T2 relaxation time in the OAI normal, incidence and progression cohorts

基于NIAMS赞助的OAI，这项研究将提供关于MR基础上的角色的独特信息 T2松弛时间软骨生物标记物预测和监测膝关节骨关节炎高危人群 与健康对照相关的骨性关节炎和早期骨性关节炎的因素。具体目标是： (1)应用半定量积分研究软骨和半月板损伤的患病率和分级 正常人(n=100)的器官磁共振成像评分(蠕虫)，来自 45-70岁OAI的发病(危险因素)(n=300)和进展(早期骨关节炎)(n=300)队列； 并分析这些评分与T2参数(平均值、空间分布和层流)的关系 组织)，并评估三个小组之间的相互关系。 (2)确定基线T2参数(平均值、空间分布和层流组织)是否可以预测 蠕虫分数的纵向变化和WOMAC(安大略省西部和麦克马斯特)和 2年和4年的KOOS(膝关节损伤和骨关节炎结果评分)指数。 (3)评估(I)T2参数(平均值、空间分布和层流)的纵向变化 组织)和(Ii)软骨和半月板损伤进展与疼痛和功能变化的关系 在2年和4年的时间里，评估(WOMAC，Koos)、体力活动(PASE)和体能表现。 磁共振成像研究将在以下时间进行半定量(蠕虫)和定量(T2弛豫时间)分析 基线，两年和四年后。所有这些个人的临床信息都将可用(WOMAC分数， Koos，Pase)以及膝关节功能测试(例如，400米步行、屈膝、伸展力量通过 等轴测强度测试)。 我们坚信，我们通过这种方式获得的知识进步 研究将有助于我们更好地了解T2值在骨性关节炎的演变和病理生理学中的作用。 将我们在发病率和正常队列中的发现进行比较，可能会为危险因素如何影响提供证据。 膝关节健康。本研究还可能为如何预防早期骨性关节炎的发生和发展提供证据。 减少与骨性关节炎相关的残疾和疼痛带来的破坏性经济成本。

Based on the NIAMS-sponsored OAI this study will provide unique information on the role of the MR based T2 relaxation time cartilage biomarker in predicting and monitoring knee osteoarthritis in individuals with risk factors for OA and early OA in relation to healthy controls. The specific aims are: (1) To study the prevalence and grade of cartilage and meniscal lesions using the semi-quantitative whole organ magnetic resonance imaging score (WORMS) in normal individuals (n=100), individuals from the incidence (risk factors) (n=300) and progression (early OA) (n=300) cohorts of the OAI aged 45-70 years, and to analyze the relationship of these scores with T2 parameters (mean, spatial distribution and laminar organization) and assess interrelationships between the 3 groups. (2) To determine if baseline T2 parameters (mean, spatial distribution and laminar organization) will predict longitudinal change in WORMS scores and increase in WOMAC (Western Ontario and McMasters) and KOOS (Knee Injury and Osteoarthritis Outcome Score) indices over a period of 2 and 4 years. (3) To assess the longitudinal change in (i) T2 parameters (mean, spatial distribution and laminar organization) and (ii) cartilage and meniscal lesion progression in relation to changes of pain and function scales (WOMAC, KOOS), physical activity (PASE) and physical performance over a period of 2 and 4 years. MR imaging studies will be analyzed semi-quantitatively (WORMS) and quantitatively (T2 relaxation time) at baseline, after 2 and 4 years. Clinical information will be available in all these individuals (WOMAC scores, KOOS, PASE) as well as knee function tests (e.g. 400-meter walk, flexion, extension strength through isometric strength testing). We strongly believe, that the advances in knowledge that we gain through this study will help us better understand the role of T2 values in relation to evolution and pathophysiology of OA. Comparing our findings in the incidence and normal cohorts, it may provide evidence how risk factors impact knee joint health. This study may also provide evidence on how to prevent development of early OA and reduce the devastating economic cost induced by disability and pain associated with OA.