Neurological Sciences Academic Development at CNMC.

CNMC 神经科学学术发展。

• 批准号: 8688368
• 负责人: Roger Packer
• 金额: $ 15.43万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8688368
• 关键词: Acute Brain Injuries; Area; Award; Biologically Based Therapy; Child; Childhood; Clinical Research; Collaborations; Development; Disease; Disorder of neurometabolic regulation; Elements; Ensure; Extramural Activities; Faculty; Fellowship Program; Goals; Grant; Image; Laboratories; Lead; Mentors; Mentorship; Molecular; Molecular Genetics; National Institute of Neurological Disorders and Stroke; Neurologic; Neurologist; Neuromuscular Diseases; Neuropsychology; Neurosciences; Only Child; Pediatric Hospitals; Pediatric Neurology; Physicians; Positioning Attribute; Process; Research; Research Personnel; Role; Science; Scientist; Stress; Structure; Techniques; Training; Training Programs; Translational Research; career; cellular imaging; cohort; design; developmental disease; developmental neurobiology; experience; innovation; medical schools; member; multidisciplinary; neuro-oncology; neurogenetics; neuroprotection; programs; responsible research conduct; skills; success; translational neuroscience

DESCRIPTION (provided by applicant): With child neurology entering a new era, there is a critical need to develop a new cohort of investigators who not only understand the molecular underpinnings of childhood neurologic disease, but are also well- trained in translational neuroscience to develop biologically-based therapies and perform translational research. The goals of the NSADA training program, of which we are asking renewal, are to promote the development of the basic clinical and translational research skills of child neurologists, encourage these promising junior faculty members to focus their efforts on important problems in child neurology, and to train a cohort of junior investigators to become leaders in pediatric neurology, focusing on multidisciplinary translational research. We propose to train 3 child neurologists over the period of the award and, at the end of training, expect these awardees to have the skills to perform important clinical and translational research in neurologic conditions o childhood, to be able to assume tenure track positions in medical schools with departments, and to be able to compete successfully for extramural grant support. This award will focus on training in important areas in child neurology including neuro-oncology, neuromuscular disorders, neurogenetic and neurometabolic diseases, developmental neurobiology/developmental disorders and acute brain injury/neuroprotection. Over the first grant cycle, the NSADA program at CNMC was granted two awardees, and through innovative mechanisms, in collaboration with the academic office of CNMC and NINDS, was able to train 3 excellent young physicians who are pursuing academic careers and are successfully competing for extramural grant support. The CNMC NSADA program has experience in training young physician scientists and has a well-organized programmatic structure. A cohort of experienced mentors have agreed to participate in the program; mentors who are experienced in training young physician scientists and have shown the ability to obtain independent extramural support for their research. They all have well-established laboratories and are tenured at CNMC or affiliated programs, further substantiating their ability to perform their mentoring roles. It is expected that each awardees will have a strong mentoring team led by one experienced mentor, and that there will be significant safeguards built into the program to ensure the awardees' success. Each awardee will have a detailed training program, including a didactic educational program which is individualized, but stresses common elements including training and responsible conducts of research, statistical design, and innovative molecular and neurophysiologic techniques. Core laboratory programs in molecular genetics, cellular imaging, and cellular neuroscience, Neuro-imaging, neuropsychology, and statistical design and analysis will be offered to all candidates. The program will utilize a well-developed selection process to both identify appropriate awardees and mentors (mentorship team). There are strong potential candidates in place in the CNMC fellowship program; however, the program will also reach outside its own program to attract awardees and has a well-developed plan for recruitment and retention plan to enhance diversity. The growing research and academic programs at CNMC, including its award of being the only children's hospital to lead a CTSA and one of two pediatric hospitals to be included in the NEXT consortium, also ensures the awardees' success within the NSADA program.

描述（由申请人提供）：随着儿童神经病学进入一个新时代，至关重要的需要开发新的研究人员，他们不仅了解儿童神经系统疾病的分子基础，而且对转化神经科学的培训也接受了良好的培训以开发基于生物学的疗法和进行转化研究。 NSADA培训计划的目标（我们要续签）是为了促进儿童神经科医生的基本临床和转化研究技能的发展，鼓励这些有前途的初级教师将精力集中在儿童神经病学上的重要问题，并培训一名初级研究人员成为儿童神经病学领导者的同学，专注于多学院的学术翻译。我们建议在奖项期间培训3名儿童神经科医生，并希望在培训结束时，希望这些获奖者具有在神经状况下进行重要的临床和转化研究的技能。该奖项将重点介绍儿童神经病学重要领域的培训，包括神经肿瘤学，神经肌肉疾病，神经遗传和神经代谢疾病，发育性神经生物学/发育障碍以及急性脑损伤/神经保护作用。在第一个赠款周期中，CNMC的NSADA计划获得了两名获奖者，并且通过创新的机制与CNMC和Ninds的学术办公室合作，能够培训3名从事学术职业并成功竞争外部赠款支持的优秀年轻医生。 CNMC NSADA计划具有培训年轻医师科学家的经验，并且具有良好的程序结构。一群经验丰富的导师同意参加该计划；在培训年轻医师科学家并表现出获得独立研究后支持的能力方面经验丰富的导师。他们都有公认的实验室，并在CNMC或附属计划中任职，进一步证实了他们执行指导角色的能力。预计每个获奖者将拥有一个由一位经验丰富的导师领导的强大指导团队，并且该计划中会有大量的保障措施，以确保获奖者的成功。每个获奖者将有一个详细的培训计划，包括一个是个性化的教学教育计划，但强调共同的要素，包括培训和负责任的研究，统计设计以及创新的分子和神经生理技术。分子遗传学，细胞成像和细胞神经科学，神经图像，神经心理学以及统计设计和分析的核心实验室计划将提供给所有候选者。该计划将利用完善的选择过程来确定适当的获奖者和指导者（指导团队）。 CNMC奖学金计划中有强大的潜在候选人；但是，该计划还将在其自己的计划之外吸引获奖者，并制定制定良好的招聘和保留计划，以增强多样性。 CNMC的研究和学术课程不断发展，包括授予唯一领导CTSA的儿童医院，以及两家儿科医院之一被包括在下一个财团中，还确保了获奖者在NSADA计划中的成功。