Training Program in Immunology and Inflammation

免疫学和炎症培训计划

基本信息

  • 批准号:
    8495260
  • 负责人:
  • 金额:
    $ 19.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-07-01 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The Immunology and Inflammation training program at NYU School of Medicine will fill an important gap in pre-doctoral and post-doctoral training at the interface between basic immunology and human disease. The intent of the Immunology and Inflammation training program at NYU SoM is to provide training in this rapidly evolving research field. Specifically, the Immunology and Inflammation program aims to train students and postdoctoral fellows in the field of basic immunology research, particularly mechanisms and pathways of host anti-microbial protection that, when activated in an inappropriate manner via either genetic or environmental perturbations, result in inflammatory diseases. A long-term goal of the program is to train a new cadre of researchers in the broad and interdisciplinary area of basic immunology and its relation to inflammatory processes. This knowledge may result in a better understanding of the causes of inflammatory disorders and in the discovery and development of new therapeutic approaches. The training program will have 28 faculty who are highly productive scientists with extensive mentoring experience (they have mentored a total of 282 trainees in the last ten years (103 pre-doctoral and 179 postdoctoral)). The faculty mentors all share a common interest in understanding basic immunological mechanisms and how the distortion and dysregulation of these mechanisms by genetic and environmental factors, such as the microbiome, leads to disease such as metabolic diseases, atherosclerosis, neurodegenerative diseases and chronic infection. We propose a program with 4 pre-doctoral positions and 4 post-doctoral positions focused on training scientists in the study of immunology and inflammation that will complement the 15 existing training programs at NYUSoM. The Immunology and Inflammation program will provide intellectually demanding pre- and postdoctoral training in a highly interactive scientific environment providing rigorous courses, tutorials, and seminars in a broad training environment that encourages diversity. Multi-tiered mentoring plans will allow monitoring of research progress. Trainees will also acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentatin skills. Training of students will include rigorous courses in Immunology, Genetics, Microbiology, Molecular Oncology, Stem Cells and Parasitology. All trainees will participate in the immunology seminar series, an annual retreat, journal clubs and discussion groups as well as lectures focusing on ethical conduct in science and career options. Funds are requested to support 4 pre-doctoral and 4 post-doctoral trainees. These trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat inflammatory diseases.
描述(由申请人提供):纽约大学医学院的免疫学和炎症培训计划将填补基础免疫学和人类疾病之间接口的博士前和博士后培训的重要空白。在纽约大学SoM的免疫学和炎症培训计划的目的是在这个快速发展的研究领域提供培训。具体而言,免疫学和炎症计划旨在培养基础免疫学研究领域的学生和博士后研究员,特别是宿主抗微生物保护的机制和途径,当通过遗传或环境扰动以不适当的方式激活时,导致炎症性疾病。该计划的长期目标是在基础免疫学及其与炎症过程的关系的广泛和跨学科领域培养一批新的研究人员。这些知识可能会导致更好地了解炎症性疾病的原因,并发现和开发新的治疗方法。该培训计划将有28名教师谁是具有丰富的指导经验的高生产力的科学家(他们在过去十年中指导了282名学员(103名博士前和179名博士后))。教师导师都有共同的兴趣,了解基本的免疫机制,以及遗传和环境因素(如微生物组)对这些机制的扭曲和失调如何导致代谢疾病,动脉粥样硬化,神经退行性疾病和慢性感染等疾病。我们提出了一个有4个博士前职位和4个博士后职位的计划,重点是培训免疫学和炎症研究的科学家,这将补充NYUSoM现有的15个培训项目。免疫学和炎症计划将在高度互动的科学环境中提供智力要求高的博士前和博士后培训,在鼓励多样性的广泛培训环境中提供严格的课程,教程和研讨会。多层次的指导计划将允许监测研究进展。学员还将获得批判性地评估科学数据和文献的能力,并将发展他们的写作和演讲技巧。学生的培训将包括免疫学,遗传学,微生物学,分子肿瘤学,干细胞和寄生虫学的严格课程。所有学员将参加免疫学研讨会系列,年度务虚会,期刊俱乐部和讨论小组,以及讲座,重点是在科学和职业选择的道德行为。申请资助4名博士前和4名博士后学员。这些学员将代表新一代的科学家,他们可以为开发治疗炎症性疾病的新疗法做出贡献。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Joel D. Ernst其他文献

The immunological life cycle of tuberculosis
结核病的免疫生命周期
  • DOI:
    10.1038/nri3259
  • 发表时间:
    2012-07-13
  • 期刊:
  • 影响因子:
    60.900
  • 作者:
    Joel D. Ernst
  • 通讯作者:
    Joel D. Ernst
Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome.
吞噬颗粒向墨西哥利什曼原虫寄生液泡的转移是吞噬体获得膜联蛋白 I 之前的短暂现象。
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Helen L. Collins;Ulrich E. Schaible;Joel D. Ernst;David G. Russell
  • 通讯作者:
    David G. Russell
Editorial response: variation in clinical and immune responses to bacille Calmette-Guérin--implications for an improved tuberculosis vaccine.
编辑回应:卡介苗临床和免疫反应的变化——对改进结核病疫苗的影响。
Antibody-Fab and -Fc features promote emMycobacterium tuberculosis/em restriction
抗体的 Fab 和 Fc 特征促进了对结核分枝杆菌的限制。
  • DOI:
    10.1016/j.immuni.2025.05.004
  • 发表时间:
    2025-06-10
  • 期刊:
  • 影响因子:
    26.300
  • 作者:
    Patricia S. Grace;Joshua M. Peters;Jaimie Sixsmith;Richard Lu;Edward B. Irvine;Corinne Luedeman;Brooke A. Fenderson;Andrew Vickers;Matthew D. Slein;Tanya McKitrick;Mo-Hui Wei;Richard D. Cummings;Aaron Wallace;Lisa A. Cavacini;Alok Choudhary;Megan K. Proulx;Christopher Sundling;Gunilla Källenius;Rajko Reljic;Joel D. Ernst;Galit Alter
  • 通讯作者:
    Galit Alter
Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design
寻找并填补 T 细胞介导的结核病免疫机制中的知识空白,为疫苗设计提供信息
  • DOI:
    10.1038/s41577-025-01192-z
  • 发表时间:
    2025-06-13
  • 期刊:
  • 影响因子:
    60.900
  • 作者:
    Emma Lefrançais;Denis Hudrisier;Olivier Neyrolles;Samuel M. Behar;Joel D. Ernst
  • 通讯作者:
    Joel D. Ernst

Joel D. Ernst的其他文献

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{{ truncateString('Joel D. Ernst', 18)}}的其他基金

Functionally distinct human CD4 T cell responses to novel evolutionarily selected M. tuberculosis antigens
功能独特的人类 CD4 T 细胞对新型进化选择的结核分枝杆菌抗原的反应
  • 批准号:
    10735075
  • 财政年份:
    2023
  • 资助金额:
    $ 19.63万
  • 项目类别:
Functional dynamics of TB granuloma architecture
结核肉芽肿结构的功能动力学
  • 批准号:
    10593978
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Functional dynamics of TB granuloma architecture
结核肉芽肿结构的功能动力学
  • 批准号:
    10358264
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Live Imaging of Immunity to M. tuberculosis
结核分枝杆菌免疫实时成像
  • 批准号:
    10326395
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Host genetic diversity, mononuclear phagocytes, and outcomes of TB
宿主遗传多样性、单核吞噬细胞和结核病的结果
  • 批准号:
    10005738
  • 财政年份:
    2020
  • 资助金额:
    $ 19.63万
  • 项目类别:
Host genetic diversity, mononuclear phagocytes, and outcomes of TB
宿主遗传多样性、单核吞噬细胞和结核病的结果
  • 批准号:
    10194362
  • 财政年份:
    2020
  • 资助金额:
    $ 19.63万
  • 项目类别:
Antigen export in M. tuberculosis evasion of CD4 T cells
结核分枝杆菌逃避 CD4 T 细胞的抗原输出
  • 批准号:
    9318402
  • 财政年份:
    2016
  • 资助金额:
    $ 19.63万
  • 项目类别:
Epitope-specific T cell activation to complement TB immunity and vaccine efficacy
表位特异性 T 细胞激活可补充结核病免疫和疫苗功效
  • 批准号:
    8867688
  • 财政年份:
    2014
  • 资助金额:
    $ 19.63万
  • 项目类别:
Initiation of the Immune Response to M. tuberculosis
对结核分枝杆菌的免疫反应的启动
  • 批准号:
    8678398
  • 财政年份:
    2014
  • 资助金额:
    $ 19.63万
  • 项目类别:
Mycobacterium tuberculosis evasion of CD4+ T cells in vivo
体内结核分枝杆菌逃避 CD4 T 细胞
  • 批准号:
    8678383
  • 财政年份:
    2013
  • 资助金额:
    $ 19.63万
  • 项目类别:

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