3rd ASM Conference on Viral Manipulation of Nuclear Processes

 描述(由申请人提供)：长期以来，核内的病毒-宿主相互作用一直被认为在决定病毒感染的过程中发挥着重要作用。基因组由RNA(如逆转录病毒和流感病毒)或DNA(如多瘤病毒、乳头瘤病毒、腺病毒和疱疹病毒)组成的病毒家族与许多相同的宿主细胞途径相互作用。每个病毒家族还制定了独特的策略，以创造有利于病毒基因表达和生产性复制的核环境。研究RNA和DNA病毒的研究人员经常参加不同的会议，这种分离限制了我们对行动模式的共性的理解。这项提议要求提供资金，以部分支持题为“核过程的病毒操纵”的会议，该会议将把研究RNA和DNA病毒的研究人员聚集在一起，讨论共同感兴趣的领域。该会议由美国微生物学会(ASM)主办，将于2014年10月30日至11月2日在华盛顿的Omni Shoreham酒店举行。在这次会议之前，2008年在南卡罗来纳州查尔斯顿和2011年在新墨西哥州圣达菲就这一主题举行了两次非常成功的会议。杰出的研究人员被邀请担任主席和演讲人。此外，我们还邀请了来自该领域外的主旨演讲者，他们将对核心信令和架构的基本问题进行一般感兴趣的介绍。所有其他演讲将被选为口头演讲或从提交的摘要中张贴海报。通过这种方式，我们将确保展示研究的前言，并将鼓励年轻研究人员参与。组委会由来自不同病毒学领域的知名领导人组成。他们将负责从提交的摘要中挑选发言者，并负责挑选旅行奖项的获奖者。将在会议规划和组织的每个阶段作出协调一致的努力，以确保妇女和少数群体的参与。我们要求提供资金，以支付初级发言人的旅费和住宿费，并为年轻调查人员提供旅费奖励。这次会议旨在探索新出现的和新类型的宿主-病毒相互作用。它将强调病毒如何改变核结构，调节细胞转录本的表达，操纵DNA复制和修复机制，并进化出克服细胞核内宿主固有免疫监视机制的策略。这些都是病毒学中的重要领域，将为病毒的发病机制提供新的见解。这些主题将在五个会议上讨论：1)宿主途径的病毒操纵，2)核结构的病毒重塑，3)病毒和DNA损伤反应，4)病毒-染色质相互作用，以及5)病毒-宿主相互作用。会议将为讨论病毒学面临的热点问题提供一个论坛，并将促进新的互动，特别是研究不同病毒家族的初级和高级研究人员之间的互动。我们预计，提出的主题将促进病毒学领域的合作，并促进促进人类健康的令人兴奋的新方法。

 DESCRIPTION (provided by the applicant): Virus-host interactions in the nucleus have long been recognized as playing important roles in determining the course of viral infection. Families of viruses with genomes composed of RNA (e.g. retroviruses and influenza) or DNA (e.g. polyomaviruses, papillomaviruses, adenoviruses and herpesviruses) interact with many of the same host cell pathways. Each virus family has also evolved unique strategies to create a nuclear environment conducive to viral gene expression and productive replication. Investigators studying RNA and DNA viruses often attend separate meetings, and this separation has limited our appreciation of the commonalities in modes of action. This proposal requests funds to assist in partial support of a meeting entitled "Viral Manipulation of Nuclear Processes" that will bring together researchers who work on both RNA and DNA viruses to discuss areas of common interest. The meeting is sponsored by the American Society for Microbiology (ASM) and will be held at the Omni Shoreham Hotel in Washington, DC (October 30 to November 2, 2014). This meeting follows two highly successful previous meetings on this topic held in 2008 in Charleston, SC and in 2011 in Santa Fe, NM. Outstanding researchers have been invited to serve as chairs and speakers. In addition we have invited Keynote speakers from outside the field, who will give general interest introductions to fundamental issues of signaling and architecture in the nucleus. All other presentations will be chosen for either oral talks or posters from submitted abstracts. In this way we will ensure that the forefron of research is presented and will encourage participation of younger researchers. The Organizing Committee consists of established leaders from different areas of virology. They will be responsible for selection of speakers from submitted abstracts and for choosing recipients of travel awards. A concerted effort will be made at every stage of the meeting planning and organization to ensure inclusion of women and minorities. We request funds to cover travel costs and accommodation of junior speakers and provide travel awards for young investigators. This meeting is designed to explore emerging and novel types of host-virus interactions. It will emphasize how viruses alter nuclear architecture, modulate expression of cellular transcripts, manipulate DNA replication and repair machinery, and have evolved strategies to overcome host innate immune surveillance mechanisms in the nucleus. These are significant areas in virology that will provide new insights into viral pathogenesis. These topics will be addressed in five sessions: 1) Viral Manipulation of Host Pathways, 2) Viral Remodeling of Nuclear Architecture, 3) Viruses and DNA Damage Responses, 4) Virus-Chromatin Interactions, and 5) Virus-Host Interactions. The meeting will provide a forum for discussion of topical issues confronting virology, and will foster new interactions, particularly between junior and senior investigators working on different virus families. We anticipate that the topics presented will stimulate collaborations across virology and promote exciting new approaches to advance human health.