Global Identification of Dengue Virus Epitopes Following Exposure, Vaccination, and Acute Infection

根据大规模T细胞表位发现计划授予的合同建立了高度互动的多学科团队，他们的研究努力集中于大规模发现与新出现和再次出现的传染病和潜在的生物恐怖主义病原体相关的T细胞表位。项目是里程碑式的，必须包括：1)表位鉴定；2)对原代人类T细胞进行体外表位验证研究，以证明所有新定义的T细胞表位与经典或非经典MHC分子结合的免疫原性/抗原性或诊断潜力；以及3)向免疫表位数据库提交所有表位信息和计算机软件，以便于更广泛的研究社区访问和使用数据和工具。

The contracts awarded under the Large Scale T Cell Epitope Discovery program establish highly interactive multi-disciplinary teams whose research efforts are focused on large-scale discovery of T cell epitopes associated with microorganisms responsible for emerging and re-emerging infectious diseases and potential agents of bioterrorism. Projects are milestone driven and must include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database to facilitate access and use of the data and tools by the broader research community.