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Vasopressin and Maternal Behavior

加压素和母亲行为

基本信息

批准号：
8601537
负责人：
BENJAMIN C NEPHEW
金额：
$ 24.2万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8601537
关键词：
Acute Adrenal Cortex Hormones Affect Aggressive behavior Anxiety Argipressin Autoradiography Behavior Behavior Control Behavior Disorders Behavioral Brain region Child Child health care Chronic Chronic stress Computer Retrieval of Information on Scientific Projects Database Data Databases Development Disease Drops Endocrine Ensure Etiology Exposure to Female Focus Groups Functional Magnetic Resonance Imaging Goals Health Health behavior Hormones Human Image In Situ Hybridization Investigation Lactation Link Maternal Behavior Mediating Mental Depression Messenger RNA Methods Mission Molecular Mood Disorders Mothers National Institute of Child Health and Human Development Neurohormones Neurosciences Neurosecretory Systems Operative Surgical Procedures Oxytocin Oxytocin Receptor Peptides Peripheral Personal Satisfaction Persons Physiological Physiology Postpartum Depression Postpartum Period Productivity Protocols documentation Rattus Rehabilitation therapy Reporting Reproductive Process Research Risk Factors Role Stress Structure System Techniques Testing Training United States National Institutes of Health Vasopressins Woman acute stress base career disability indexing mRNA Differential Displays mRNA Expression maternal aggression molecular imaging offspring parity pup relating to nervous system release factor research study response social social stress stressor

项目摘要

The mission ofthe NICHD is to ensure that every person is born healthy and wanted, that women suffer no harmful effects from reproductive processes, and that ail children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation. Postpartum anxiety and depression-associated disorders can have negative effects on the health of both mother and offspring through effects on matemal behavior, and little is known about the etiology of these disorders. Although chronic stress is a significant risk factor for depression, it is unknown how chronic stress during lactation affects maternal behavior. Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior in lactating rats. It is hypothesized that the central AVP system may be a potential target for the treatment of postpartum behavioral disorders, as central manipulations of AVP alter behavior. The overall objective of the current protocol is to investigate the role of AVP in postpartum maternal behavior and aggression, and the effects of social stress on this system. The specific aims ofthe current proposal are to characterize the roles of central AVP, OXT, and CRH in the control of maternal behavior and maternal aggression, investigate the effects of chronic social stressors on these behaviors and central AVP, and investigate a potential AVP-mediated mechanism forthe effects of chronic social stress on maternal behavior. These aims will be pursued using behavioral, endocrine, physiological and molecular methods to quantify the effects of chronic social stressors, molecular and imaging (fMRI) techniques to identify the neural regions implicated in the acute and chronic control of maternal behavior, and stereotaxic surgical techniques to manipulate central AVP activity. The overal goal is to gain valuable training in behavioral) neuroscience techniques and study the neuropeptidergic control of behavior. The long term career goal is to develop new targets and treatments for behavioral disorders of mothers.

NICHD的使命是确保每个人出生时都是健康的，是需要的，妇女不遭受任何痛苦，生殖过程的有害影响，所有儿童都有机会充分实现其健康和有生产力的生活的潜力，没有疾病或残疾，并确保健康，通过最佳康复，提高所有人的生产力、独立性和福祉。产后焦虑抑郁症相关疾病会对母亲和后代的健康产生负面影响通过对母亲行为的影响，对这些疾病的病因知之甚少。虽然慢性压力是抑郁症的一个重要危险因素，目前尚不清楚哺乳期间的慢性压力如何影响抑郁症。影响母性行为最近的分子研究表明，神经激素精氨酸加压素 (AVP)催产素（OXT）和皮质类固醇释放激素（CRH）可能参与调节哺乳期大鼠的母性行为。推测中枢AVP系统可能是潜在的靶点用于治疗产后行为障碍，因为AVP的中枢操作改变行为。的本方案的总体目标是研究AVP在产后母亲行为中的作用，攻击，以及社会压力对这个系统的影响。目前提案的具体目标是描述中枢AVP、OXT和CRH在控制母体行为和母体发育中的作用。攻击，研究慢性社会压力对这些行为和中枢AVP的影响，探讨AVP介导的慢性社会应激对孕产妇的影响机制，行为这些目标将采用行为、内分泌、生理和分子方法来实现，量化慢性社会压力的影响，分子和成像（fMRI）技术，以确定神经区域牵连在急性和慢性控制产妇的行为，和立体定位手术操纵中枢AVP活性的技术。总体目标是获得有价值的行为训练）神经科学技术和研究行为的神经肽能控制。长期职业目标是为母亲的行为障碍开发新的目标和治疗方法。