Broad Institute LINCS Center for Transcriptomics

布罗德研究所 LINCS 转录组学中心

• 批准号: 8787845
• 负责人: TODD R. GOLUB
• 金额: $ 209.28万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-10 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8787845
• 关键词: Biological; Biology; Biomedical Research; Clustered Regularly Interspaced Short Palindromic Repeats; Communities; Data; Development; Disease; Education and Outreach; Gene Expression; Genes; Genetic; Genome; Goals; Health Sciences; Institutes; Institution; Internet; Knock-out; Link; Maps; Methods; Open Reading Frames; Pathway interactions; Pharmaceutical Preparations; Phase; Physiological; Physiology; Reading; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Source; Therapeutic Effect; United States National Institutes of Health; Work; analytical tool; base; cell type; cloud based; cost; design; knock-down; mRNA Expression; novel strategies; overexpression; programs; protein function; public health relevance; repository; scale up; small hairpin RNA; small molecule; tool; transcriptomics; user-friendly

DESCRIPTION (provided by applicant): The overall goal of this LINCS Center is to make it to generate large-scale pharmacological and genetic perturbations of a large panel of cell types, develop analytical tools that enable researchers to make biological discoveries from the data, and to make those data and tools broadly available to the research community. We will accomplish this using the L1000 transcriptional profiling method developed by our Center, and by creating a cloud-based computing infrastructure that supports data APIs and web apps designed make it possible for biologists lacking computational expertise to make LINCS-based discoveries.

描述（由申请人提供）：该Lincs中心的总体目标是使其生成大型细胞类型面板的大规模药理和遗传扰动，开发分析工具，使研究人员能够从数据中获得生物学发现，并使这些数据和工具可为研究社区广泛使用。我们将使用中心开发的L1000转录分析方法来实现此目的，并通过创建支持数据API和Web应用程序的基于云的计算基础架构，这使得缺乏计算专业知识的生物学家可以使基于Lincs的发现成为可能。