Los Angeles Stroke Prevention/Intervention Research Program in Health Disparities

描述(申请人提供)：洛杉矶中风预防/干预健康差距研究计划是由加州大学洛杉矶分校、洛杉矶县安全网系统中的四个医疗中心、健康的非裔美国家庭以及来自多个社区组织的代表组成的合作伙伴关系，这些组织服务于跨越洛杉矶盆地的低收入少数族裔社区。在这个美国种族/民族最多元化的县，我们提出了一个多学科、高度协作的计划，以创建和测试可持续的干预措施，以减少或消除中风发生中的种族和民族差异，并产生关于这种差异的机制的新知识。项目I创建了一个强大的以社区为基础的组成部分，与社区卫生工作者和移动卫生技术一起创建了一个全面的慢性护理模式干预，将在洛杉矶县安全网中看到的500名最近中风患者中进行相对于常规护理的测试。成本分析和形成性评估将指导财务可持续性计划的制定。项目II将阐明 新的生物学和社会风险因素在中风风险和随时间变化趋势中的作用，在国家数据集中。项目III建立在与洛杉矶市老年局现有密切合作伙伴关系的基础上，开发和测试一种文化定制的行为中风风险因素减少/步行干预-由高级中心工作人员提供-包括来自韩国、中国、非裔美国人和西班牙裔种族/民族的240名高危老年人。四个核心包括支持所有三个项目的行政核心A；研究教育和培训核心B，将为学术研究人员、社区研究支助人员和其他社区利益相关者招聘、保留和开发与中风差异相关的课程；生物标记物收集和分析核心C，以支持项目I和项目III的生物标记数据收集、为所有三个项目提供咨询，并制定关于生物标记物的教育规划；以及社区参与、外联和传播核心D，通过双向知识共享促进和维持社区与学术的伙伴关系，并通过向当地和全国受影响的社区推广中风预防差异研究方面的知识进展，来支持并与所有三个项目互动。

DESCRIPTION (provided by applicant): The Los Angeles Stroke Prevention/ Intervention Research Program in Health Disparities is a partnership of UCLA, four medical centers in the Los Angeles County safety net system, Healthy African American Families, and representatives from multiple community organizations serving low-income minority communities that span the Los Angeles basin. In this most diverse county in the US in race/ethnicity, we propose a multi-disciplinary, highly collaborative Program to create and test sustainable interventions to reduce or eliminate racial and ethnic disparities in the occurrence of stroke, and to generate new knowledge about mechanisms for such disparities. Project I creates a strong community-based component with community health workers and mobile health technology to create a full-fledged Chronic Care Model intervention that will be tested relative to usual care in 500 patients with a recent stroke seen in the Los Angeles County safety net. A cost analysis and a formative evaluation will guide development of a financial sustainability plan. Project II will elucidate the role of novel biological and social risk factors for stroke risk and trends over time, in a nationa data set. Project III builds on an existing close partnership with the City of Los Angeles Department of Aging to develop and test a culturally-tailored behavioral stroke risk factor reduction/walking intervention - delivered by senior center staff-with 240 high risk seniors from Korean, Chinese, African-American and Hispanic racial/ethnic groups. Four cores include an Administrative Core A that supports all three projects; a Research Education and Training Core B that will recruit, retain, and develop stroke disparities-relevant curriculum for academic researchers, community research support personnel and other community stake holders; a Biomarker Collection and Analysis Core C to support Project I and III biomarker data collection, consulting for all three projects, and development of educational programming on biomarkers; and a Community Engagement, Outreach, and Dissemination Core D that supports and interacts with all three projects by promoting and sustaining community-academic partnerships through bidirectional knowledge sharing and by creating strategies for disseminating advances in knowledge about stroke prevention disparities research through outreach to affected communities locally and nationally.