Maintenance of Ideal Cardiovascular Health across the Life Course in Women

维持女性整个生命过程中理想的心血管健康

• 批准号: 8821698
• 负责人: Holly Catherine Gooding
• 金额: $ 13.71万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8821698
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; American; Area; Atherosclerosis; Awareness; Behavior; Behavior Therapy; Behavioral; Biological Preservation; Blood Pressure; Boston; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Child; Childhood; Cholesterol; Chronic Disease; Clinical; Cognitive; Cohort Analysis; Cohort Studies; Communication Research; Coronary artery; Coupled; Data; Data Analyses; Deterioration; Development; Diabetes Mellitus; Education; Environment; Epidemiologic Studies; Epidemiology; Ethnic group; Female; Female Adolescents; Focus Groups; Future; Glucose; Goals; Growth; Guidelines; Health; Health Care Costs; Health Communication; Health Promotion; Individual; Intervention; K-Series Research Career Programs; Lead; Life; Life Cycle Stages; Life Expectancy; Longevity; Longitudinal Studies; Maintenance; Measures; Mentors; Mentorship; Methodology; Methods; Modeling; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Patients; Pattern; Pediatric Hospitals; Physiological; Predisposition; Probability; Psychological Factors; Public Health Practice; Public Health Schools; Qualitative Methods; Qualitative Research; Race; Relative (related person); Research; Research Personnel; Research Training; Risk; Schools; Staging; Statistical Methods; Techniques; Testing; Training; Training Activity; Translating; United States; Vulnerable Populations; Woman; Writing; Youth; biopsychosocial; cardiovascular disorder epidemiology; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; career; career development; catalyst; cohort; design; early adolescence; early childhood; effective intervention; experience; girls; innovation; meetings; middle age; mortality; non-invasive imaging; novel; novel strategies; patient oriented; patient oriented research; predictive modeling; primary outcome; public health relevance; racial and ethnic; secondary outcome; young adult; young woman

 DESCRIPTION (provided by applicant): This patient-oriented K23 Career Development Award will provide the candidate with the training and research experience essential to launch an independent research career focused on the early prevention of cardiovascular disease in girls and women. Recent research has identified substantially lower cardiovascular morbidity and mortality in those women able to reach middle age with a constellation of physiologic and behavioral factors known as ideal cardiovascular health. However, little is known about earlier factors that are particularly salient for the maintenance of ideal cardiovascular health into adulthood in general or in women specifically. By using a novel technique of creating sequential risk prediction models in two epidemiologic cohorts with overlapping age ranges, the candidate will quantify the relative importance of cardiovascular health-promoting behavioral, physiologic, and psychological factors during the critical life stages of adolescence and early young adulthood. [The candidate will conduct qualitative studies to identify developmentally appropriate strategies for promotion of behaviors identified in the two cohort studies. The candidate will then be poised to write an R01 application focused on developing and evaluating targeted behavioral interventions for promoting ideal health among adolescent and young adult women from a variety of racial/ethnic backgrounds.] The training plan will support all aspects of the research strategy and uniquely prepare the candidate for an independent research career using longitudinal cohort analyses and qualitative research strategies to inform cutting edge patient-oriented behavioral interventions. The coursework, mentorship team, and research experiences are designed to provide synergistic training in 1) life course and chronic disease epidemiology, 2) statistical methods for studying critical windows in the life course, and 3) [patient-oriented health communications research that informs the design of developmentally appropriate behavioral interventions]. The Harvard School of Public Health, Harvard Graduate School of Education, Harvard Catalyst, and Boston Children's Hospital all offer unparalleled environments in these three areas. The candidate has assembled a mentorship team with expertise in cardiovascular epidemiology, child and adolescent health, longitudinal cohort analysis, focus group methodology, qualitative data analysis, and health communication and health promotion with vulnerable populations. Mentored by this team the candidate will be well-suited to achieve her immediate career goals of furthering her training in patient-oriented research and cardiovascular epidemiology, identifying critical windows in the lives of young women for cardiovascular health maintenance, and translating these findings to cardiovascular health promoting strategies in youth. [Training activities and results will inform submission of R01 proposals to conduct trials of behavioral interventions aimed at the unique needs of adolescent girls and young women and to conduct epidemiologic studies of cardiovascular health promoting factors in early childhood and the peri-natal period.] Ultimately the candidate's goals are to deepen the understanding of factors related to the maintenance of cardiovascular health throughout the life course and to design novel and effective interventions that enhance positive factors and counterbalance negative factors related to cardiovascular disease risk.

 描述（由申请人提供）：这个以患者为导向的K23职业发展奖将为候选人提供必要的培训和研究经验，以开展独立的研究职业生涯，重点是女孩和妇女心血管疾病的早期预防。最近的研究发现，在那些能够达到中年的妇女中，心血管疾病的发病率和死亡率大大降低，这些妇女具有一系列被称为理想心血管健康的生理和行为因素。然而，人们对早期因素知之甚少，这些因素对于维持理想的心血管健康到成年期尤其重要，特别是在女性中。通过使用一种新的技术，在两个年龄范围重叠的流行病学队列中创建顺序风险预测模型，候选人将量化在青春期和成年早期的关键生命阶段期间促进心血管健康的行为，生理和心理因素的相对重要性。[The候选人将进行定性研究，以确定发展适当的战略，促进在两个队列研究中确定的行为。然后，候选人将准备写一个R 01应用程序，重点是开发和评估有针对性的行为干预措施，以促进来自各种种族/民族背景的青少年和年轻成年女性的理想健康。培训计划将支持研究策略的各个方面，并使用纵向队列分析和定性研究策略为候选人的独立研究生涯做好独特的准备，以告知最前沿的以患者为导向的行为干预措施。课程，导师团队和研究经验的目的是提供协同培训1）生命历程和慢性病流行病学，2）研究生命历程中的关键窗口的统计方法，和3）[以患者为导向的健康传播研究，告知发展适当的行为干预措施的设计]。哈佛公共卫生学院、哈佛教育研究生院、哈佛催化剂学院和波士顿儿童医院都在这三个领域提供了无与伦比的环境。候选人组建了一个导师团队，拥有心血管流行病学，儿童和青少年健康，纵向队列分析，焦点小组方法，定性数据分析以及与弱势群体的健康传播和健康促进方面的专业知识。在这个团队的指导下，候选人将非常适合实现她的直接职业目标，即进一步培训以患者为导向的研究和心血管流行病学，确定年轻女性生活中的关键窗口心血管健康维护，并将这些发现转化为青年心血管健康促进策略。[培训活动和结果将为提交R 01提案提供信息，以针对少女和年轻妇女的独特需求进行行为干预试验，并对幼儿和围产期心血管健康促进因素进行流行病学研究。最终，候选人的目标是加深对整个生命过程中心血管健康维护相关因素的理解，并设计新颖有效的干预措施，增强积极因素，抵消与心血管疾病风险相关的消极因素。