Advancing Neuroscience Research by Modernizing Animal Housing to Improve Animal Well-Being and Science
通过现代化动物饲养来促进神经科学研究,以改善动物福祉和科学
基本信息
- 批准号:10735300
- 负责人:
- 金额:$ 23.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-15 至 2024-06-14
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ExperimentationAnimal HousingAnimal WelfareAnimalsBehavioralCaringCensusesChicagoDataElectricityEnvironmentEnvironmental ImpactEnvironmental MonitoringFacultyFundingFutureGrowthHealthHomeHousingHumanIndividualInstitutionLaboratoriesLaboratory Animal MedicineLaboratory Animal Production and FacilitiesLaboratory Animal ScienceLaboratory AnimalsMacacaMacaca mulattaMental HealthMethodsMissionModernizationMonkeysMovementMusNeurosciencesNeurosciences ResearchOccupational HealthOperations ResearchOutcomeOutcome StudyOutcomes ResearchPersonal SatisfactionPlayPrimatesProceduresRecording of previous eventsReproducibilityResearchResearch SupportRodentScheduleScienceSentinelSideSteamSurveillance ProgramSystemTechniquesTrainingUniversitiesUpdateVeterinariansWaterWell in selfWorkanimal careanimal facilityanimal resourcedesignenvironmental enrichment for laboratory animalsfaculty supportimprovedinnovationinterestnonhuman primateoperationphysical conditioningprogramsrecruitresearch studyrestraintsocialsocial groupspecies typical behavior
项目摘要
Project Abstract
The University of Chicago has a robust and growing neuroscience program. Central to these research studies
are non-human primates trained to perform behavioral tasks as part of the research. Training of these behavioral
tasks takes months to years to complete and successful outcomes require animals to be in their best physical
and psychological health. Assuring animals are kept in excellent health is a shared mission of the Animal
Resources Center and the neuroscience laboratories. We approach animal care collaboratively to look for ways
to improve animal welfare and research outcomes. This strategy has allowed the Animal Resources Center to
make numerous improvements in the care and use of animals at the institution. We propose to outfit newly
renovated rooms with a new multi-animal housing system which will increase the size and quality of space
available to the animals, enhance their ability to express species-typical behaviors in an enriched environment
and improve their social housing opportunities. With these new enclosures, we will be better able to approximate
a natural environment for the animals, which in turn makes them better suited for research of human conditions
and contributes to enhanced reproducibility and the integrity of the science. We anticipate with this positive
change, health problems will potentially be decreased due to improvement in enrichment opportunities and social
housing. These enclosures also will streamline operations by creating larger social groups with abundant
enrichment space, which will eliminate the need to move enrichment play cages between rooms, and will
eliminate the need to move and transport cages between animal rooms and cage wash. This will decrease labor
associated with cage changing and cage washing. An environmental impact, through the reduced use of cage
wash water, steam, and electricity is also expected. The new housing system will also increase our capacity for
maintaining additional primates in the same room by allowing more animals to be housed in the enclosures than
possible with standard caging systems. The most enthusiastic aspect of this proposal, however, is the ability to
initiate cage side research studies within these enclosures. Cage side studies allow the monkey to conduct their
work in their home cage voluntarily without the need for transport to the laboratory, thus also eliminating the
need for techniques for water access scheduling in some animals. This will streamline research operations in
addition to the husbandry efficiencies already mentioned. The transition to a new housing system will, therefore,
not only provide an environment that promotes improved animal health and psychological well-being, and
streamline husbandry operations, but will also positively impact research outcomes and improve scientific
operations by pioneering a new method to collect research data with the animals.
项目摘要
芝加哥大学有一个强大的和不断增长的神经科学计划。这些研究的核心是
作为研究的一部分,非人类灵长类动物被训练来执行行为任务。训练这些行为
任务需要几个月到几年的时间才能完成,成功的结果需要动物处于最佳的身体状态,
和心理健康。确保动物保持良好的健康是动物的共同使命
资源中心和神经科学实验室我们合作对待动物,
改善动物福利和研究成果。这一战略使动物资源中心能够
在该机构对动物的护理和使用方面做出许多改进。我们建议重新装备
翻新的客房采用新的多动物饲养系统,增加了空间的大小和质量
增强它们在丰富的环境中表达物种典型行为的能力
并改善他们的社会住房机会。有了这些新的外壳,我们将能够更好地近似
动物的自然环境,这反过来又使它们更适合人类条件的研究
并有助于提高科学的可重复性和完整性。我们期待着这一积极的
改变,健康问题将有可能减少,由于丰富的机会和社会的改善,
住房这些圈地还将通过创建更大的社会群体来简化运营,
丰富的空间,这将消除需要移动丰富发挥笼子之间的房间,
消除了在动物房和笼清洗之间移动和运输笼的需要。这将减少劳动力
与换笼和洗笼有关。通过减少笼的使用,对环境产生影响
还需要洗涤水、蒸汽和电力。新的住房制度也将提高我们的能力,
通过允许更多的动物被安置在围栏中,
可能与标准笼系统。然而,这项提议最令人兴奋的方面是,
在这些围栏内启动笼边研究。笼边研究允许猴子进行他们的
自愿在其家笼中工作,而不需要运送到实验室,从而也消除了
需要一些动物的水访问调度技术。这将简化研究业务,
除了已经提到的饲养效率之外。因此,向新住房制度的过渡将,
不仅提供一个促进改善动物健康和心理健康的环境,
简化畜牧业运作,但也将积极影响研究成果,并提高科学
通过开创一种新的方法来收集动物的研究数据。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
George Parsons Langan其他文献
George Parsons Langan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('George Parsons Langan', 18)}}的其他基金
Facility Management, Maintenance and Operations Core
设施管理、维护和运营核心
- 批准号:
10793949 - 财政年份:2023
- 资助金额:
$ 23.4万 - 项目类别:
Facility Modernization and Programmatic Expansion of the University of Chicago Gnotobiotic Research Animal Facility
芝加哥大学知生研究动物设施的设施现代化和规划扩建
- 批准号:
10597327 - 财政年份:2022
- 资助金额:
$ 23.4万 - 项目类别:
Functional and Efficiency Upgrades for the Carlson Cage Wash Facility
卡尔森笼式清洗设施的功能和效率升级
- 批准号:
8710955 - 财政年份:2014
- 资助金额:
$ 23.4万 - 项目类别:
相似海外基金
Development of a Drosophila-based platform to replace and reduce animal experimentation in epilepsy research
开发基于果蝇的平台来取代和减少癫痫研究中的动物实验
- 批准号:
NC/V001051/1 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Ethical Issues in Animal Experimentation
博士论文研究:动物实验的伦理问题
- 批准号:
1424484 - 财政年份:2014
- 资助金额:
$ 23.4万 - 项目类别:
Standard Grant
Tissue formation involving stem/progenitor cell research and animal experimentation (N01)
涉及干/祖细胞研究和动物实验的组织形成(N01)
- 批准号:
30245585 - 财政年份:2006
- 资助金额:
$ 23.4万 - 项目类别:
Collaborative Research Centres
Animal experimentation and cardiac phenotyping of transgenic mouse models
转基因小鼠模型的动物实验和心脏表型分析
- 批准号:
13327687 - 财政年份:2005
- 资助金额:
$ 23.4万 - 项目类别:
Research Units
Animal Experimentation system as an infrastructure to support translational progression of diabetes research to medical practice
动物实验系统作为支持糖尿病研究向医学实践转化的基础设施
- 批准号:
17200029 - 财政年份:2005
- 资助金额:
$ 23.4万 - 项目类别:
Grant-in-Aid for Scientific Research (A)