Central Vasopressin and Maternal Behavior

中枢加压素和母亲行为

• 批准号: 7739025
• 负责人: BENJAMIN C NEPHEW
• 金额: $ 8.84万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7739025
• 关键词: Acute; Adrenal Cortex Hormones; Affect; Aggressive behavior; Anxiety; Argipressin; Autoradiography; Behavior; Behavior Control; Behavior Disorders; Behavioral; Brain region; Child; Child health care; Chronic; Chronic stress; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Development; Disease; Drops; Endocrine; Ensure; Etiology; Exposure to; Female; Focus Groups; Functional Magnetic Resonance Imaging; Goals; Health; Health behavior; Hormones; Human; Image; In Situ Hybridization; Instruction; Investigation; Lactation; Life; Link; Maternal Behavior; Mediating; Messenger RNA; Methods; Mission; Molecular; Mood Disorders; Mothers; National Institute of Child Health and Human Development; Neurohormones; Neurosciences; Neurosecretory Systems; Operative Surgical Procedures; Oxytocin; Oxytocin Receptor; Peptides; Peripheral; Personal Satisfaction; Persons; Physiological; Physiology; Postpartum Depression; Postpartum Period; Productivity; Protocols documentation; Rattus; Rehabilitation therapy; Reporting; Reproductive Process; Research; Research Personnel; Risk Factors; Role; Stress; System; Techniques; Testing; Training; United States National Institutes of Health; Vasopressins; Woman; acute stress; base; career; depression; disability; indexing; mRNA Differential Displays; mRNA Expression; maternal aggression; molecular imaging; offspring; parity; programs; public health relevance; pup; relating to nervous system; response; social; social stress; stressor

DESCRIPTION (provided by applicant): The mission of the NICHD is to ensure that every person is bom healthy and wanted, that women suffer no harmful effects from reproductive processes, and that all children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation. Postpartum anxiety and depression- associated disorders can have negative effects on the health of both mother and offspring through effects on maternal behavior, and little is known about the etiology of these disorders. Although chronic stress is a significant risk factor for depression, it is unknown how chronic stress during lactation affects maternal behavior. Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior in lactating rats. It is h3T) 0thesized that the central AVP system may be a potential target for the treatment of postpartum behavioral disorders, as central manipulations of AVP alter behavior. The overall objective of the current protocol is to investigate the role of AVP in postpartum maternal behavior and aggression, and the effects of social stress on this system. The specific aims of the current proposal are to characterize the roles of central AVP, OXT, and CRH in the control of maternal behavior and maternal aggression, investigate the effects of chronic social stressors on these behaviors and central AVP, and investigate a potential AVP-mediated mechanism for the effects of chronic social stress on maternal behavior. These aims will be pursued using behavioral, endocrine, and molecular methods to quantify the effects of chronic social stressors, molecular and imaging (fMRI) techniques to identify the neural regions implicated in the acute and chronic control of maternal behavior, and stereotaxic surgical techniques to manipulate central AVP activity. The overall goal is to gain valuable training in behavioral neuroscience techniques and study the neuropeptidergic control of behavior. The long term career goal is to develop new targets and treatments for behavioral disorders of mothers. PUBLIC HEALTH RELEVANCE (See instructions): Although it is clear that the behavior of the mother affects the behavior and health of her children, very few studies have been directed at determining the causes of postpartum behavioral disorders. This application will help to ensure the health of mothers and their children by investigating potential mechanisms for the control of maternal behavior and causes for postpartum behavioral disorders.

说明（由申请人提供）：国家排雷中心的使命是确保每个人都健康地出生并得到需要，妇女不受生殖过程的有害影响，所有儿童都有机会充分发挥其健康和有所作为的潜力，不受疾病或残疾的影响，并通过最佳康复确保所有人的健康、生产力、独立性和福祉。产后焦虑和抑郁相关疾病可通过影响母亲行为对母亲和后代的健康产生负面影响，并且对这些疾病的病因知之甚少。虽然慢性压力是抑郁症的一个重要危险因素，但哺乳期的慢性压力如何影响母亲的行为尚不清楚。近年来的分子生物学研究表明，神经激素精氨酸加压素（AVP）、催产素（OXT）和皮质类固醇释放激素（CRH）可能参与哺乳期大鼠母性行为的调节。因此，中枢AVP系统可能是治疗产后行为障碍的潜在靶点，因为中枢对AVP的操纵改变了行为。目前的协议的总体目标是调查AVP在产后母亲的行为和攻击的作用，以及社会压力对这个系统的影响。目前的建议的具体目标是表征的作用，中央AVP，OXT和CRH在控制母亲的行为和母亲的侵略，调查慢性社会压力对这些行为和中央AVP的影响，并调查潜在的AVP介导的机制，慢性社会压力对母亲的行为的影响。这些目标将采用行为，内分泌和分子方法来量化慢性社会压力的影响，分子和成像（fMRI）技术，以确定涉及的急性和慢性控制产妇行为的神经区域，和立体定位手术技术来操纵中央AVP活动。总体目标是获得有价值的培训，在行为神经科学技术和研究神经肽能控制的行为。长期的职业目标是为母亲的行为障碍开发新的目标和治疗方法。 公共卫生相关性（见说明）：虽然很明显，母亲的行为会影响孩子的行为和健康，但很少有研究针对产后行为障碍的原因。这一应用将有助于通过调查控制产妇行为的潜在机制和产后行为障碍的原因，确保母亲及其子女的健康。