Low-Dose MRI-Compatible Molecular Breast Imaging Device
低剂量 MRI 兼容分子乳腺成像设备
基本信息
- 批准号:8525076
- 负责人:
- 金额:$ 66.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-01 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAmerican Cancer SocietyAnatomyAppearanceBiochemicalBiomedical EngineeringBreastBreast Cancer DetectionCancer DetectionCancer PatientCaringClinicalClinical TrialsCommunity Clinical Oncology ProgramDevelopmentDevicesDoseDuct (organ) structureEarly DiagnosisEducational process of instructingGoalsHigh Risk WomanHousingHumanImageImaging DeviceIndividualLeadMagnetic Resonance ImagingMalignant NeoplasmsMammographyMarketingModalityMolecularMorphologic artifactsPET/CT scanPatientsPharmaceutical PreparationsPhasePositronPositron-Emission TomographyPredictive ValuePrevention therapyPricePublishingReportingResolutionSalesSiliconSiteSmall Business Innovation Research GrantSpecificitySystemTestingUnited States National Institutes of HealthUnnecessary ProceduresWomanWorkcancer preventioncommercializationdesign and constructiondiagnostic accuracyimprovedinnovationlifetime riskmalignant breast neoplasmmolecular imagingphotomultiplierpublic health relevancescreeningstudy characteristicssuccessyoung woman
项目摘要
DESCRIPTION (provided by applicant): Contrast-enhanced MRI has been proven to be a very sensitive modality for the early diagnosis of breast cancer in young women and/or in women with radiographically-dense breasts. The American Cancer Society recommends that high-risk women with lifetime risk greater than 20% should receive annual breast MRI screening. Depending on the practitioner and study characteristics, MRI may have a high false positive rate (with specificity reported as low as 81%), which can lead to many unnecessary procedures or even over-treatment. Positron emission mammography ("PEM"), the breast-specific high-resolution molecular imaging system originally invented by the PI of the submitted proposal, has been demonstrated to have a high negative predictive value. Integrating a PEM system into MRI for combined imaging is therefore likely to increase diagnostic accuracy. Furthermore, the recent commercialization of PET/CT and PET/MR clinical systems has led to wide acceptance in the oncology community for combined anatomic and molecular imaging. The goal of this application is therefore to design and construct a PEM system that could be used in conjunction with an MRI scanner. The developed PEM/MRI system in this project could be used in cancer detection, in personalizing care for breast cancer patients, and in the development of new drugs for prevention and therapy.
描述(由申请人提供):对比增强MRI已被证明是一种非常敏感的方式,可用于年轻女性和/或乳房放射学致密的女性的乳腺癌早期诊断。美国癌症协会建议,终身风险超过20%的高危女性应该每年接受乳房核磁共振检查。根据不同的从业者和研究特点,MRI可能有很高的假阳性率(特异性低至81%),这可能导致许多不必要的手术甚至过度治疗。正电子发射乳房x线照相术(PEM)是由提交提案的PI最初发明的乳房特异性高分辨率分子成像系统,已被证明具有很高的阴性预测值。因此,将PEM系统集成到MRI中进行联合成像可能会提高诊断准确性。此外,最近PET/CT和PET/MR临床系统的商业化已经导致肿瘤界广泛接受结合解剖和分子成像。因此,本应用程序的目标是设计和构建一个可以与MRI扫描仪结合使用的PEM系统。本项目开发的PEM/MRI系统可用于癌症检测、乳腺癌患者个性化护理以及预防和治疗新药的开发。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Irving Weinberg其他文献
Irving Weinberg的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Irving Weinberg', 18)}}的其他基金
Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease
普鲁士蓝无创有效脑部输送治疗阿尔茨海默病
- 批准号:
9908814 - 财政年份:2019
- 资助金额:
$ 66.63万 - 项目类别:
Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease
普鲁士蓝无创有效脑部输送治疗阿尔茨海默病
- 批准号:
10210039 - 财政年份:2019
- 资助金额:
$ 66.63万 - 项目类别:
Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease
普鲁士蓝无创有效脑部输送治疗阿尔茨海默病
- 批准号:
10247835 - 财政年份:2019
- 资助金额:
$ 66.63万 - 项目类别:
Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease
普鲁士蓝无创有效脑部输送治疗阿尔茨海默病
- 批准号:
10092710 - 财政年份:2019
- 资助金额:
$ 66.63万 - 项目类别:
Targeting Deep Brain Tumors with MRI-Insertable Magnetic Gradients and Nanopartic
利用 MRI 可插入磁梯度和纳米颗粒靶向深部脑肿瘤
- 批准号:
8524216 - 财政年份:2013
- 资助金额:
$ 66.63万 - 项目类别:
Novel MRI Gradient Coil Manufacturing Methods
新型 MRI 梯度线圈制造方法
- 批准号:
8312984 - 财政年份:2012
- 资助金额:
$ 66.63万 - 项目类别:
High-quality compact portable low-field head MRI with ultra-fast gradients
具有超快梯度的高质量紧凑型便携式低场头部 MRI
- 批准号:
9328157 - 财政年份:2011
- 资助金额:
$ 66.63万 - 项目类别:
Image Guidance Method for Diabetic Foot Surgery
糖尿病足手术的图像引导方法
- 批准号:
7999884 - 财政年份:2010
- 资助金额:
$ 66.63万 - 项目类别:
Low-Dose MRI-Compatible Molecular Breast Imaging Device
低剂量 MRI 兼容分子乳腺成像设备
- 批准号:
8669785 - 财政年份:2010
- 资助金额:
$ 66.63万 - 项目类别:
Low-Dose MRI-Compatible Molecular Breast Imaging Device
低剂量 MRI 兼容分子乳腺成像设备
- 批准号:
7800343 - 财政年份:2010
- 资助金额:
$ 66.63万 - 项目类别:
相似海外基金
Improving Vaccination Rates Nationwide through Partnerships between the American Cancer Society
通过美国癌症协会之间的合作提高全国范围内的疫苗接种率
- 批准号:
8916862 - 财政年份:2014
- 资助金额:
$ 66.63万 - 项目类别: