Project 5: Formation of Hazardous PAH Breakdown Products in Complex Env

项目5：复杂环境中有害PAH分解产物的形成

• 批准号: 8884146
• 负责人: Staci L Simonich
• 金额: $ 0.1万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8884146
• 关键词: Affect; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Availability; Biometry; Bioremediations; Chemicals; Chemistry; Complex; Computer Simulation; Creosote; Gas Chromatography; Health; Human; Instruction; Laboratories; Mass Spectrum Analysis; Measures; Methods; Modeling; Monitor; Oxidants; Parents; Particulate Matter; Peer Review; Property; Research Personnel; Research Support; Review Literature; Risk; Risk Assessment; Sampling; Site; Soil; Structure; Superfund; Technology; Testing; Time; Translational Research; Water; Wood material; Zebrafish; base; data sharing; new technology; oxidation; remediation; research study; superfund site; two-dimensional

PROJECT SUMMARY (See instructions): The most common ways to remediate polycyclic aromatic hydrocarbon (PAH) contamination at Superfund sites include chemical oxidation, bioremediation and thermal treatment. All of these remediation strategies have the potential to form hazardous oxy- and hydroxy-PAH breakdown products by oxidizing parent PAH. However, the peer-reviewed literature contains few studies of the formation of these chemicals during PAH remediation, for at least three reasons: the inability to predict which oxy- and hydroxy-PAHs will form in complex environmental mixtures, the complexity of the chemical analysis of oxy- and hydroxy-PAHs, and the historical lack of oxy- and hydroxy-PAH standards. As a result, regulatory agencies and researchers monitor the degradation of parent PAH during remediation of Superfund sites, but not the formation of hazardous PAH breakdown products. We hypothesize that parent PAHs transform into more persistent, water soluble, bioavailable, and toxic PAH breakdown products during the remediation of PAH-contaminated Superfund sites. Our first specific aim is to predict and measure PAH breakdown products formed from the oxidation of parent PAHs on the basis of computational modeling, controlled laboratory experiments, and two-dimensional gas chromatography equipped with time-of-flight mass spectrometry (GCxGC/ToF-MS). Our second specific aim is to measure PAH breakdown products directly in soils and sediments from former wood treatment Superfund sites, pre- and post-remediation, by GCxGC/ToF-MS. Our third specific aim is to determine which PAH remediation technologies minimize the formation of hazardous PAH breakdown products and assess the potential risk. We plan to measure soil and sediment samples from pilot scale remediation testing and determine if the parent, oxy-, and hydroxy-PAH concentrations increase or decrease with testing. We will determine which remediation conditions and soil and sediment properties affect the formation of hazardous PAH breakdown products. We will also collaborate with the Research Translation Core to provide guidance to Superfund managers regarding the human risk assessment of hazardous PAH breakdown products and appropriate remediation strategies to minimize their formation.

项目摘要（见说明）：在超级基金场地修复多环芳烃污染的最常见方法包括化学氧化、生物修复和热处理。所有这些补救策略都有可能通过氧化母体PAH形成有害的氧和羟基PAH分解产物。然而，同行评审的文献包含很少的研究，这些化学品的形成在多环芳烃整治，至少有三个原因：无法预测的氧和羟基多环芳烃将形成在复杂的环境混合物中，氧和羟基多环芳烃的化学分析的复杂性，以及历史上缺乏氧和羟基多环芳烃标准。因此，监管机构和研究人员在超级基金场地的补救过程中监测母体PAH的降解，但不监测有害PAH分解产物的形成。我们假设，家长多环芳烃转化为更持久的，水溶性的，生物可利用的，和有毒的多环芳烃分解产物在修复多环芳烃污染的超级基金网站。我们的第一个具体目标是预测和测量多环芳烃分解产物的基础上的计算建模，受控的实验室实验，二维气相色谱仪配备飞行时间质谱（GCxGC/ToF-MS）的父多环芳烃的氧化。我们的第二个具体目标是测量PAH分解产物直接在土壤和沉积物中从前木材处理超级基金网站，前和后的补救，通过GCxGC/ToF-MS。我们的第三个具体目标是确定哪些PAH补救技术最大限度地减少有害的PAH分解产物的形成，并评估潜在的风险。我们计划测量土壤和沉积物样品从试点规模的修复测试，并确定如果父母，氧，和羟基PAH浓度增加或减少的测试。我们将确定哪些修复条件和土壤和沉积物的性质会影响有害的PAH分解产物的形成。我们还将与Research Translation Core合作，就有害PAH分解产物的人类风险评估和适当的补救策略向超级基金经理提供指导，以尽量减少其形成。