Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
天然产物神经科学卓越研究中心 (CORE-NPN)
基本信息
- 批准号:8727081
- 负责人:
- 金额:$ 206.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-04 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgonistAntineoplastic AgentsApplications GrantsAreaAwardBasic ScienceBehavioralBiological AssayBiological FactorsCancer ControlCannabinoidsCenters of Research ExcellenceChemicalsClinicalClinical ResearchCocaine AbuseCollaborationsCommitCore FacilityDevelopmentDiseaseDrug KineticsEnsureEnvironmentEtiologyExtramural ActivitiesFacultyFoundationsFunctional disorderFundingGlaucomaGoalsGrantGrowthGrowth and Development functionHome environmentImmune systemInterdisciplinary StudyJournalsMentorsMississippiModelingMovementNational Center for Research ResourcesNausea and VomitingNervous system structureNeuraxisNeurodevelopmental DisorderNeuropharmacologyNeurosciencesObesityPatientsPharmacologic SubstancePharmacy SchoolsPhasePublicationsPublishingRecruitment ActivityReportingResearchResearch PersonnelResearch ProposalsResource DevelopmentResourcesRoleScientistTeacher Professional DevelopmentTechnologyTrainingTranslationsUnited States National Institutes of HealthUniversitiesWasting SyndromeWeight maintenance regimenWorkchemical synthesisexperiencegraduate studentin vitro Assayin vivoinnovationinsightmembermethamphetamine abusemultidisciplinaryneoplasticnervous system disorderneuropharmacologic agentnew growthnovelplant fungiprogramspublic health relevancesigma receptorsundergraduate student
项目摘要
DESCRIPTION (provided by applicant): The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated four years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. Faculty in the Center and its academic home, the School of Pharmacy, have already reported groundbreaking observations on the roles of cannabinoids and non-cannabinoids in the etiology of weight control, the control of the immune system, treatment of cancer, control of nausea and vomiting in patients receiving anti-neoplastic treatment, glaucoma, and the development of sigma receptor agonists in the treatment of cocaine and methamphetamine abuse. Also, CORE-NPN-supported investigators have increased their competitiveness by attracting extramural funds and publishing in leading journals of neuroscience. The Center will continue to provide an excellent environment for junior and mid-level investigators by working in close collaboration with leading national centers and scientists studying natural products to carry out the proposed projects that build on these novel insights into the pathophysiology of nervous system disorders. To achieve the goal of establishing an innovative and multidisciplinary Center focused on the use of natural products to manage neuropharmacologic disorders, the following Specific Aims are proposed: Aim 1 is to enhance the competitive independent research funding of four investigators, as detailed in their research proposals. In addition, external and internal renowned scientists in natural products neuroscience will continue to mentor all Center faculty members in basic and clinical neuroscience. Aim 2 is to sponsor a competitive small grant program that advances research in neuroscience related to the themes outlined in the proposal. Aim 3 is to continue the expansion of research resources for the development of innovative natural product neuropharmacology - related projects. Core facilities to accomplish this will include: a) acquisition of novel plants and fungi and isolation of biologically active natural products, b) chemical elucidation of the biologically active secondary metabolites and synthesis of derivatives, c) in vitro assays to identify biologically active natural products, and d) in vivo assays to evaluate behavioral studies of the biologically active natural products. Aim 4 is to continue faculty development and growth of new neuroscience investigators through training in cutting-edge technologies and to promote research opportunities in neuroscience for undergraduate and graduate students being mentored by Center faculty.
描述(申请人提供):密西西比大学药学院(UM)天然产品神经科学研究卓越研究中心(CORE-NPN)于四年前通过科布雷资助成立,已经建立了一个多学科团队,致力于评估天然产品对中枢神经系统(CNS)的影响。该中心现在有潜力开发和维持一个创新的、独立资助的研究中心,专注于治疗与神经系统相关的疾病。该中心及其学术中心药学院的教职员工已经报告了关于大麻和非大麻在体重控制的病因、免疫系统的控制、癌症的治疗、接受抗肿瘤治疗的患者的恶心和呕吐的控制、青光眼以及在治疗可卡因和甲基苯丙胺滥用的Sigma受体激动剂的开发方面的开创性观察。此外,由核心NPN支持的研究人员通过吸引校外资金并在领先的神经科学期刊上发表文章,增加了他们的竞争力。该中心将继续为初级和中级研究人员提供良好的环境,与研究天然产品的领先国家中心和科学家密切合作,实施拟议的项目,这些项目建立在对神经系统疾病病理生理学的这些新见解的基础上。为了实现建立一个创新的多学科中心的目标,重点是使用天然产品来管理神经药理学疾病,提出了以下具体目标:目标1是加强四名研究人员的竞争性独立研究资金,这在他们的研究提案中有详细说明。此外,在天然产品神经科学领域的外部和内部知名科学家将继续指导中心所有基础和临床神经科学的教职员工。目标2是赞助一个竞争性的小额拨款计划,促进与提案中概述的主题相关的神经科学研究。目标3是继续扩大研究资源,用于开发创新的天然产品神经药理学相关项目。实现这一目标的核心设施将包括:a)获得新的植物和真菌并分离具有生物活性的天然产物;b)对具有生物活性的次生代谢物进行化学鉴定和合成衍生物;c)进行体外试验以鉴定具有生物活性的天然产物;以及d)进行体内试验以评价具有生物活性的天然产物的行为研究。目标4是通过在尖端技术方面的培训,继续发展和培养新的神经科学研究人员,并促进由中心教师指导的本科生和研究生在神经科学方面的研究机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephen John Cutler其他文献
Stephen John Cutler的其他文献
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{{ truncateString('Stephen John Cutler', 18)}}的其他基金
Center of Research Excellence in Natural Products Neuro*
天然产物神经卓越研究中心*
- 批准号:
7895299 - 财政年份:2009
- 资助金额:
$ 206.34万 - 项目类别:
Center of Research Excellence in Natural Products Neuro*
天然产物神经卓越研究中心*
- 批准号:
7440263 - 财政年份:2006
- 资助金额:
$ 206.34万 - 项目类别:
Center of Research Excellence in Natural Products Neuro*
天然产物神经卓越研究中心*
- 批准号:
7284169 - 财政年份:2006
- 资助金额:
$ 206.34万 - 项目类别:
Center of Research Excellence in Natural Products Neuro*
天然产物神经卓越研究中心*
- 批准号:
7893558 - 财政年份:2006
- 资助金额:
$ 206.34万 - 项目类别:
Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
天然产物神经科学卓越研究中心 (CORE-NPN)
- 批准号:
8550120 - 财政年份:2006
- 资助金额:
$ 206.34万 - 项目类别:
Center of Research Excellence in Natural Products Neuro*
天然产物神经卓越研究中心*
- 批准号:
7632046 - 财政年份:2006
- 资助金额:
$ 206.34万 - 项目类别:
Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
天然产物神经科学卓越研究中心 (CORE-NPN)
- 批准号:
8337505 - 财政年份:2006
- 资助金额:
$ 206.34万 - 项目类别:
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