Regulation of Cell Motility by the Oncogenic ERK-MAPK Pathway
致癌 ERK-MAPK 途径对细胞运动的调节
基本信息
- 批准号:8534066
- 负责人:
- 金额:$ 0.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2014-01-01
- 项目状态:已结题
- 来源:
- 关键词:ActinsActomyosinAddressAdhesionsAntibodiesAutomobile DrivingBRAF geneBasic ScienceBiochemicalCancer EtiologyCancer cell lineCarcinomaCell LineCell modelCellsCellular biologyChemicalsComplexComputer softwareComputing MethodologiesCytoskeletonDataDissectionDisseminated Malignant NeoplasmDistantDoctor of PhilosophyEpithelialEpithelial CellsExhibitsFluorescence MicroscopyFutureGeneticGenetic TranscriptionGoalsImageIn VitroKRAS2 geneLabelLocationMAP Kinase GeneMalignant NeoplasmsMalignant neoplasm of pancreasManuscriptsMechanicsMentorsMicroscopyMitogen-Activated Protein KinasesModelingMolecularMorbidity - disease rateMorphologyMovementMutationMyosin Light ChainsNeoplasm MetastasisNormal CellOncogenicOrganPathway interactionsPatientsPhosphorylationPhosphotransferasesProductionPublishingRPS6KA geneReceptor Protein-Tyrosine KinasesRegulationResearchRibosomal Protein S6 KinaseRoleScienceScientistSignal PathwaySignal TransductionSiteSpeedStratificationTechniquesTestingTherapeuticTimeTissue MicroarrayTissue SampleTissuesTrainingTraining ProgramsZYX geneanticancer researchbasecancer cellcancer typecareercell motilitycell transformationepithelial to mesenchymal transitionimprovedmalignant breast neoplasmmedical schoolsmelanomamigrationmortalitymutantmyosin phosphataseneoplastic cellnew therapeutic targetnovelparticlepaxillinpolymerizationpreventprofessorprogramsspatiotemporaltreatment strategy
项目摘要
DESCRIPTION (provided by applicant): This proposal outlines a training program that will enable the transition to an independent career in cancer research. The candidate has a Ph.D. in Biomedical Sciences and is trained in genetic and biochemical techniques used to study cell motility and cell signaling. She is currently mentored by Dr. John Blenis, Professor of Cell Biology at Harvard Medical School. Dr. Blenis is one of the world's leaders in mechanistic dissection of the Ras/ERK and PI3K/mTORC1 oncogenic signaling pathways. The training program includes new mentoring from Dr. Gaudenz Danuser, Professor of Cell Biology at Harvard Medical School. Dr. Danuser is an innovator in developing new computational methods to address previously un-attainable questions in chemical and mechanical signaling. The candidate is researching the transcription-independent mechanisms by which ERK and RSK regulate cell motility in untransformed model cells and transformed cancer cells. In the short term, the proposed research program will provide training in advanced quantitative imaging of actomyosin dynamics, a new technique for the candidate, and will provide time for her to publish additional manuscripts and transition her studies cancer cell migration and invasion. She has identified several components of the actomyosin machinery, such as MYPT1, as novel ERK/RSK substrates and will further investigate their role in driving cancer cell migration and invasion. Thus, this training program will prepare the candidate to become an independent scientist, with a long-term research program that integrates biochemical studies with microscopy-based dissection of cytoskeletal dynamics to understand the signaling mechanisms that drive cancer cell motility. This basic research will uncover fundamental mechanisms of cancer cell migration relevant to multiple cancer types and will inform upon therapeutic strategies targeting cancers with activated ERK/RSK signaling.
描述(由申请人提供):本提案概述了一个培训计划,将使过渡到一个独立的职业生涯在癌症研究。候选人拥有博士学位。他在生物医学科学领域接受过遗传和生物化学技术方面的培训,这些技术用于研究细胞运动和细胞信号。她目前由哈佛医学院细胞生物学教授John Blenis博士指导。Blenis博士是Ras/ERK和PI 3 K/mTORC 1致癌信号通路机制研究的世界领导者之一。培训计划包括来自哈佛医学院细胞生物学教授Gaudenz Danuser博士的新指导。Danuser博士是开发新计算方法的创新者,以解决化学和机械信号中以前无法实现的问题。该候选人正在研究ERK和RSK调节未转化模型细胞和转化癌细胞中细胞运动的转录非依赖性机制。在短期内,拟议的研究计划将提供先进的肌动球蛋白动力学定量成像的培训,这是候选人的一项新技术,并将为她提供时间发表更多的手稿,并将她的研究转移到癌细胞迁移和入侵。她已经确定了肌动球蛋白机制的几种组分,如MYPT 1,作为新型ERK/RSK底物,并将进一步研究它们在驱动癌细胞迁移和侵袭中的作用。因此,这个培训计划将准备候选人成为一个独立的科学家,与一个长期的研究计划,将生化研究与细胞骨架动力学的显微镜解剖相结合,以了解驱动癌细胞运动的信号机制。这项基础研究将揭示与多种癌症类型相关的癌细胞迁移的基本机制,并将为靶向具有活化ERK/RSK信号传导的癌症的治疗策略提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michelle Christine Mendoza其他文献
Michelle Christine Mendoza的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michelle Christine Mendoza', 18)}}的其他基金
Cancer invasion: reciprocity between the extracellular matrix and intrinsic ERK signaling
癌症侵袭:细胞外基质和内在 ERK 信号传导之间的相互作用
- 批准号:
10367122 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Cancer invasion: reciprocity between the extracellular matrix and intrinsic ERK signaling
癌症侵袭:细胞外基质和内在 ERK 信号传导之间的相互作用
- 批准号:
10622474 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Kinase Control of Synergistic Cell Migration Mechanics
协同细胞迁移机制的激酶控制
- 批准号:
10618280 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Kinase Control of Synergistic Cell Migration Mechanics
协同细胞迁移机制的激酶控制
- 批准号:
10797833 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Cancer invasion: reciprocity between the extracellular matrix and intrinsic ERK signaling
癌症侵袭:细胞外基质和内在 ERK 信号传导之间的相互作用
- 批准号:
10745809 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Kinase Control of Synergistic Cell Migration Mechanics
协同细胞迁移机制的激酶控制
- 批准号:
10446072 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Regulation of Cell Motility by the Oncogenic ERK-MAPK Pathway
致癌 ERK-MAPK 途径对细胞运动的调节
- 批准号:
9110652 - 财政年份:2015
- 资助金额:
$ 0.64万 - 项目类别:
Regulation of Cell Motility by the Oncogenic ERK-MAPK Pathway
致癌 ERK-MAPK 途径对细胞运动的调节
- 批准号:
9128587 - 财政年份:2015
- 资助金额:
$ 0.64万 - 项目类别:
Regulation of Cell Motility by the Oncogenic ERK-MAPK Pathway
致癌 ERK-MAPK 途径对细胞运动的调节
- 批准号:
8754917 - 财政年份:2012
- 资助金额:
$ 0.64万 - 项目类别:
Regulation of Cell Motility by the Oncogenic ERK-MAPK Pathway
致癌 ERK-MAPK 途径对细胞运动的调节
- 批准号:
8351580 - 财政年份:2012
- 资助金额:
$ 0.64万 - 项目类别:
相似国自然基金
由actomyosin介导的集体性细胞迁移对唇腭裂发生的影响的研究
- 批准号:82360313
- 批准年份:2023
- 资助金额:32 万元
- 项目类别:地区科学基金项目
相似海外基金
Nuclear force feedback as rheostat for actomyosin tension control
核力反馈作为肌动球蛋白张力控制的变阻器
- 批准号:
MR/Y001125/1 - 财政年份:2024
- 资助金额:
$ 0.64万 - 项目类别:
Research Grant
CAREER: Cytokinesis without an actomyosin ring and its coordination with organelle division
职业:没有肌动球蛋白环的细胞分裂及其与细胞器分裂的协调
- 批准号:
2337141 - 财政年份:2024
- 资助金额:
$ 0.64万 - 项目类别:
Continuing Grant
CAREER: Computational and Theoretical Investigation of Actomyosin Contraction Systems
职业:肌动球蛋白收缩系统的计算和理论研究
- 批准号:
2340865 - 财政年份:2024
- 资助金额:
$ 0.64万 - 项目类别:
Continuing Grant
Elucidation of the mechanism by which actomyosin emerges cell chirality
阐明肌动球蛋白出现细胞手性的机制
- 批准号:
23K14186 - 财政年份:2023
- 资助金额:
$ 0.64万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Deciphering actomyosin contractility regulation during incomplete germ cell division
破译不完全生殖细胞分裂过程中肌动球蛋白收缩性的调节
- 批准号:
573067-2022 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
University Undergraduate Student Research Awards
CAREER: Actuating robots with actomyosin active gels
职业:用肌动球蛋白活性凝胶驱动机器人
- 批准号:
2144380 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Continuing Grant
Collaborative Research: Mechanics of Reconstituted Self-Organized Contractile Actomyosin Systems
合作研究:重建自组织收缩肌动球蛋白系统的力学
- 批准号:
2201236 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Standard Grant
Collaborative Research: Mechanics of Reconstituted Self-Organized Contractile Actomyosin Systems
合作研究:重建自组织收缩肌动球蛋白系统的力学
- 批准号:
2201235 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Standard Grant
Coordination of actomyosin and anillo-septin sub-networks of the contractile ring during cytokinesis
胞质分裂过程中收缩环肌动球蛋白和 anillo-septin 子网络的协调
- 批准号:
463633 - 财政年份:2022
- 资助金额:
$ 0.64万 - 项目类别:
Operating Grants
The integrin-dependent B cell actomyosin network drives immune synapse formation and B cell functions
整合素依赖性 B 细胞肌动球蛋白网络驱动免疫突触形成和 B 细胞功能
- 批准号:
546047-2020 - 财政年份:2021
- 资助金额:
$ 0.64万 - 项目类别:
Postdoctoral Fellowships