Structural and functional studies of M. tuberculosis type VII secretion

Oren Rosenberg博士是一位具有结构生物学背景的传染病医生。他在这个当前项目中的目标是通过研究结核分枝杆菌（Mtb）（结核病的病原体）中关键毒力决定簇的结构和功能，将他的临床和基础科学兴趣联合收割机结合起来。通过一系列使用结构，生化和遗传方法相结合的具体目标，Rosenberg博士将研究VII型分泌系统中基本成分的作用，该系统已知对Mtb的毒力至关重要。目的是更好地了解分枝杆菌感染，以帮助设计更快，更便宜，毒性更小和更有效的方法来预防和治疗结核病。此外，该提案旨在补充Rosenberg博士先前的实验室经验，并为他提供微生物发病机理和结构生物学方面的必要技术和知识背景，以作为独立研究者。一个由医生和科学家组成的委员会将监督罗森博格博士走向独立的进程。他的科学发展也将通过参加UCSF课程的相关主题，几个系列研讨会，部门务虚会和国家会议丰富。罗森伯格博士将通过在旧金山弗朗西斯科总医院结核病诊所的工作，发展结核病和其他呼吸道感染的临床专业。在授予期结束时，Rosenberg博士将准备作为微生物发病机理基础生物学的独立研究者开发自己的研究和临床议程。

Dr. Oren Rosenberg is an infectious disease physician with a background in structural biology. His objective in this current project is to combine his clinical and basic science interests by studying the structure and function of key virulence determinants in Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Through a series of specific aims that use a combined structural, biochemical and genetic approach, Dr. Rosenberg will examine the role of essential components in the type VII secretion system, which is known to be critical for the virulence of Mtb. The goal is to understand mycobacterial infection better so as to aid in the design of faster, cheaper, less toxic and more effective ways to prevent and treat tuberculosis. Additionally this proposal is designed to complement Dr. Rosenberg's prior laboratory experience and provide him with the requisite technical and intellectual background in microbial pathogenesis and structural biology to function as an independent investigator. A committee of physicians and scientists will oversee Dr. Rosenberg's progression towards independence. His scientific development will also be enriched through attendance at UCSF courses in pertinent topics, several seminar series, departmental retreats and national meetings. Dr. Rosenberg will develop a clinical specialization in tuberculosis and other respiratory infections through work at the tuberculosis clinic at San Francisco General Hospital. At the end of the granting period Dr. Rosenberg will be prepared to develop his own research and clinical agenda as an independent investigator in the basic biology of microbial pathogenesis.