The Role of Altered Permeability in Bladder Diseases

描述(由申请人提供)：我们假设有一个与急性或慢性因素相关的统一机制，这些因素破坏了通常保护膀胱的不渗透屏障。因此，我们认为膀胱通透性增加是许多良性膀胱疾病的根本原因。(1)在膀胱再生中，由于新生器官对尿液的渗透性，愈合和纤维化之间的竞赛倾向于纤维化，我们将通过动物模型研究再生膀胱的渗透性降低如何促进愈合。(2)在IC/PBS中，由渗漏引起的感觉神经去极化和结构改变是其病理基础。共病研究表明，肠和膀胱之间存在一种相互作用的关系，其中一种的变化会导致另一种的通透性变化，这种相互作用的动物研究将揭示与临床人群相关的机制。渗透性增加也可能是OAB的一个因素。因此，我们计划进行一项临床研究，以确定IC/PBS、CPP和LUTS的通透性增加作为衰老的函数的作用。

DESCRIPTION (provided by applicant): We hypothesize that there is a unifying mechanism associated with acute or chronic factors that damage the impermeability barrier that normally protects the bladder. Thus, we propose that increased permeability of the bladder is a root cause of many benign bladder diseases. (1) In bladder regeneration, the race between healing and fibrosis is tipped in favor of fibrosis by permeability of the nascent organ to urine, and we will investigate with animal models how decreasing permeability of the regenerating bladder facilitates healing. (2) In IC/PBS, depolarization of sensory nerves and structural changes induced by leakiness underlie that pathology. Comorbidity studies suggest that a reciprocal relationship exists between bowel and bladder such that changes in one induces permeability changes in the other, and animal studies of this reciprocity will reveal mechanisms relevant to clinical populations. Increased permeability may be a factor in OAB as well. We, therefore, plan a clinical study to determine the role of increased permeability in IC/PBS and CPP and LUTS as a function of aging.