Broad Institute Center for Cancer Systems Biology

拟议的布罗德研究所癌症系统生物学中心代表了多名研究人员的努力， 有几个具体的目标。首先，我们的目标是创建和维持一个充满活力的癌症生物学家社区 以及致力于探索癌症系统生物学这一新兴领域的计算科学家。这将是 包括维护一个丰富的智力环境，严格开发新的、高度集成的 癌症研究的实验和计算方法。这将涉及到培训下一代 越来越精通癌症生物学/计算生物学的癌症研究人员 界面，通过开发和传播计算工具(软件)，跨学科 培训和多媒体教育材料。此外，该中心将聘用一名雄心勃勃的多人调查员。 旨在确定不同癌症的必要基因(跟腱)的研究项目 类型，并开发先进的计算模型，利用癌细胞的分子特征 预测一下这些要素。如果成功，这一努力将产生对分子电路的两个新见解 还将提供一条通往个性化癌症药物的新途径，从而使 患者肿瘤的分子特征可以预测他们对特定治疗的反应。

The proposed Broad Institute Center for Cancer Systems Biology represents a multi-investigator effort that has several concrete goals. First, we aim to create and maintain a vibrant community of cancer biologists and computational scientists devoted to exploring the emerging field of cancer systems biology. This will involve maintaining a rich intellectual environment that rigorously develops new, and highly integrated experimental and computational approaches to cancer research. This will involve training a next generation of cancer researchers who become increasingly expert at this cancer biology / computational biology interface, through the development and dissemination of computational tools (software), cross-disciplinary training, and multimedia educational materials. In addition, the Center will take on an ambitious, multiinvestigator research project aimed at identifying the essential genes (Achilles' Heels) of cancers of different types, and developing advanced computational models that use the molecular features of cancer cells to predict these essentialities. If successful, this effort would yield both new insights into the molecular circuitry of cancer cells, and would also provide a new path towards personalized cancer medicine, whereby the molecular features of a patient's tumor are predictive of their response to specific therapy.