will allow for ABSL-2 imaging in single and longitudinal studies. 4) Provide for a limited amount of equipment needed to implement Aims 1-3. This relocation and renovation of the SAIC, if funded, will support important ongoing research at UMMS, including those of the Advanced Therapeutics Cluster, Gene Therapy Center, RNA Therapeutics Institute, Center for Stem Cell Biology & Regenerative Medicine, Brudnick Neuropsychiatric Research Institute, Cancer Center, Center for AIDS Research, Center for Comparative Neuroimaging, Center for Infectious Diseases & Vaccine Research, Diabetes & Endocrinology Research Center (DERC), Institute for Drug Resistance, and the Program in Gene Function & Expression.